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View article: The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12
The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF-12 Open
Prevention therapy against Dirofilaria immitis in companion animals is currently threatened by the emergence of isolates resistant to macrocyclic lactone anthelmintics. Understanding the control over developmental processes in D. immitis i…
View article: The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes
The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes Open
Resistance to the anthelmintic macrocyclic lactone ivermectin (IVM) has a great impact on the control of parasitic nematodes. The mechanisms by which nematodes adapt to IVM remain to be deciphered. We have identified NHR-8, a nuclear hormo…
View article: Acquired Tolerance to Ivermectin and Moxidectin after Drug Selection Pressure in the Nematode Caenorhabditis elegans
Acquired Tolerance to Ivermectin and Moxidectin after Drug Selection Pressure in the Nematode Caenorhabditis elegans Open
Ivermectin and moxidectin are the most widely administered anthelmintic macrocyclic lactones (MLs) to treat human and animal nematode infections. Their widespread and frequent use has led to a high level of resistance to these drugs. Altho…