Cécile Gautier
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View article: Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in<i>Candida albicans</i>
Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in<i>Candida albicans</i> Open
Azole antifungals are widely used to treat Candida infections, yet therapeutic failures are common. In addition to resistance, fungal populations can exhibit tolerance and heteroresistance, subpopulation-driven drug responses that can cont…
View article: Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans
Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans Open
Antimicrobial drug resistance poses a global health threat, requiring a deeper understanding of the evolutionary processes that lead to its emergence in pathogens. Complex evolutionary dynamics involve multiple mutations that can result in…
View article: Epidemiology and prognostic factors of mucormycosis in France (2012–2022): a cross-sectional study nested in a prospective surveillance programme
Epidemiology and prognostic factors of mucormycosis in France (2012–2022): a cross-sectional study nested in a prospective surveillance programme Open
Recurrent financial support from Santé Publique France and Institut Pasteur.
View article: Approaches for identifying and measuring heteroresistance in azole-susceptible <i>Candida</i> isolates
Approaches for identifying and measuring heteroresistance in azole-susceptible <i>Candida</i> isolates Open
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this ph…
View article: Step-wise evolution of azole resistance through copy number variation followed by<i>KSR1</i>loss of heterozygosity in<i>Candida albicans</i>
Step-wise evolution of azole resistance through copy number variation followed by<i>KSR1</i>loss of heterozygosity in<i>Candida albicans</i> Open
Antimicrobial drug resistance poses a global health threat, requiring a deeper understanding of the evolutionary processes that lead to its emergence in pathogens. Complex evolutionary dynamics involve multiple mutations that can result in…
View article: Small molecules restore azole activity against drug-tolerant and drug-resistant <i>Candida</i> isolates
Small molecules restore azole activity against drug-tolerant and drug-resistant <i>Candida</i> isolates Open
Each year, fungi cause more than 1.5 billion infections worldwide and have a devastating impact on human health, particularly in immunocompromised individuals or patients in intensive care units. The limited antifungal arsenal and emerging…
View article: Small Molecules Restore Azole Activity Against Drug-Tolerant and Drug-Resistant<i>Candida</i>Isolates
Small Molecules Restore Azole Activity Against Drug-Tolerant and Drug-Resistant<i>Candida</i>Isolates Open
Each year, fungi cause more than 1.5 billion infections worldwide and have a devastating impact on human health, particularly in immunocompromised individuals or patients in intensive care units. The limited antifungal arsenal and emerging…
View article: Emerging mould infections: Get prepared to meet unexpected fungi in your patient
Emerging mould infections: Get prepared to meet unexpected fungi in your patient Open
Invasive fungal diseases are increasing issues in modern medicine, where the human immunodeficiency virus (HIV) pandemic and the wider use of immunosuppressive drugs generate an ever-growing number of immunocompromised patients with an inc…