Cécile L. Bandet
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View article: CERT-Dependent Ceramide Transport, A Crucial Process in Cells
CERT-Dependent Ceramide Transport, A Crucial Process in Cells Open
In mammalian cells, ceramides are central lipids in sphingolipid metabolism and serve both as signaling lipids and as precursors for other bioactive sphingolipids, ranging from complex glycosphingolipids to “simpler” lipids such as ceramid…
View article: Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes
Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes Open
Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads to the dysregulation of glucose homeostasis, which culmi…
View article: Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells
Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells Open
Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose users in response to insulin and are considered as …
View article: Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions
Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions Open
One main mechanism of insulin resistance (IR), a key feature of type 2 diabetes, is the accumulation of saturated fatty acids (FAs) in the muscles of obese patients with type 2 diabetes. Understanding the mechanism that underlies lipid-ind…