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View article: The ESCAPER study—exploring protective mechanisms against cardiovascular disease in subjects at high risk: rationale, study protocol, and first results
The ESCAPER study—exploring protective mechanisms against cardiovascular disease in subjects at high risk: rationale, study protocol, and first results Open
Introduction. The ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. Th…
View article: Arterial Stiffness and Markers of Atrial Myopathy
Arterial Stiffness and Markers of Atrial Myopathy Open
Background Arterial stiffness, measured using carotid‐femoral pulse wave velocity (c‐f PWV) and heart rate‐corrected augmentation index (Aix75), is associated with cardiovascular disease, and in some studies incident atrial fibrillation (A…
View article: Impact of a short-term Mediterranean diet intervention on plasma metabolites: a pilot study
Impact of a short-term Mediterranean diet intervention on plasma metabolites: a pilot study Open
View article: The impact of prediabetes and diabetes on endothelial function in a large population-based cohort
The impact of prediabetes and diabetes on endothelial function in a large population-based cohort Open
In a population free from CVD, vascular endothelial dysfunction was primarily associated with manifest diabetes, but not with prediabetes, implying that finger ED may develop when diabetes is established, rather than being an early sign of…
View article: Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination
Defined shapes of carotid artery calcifications on panoramic radiographs correlate with specific signs of cardiovascular disease on ultrasound examination Open
View article: Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture
Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture Open
Our findings show plaque site-specific transcriptional signatures associated with proximal rupture-prone regions of carotid atherosclerotic plaques. This led to the geographical mapping of novel therapeutic targets, such as matrix metallop…
View article: Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis
Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis Open
View article: The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population‐based study
The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population‐based study Open
Aim The metabolite 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definit…
View article: Common carotid artery characteristics in patients with repaired aortic coarctation compared to other cardiovascular risk factors
Common carotid artery characteristics in patients with repaired aortic coarctation compared to other cardiovascular risk factors Open
The mechanism of cIMT thickening in patients with repaired CoA may differ from CAD. While there is concentric remodeling in the latter, we see predominant eccentric remodeling in the CoA group, which could be due to increased flow as a res…
View article: Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases
Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases Open
We aim to investigate if serum levels of microRNAs: miR-126, mir-197 and mir-223, previously implicated in cardiometabolic disease, are reproducibly associated with incident-diabetes (inc-DM), incident-cardiovascular disease (inc-CVD) and …
View article: Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease
Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease Open
Background Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is…
View article: The Malmö Offspring Study (MOS): design, methods and first results
The Malmö Offspring Study (MOS): design, methods and first results Open
As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, …
View article: Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study
Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study Open
OBJECTIVE Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mecha…
View article: Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms
Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms Open
Background: Echolucent carotid plaques have been related to an increased risk of ischemic cerebrovascular events. The aim of the present study was to evaluate whether a new objective ultrasonographic parameter, the statistica…
View article: Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort
Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort Open
Alpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.
View article: Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross‐sectional study
Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross‐sectional study Open
Background There is a need to develop and validate surrogate markers of cardiovascular disease ( CVD ) in subjects with diabetes. The macrovascular changes associated with diabetes include aggravated atherosclerosis, increased arterial sti…