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View article: Axonemal dynein contributions to flagellar beat types and waveforms
Axonemal dynein contributions to flagellar beat types and waveforms Open
Eukaryotic flagella, or motile cilia, are iconic molecular machines whose beating drives cell propulsion and fluid transport across diverse organisms. Beat type and waveform are tailored to function, differing between species and cell type…
View article: Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency
Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency Open
The 9 + 2 microtubule-based axoneme within motile flagella is well known for its symmetry. However, examples of asymmetric structures and proteins asymmetrically positioned within the 9 + 2 axoneme architecture have been identified. These …
View article: Intraflagellar Transport Selectivity Occurs with the Proximal Portion of the Trypanosome Flagellum
Intraflagellar Transport Selectivity Occurs with the Proximal Portion of the Trypanosome Flagellum Open
Intraflagellar transport (IFT) trains move bidirectionally along the doublet microtubules (DMTs) of the axoneme within the flagellum. In Trypanosoma brucei , IFT trains predominantly associate with four of the nine DMTs. Using high-resolut…
View article: Intraflagellar transport speed is sensitive to genetic and mechanical perturbations to flagellar beating
Intraflagellar transport speed is sensitive to genetic and mechanical perturbations to flagellar beating Open
Two sets of motor proteins underpin motile cilia/flagella function. The axoneme-associated inner and outer dynein arms drive sliding of adjacent axoneme microtubule doublets to periodically bend the flagellum for beating, while intraflagel…
View article: Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency
Proteins with proximal-distal asymmetries in axoneme localisation control flagellum beat frequency Open
The 9+2 microtubule-based axoneme within motile flagella is well known for its symmetry. However, examples of asymmetric structures and proteins asymmetrically positioned within the 9+2 axoneme architecture have been identified in multiple…
View article: Radial spoke protein 9 is necessary for axoneme assembly in <i>Plasmodium</i> but not in trypanosomatid parasites
Radial spoke protein 9 is necessary for axoneme assembly in <i>Plasmodium</i> but not in trypanosomatid parasites Open
Flagella are important for eukaryote cell motility, including in sperm, and are vital for life cycle progression of many unicellular eukaryotic pathogens. The ‘9+2’ axoneme in most motile flagella comprises nine outer doublet and two centr…
View article: Concentration of intraflagellar transport proteins at the ciliary base is required for proper train injection
Concentration of intraflagellar transport proteins at the ciliary base is required for proper train injection Open
Construction of cilia and flagella relies on Intraflagellar Transport (IFT). Although IFT proteins can be found in multiple locations in the cell, transport has only been reported along the axoneme. Here, we reveal that IFT concentration a…
View article: Ca2+ elevations disrupt interactions between intraflagellar transport and the flagella membrane in <i>Chlamydomonas</i>
Ca2+ elevations disrupt interactions between intraflagellar transport and the flagella membrane in <i>Chlamydomonas</i> Open
The movement of ciliary membrane proteins is directed by transient interactions with intraflagellar transport (IFT) trains. The green alga Chlamydomonas has adapted this process for gliding motility, using retrograde IFT motors to move adh…
View article: Flagella Ca<sup>2+</sup>elevations regulate pausing of retrograde intraflagellar transport trains in adherent<i>Chlamydomonas</i>flagella
Flagella Ca<sup>2+</sup>elevations regulate pausing of retrograde intraflagellar transport trains in adherent<i>Chlamydomonas</i>flagella Open
The movement of ciliary membrane proteins is directed by transient interactions with intraflagellar transport (IFT) trains. The green alga Chlamydomonas has adapted this process for gliding motility, using IFT to move adhesive glycoprotein…
View article: Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum
Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum Open
Intraflagellar transport (IFT) is the rapid bidirectional movement of large protein complexes driven by kinesin and dynein motors along microtubule doublets of cilia and flagella. In this study, we used a combination of high-resolution ele…
View article: Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum
Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum Open
Summary Intraflagellar transport (IFT) is the rapid bidirectional movement of large protein complexes driven by kinesin and dynein motors along microtubule doublets of cilia and flagella. Here we used a combination of high-resolution elect…
View article: Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length
Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length Open
Intraflagellar transport (IFT) is required for construction of most cilia and flagella. Here, we used electron microscopy, immunofluorescence and live video microscopy to show that IFT is absent or arrested in the mature flagellum of Trypa…