Cecilia Karlström
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View article: Thrombotic thrombocytopenic purpura as a complication of pembrolizumab: a case report and literature review
Thrombotic thrombocytopenic purpura as a complication of pembrolizumab: a case report and literature review Open
The success of immune checkpoint inhibitors (ICIs) has revolutionized oncology, with an increasing number of patients receiving treatment every year. However, this progress has been accompanied by a rise in immune-related adverse events (i…
View article: Iatrogenic hemorrhage and extensive venous thromboembolism during iTTP treatment with caplacizumab—A case report
Iatrogenic hemorrhage and extensive venous thromboembolism during iTTP treatment with caplacizumab—A case report Open
Caplacizumab reduces the need for therapeutic plasma exchange (TPE) during treatment for thrombotic thrombocytopenic purpura (TTP), associates with fewer required TPE, and shortens hospital stay. It is therefore recommended as part of stan…
View article: No indication of aberrant neutrophil extracellular trap release in indolent or advanced systemic mastocytosis
No indication of aberrant neutrophil extracellular trap release in indolent or advanced systemic mastocytosis Open
In disease states with chronic inflammation, there is a crosstalk between mast cells and neutrophil granulocytes in the inflamed microenvironment, which may be potentiated by tryptase. In systemic mastocytosis (SM), mast cells are constitu…
View article: Platelet transfusion improves clot formation and platelet function in severely thrombocytopenic haematology patients
Platelet transfusion improves clot formation and platelet function in severely thrombocytopenic haematology patients Open
Summary Prophylactic platelet (PLT) transfusion is a common practice in severely thrombocytopenic patients that reduces mortality, but responses to platelet transfusions are variable and difficult to predict in individual patients. In this…
View article: Platelet transfusions in hematological disorders
Platelet transfusions in hematological disorders Open
Platelets are important for clot formation and vascular integrity. Thrombocytopenic patients with hematological disorders are at risk of bleeding and platelet transfusions are important in supportive care and treatment of lite-threatening …