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View article: 702 Comparative genome wide association studies (GWASs) of systemic lupus erythematosus (SLE) and multiple sclerosis (MS) from the million veteran program (MVP)
702 Comparative genome wide association studies (GWASs) of systemic lupus erythematosus (SLE) and multiple sclerosis (MS) from the million veteran program (MVP) Open
Background Strong evidence supports Epstein-Barr virus (EBV) being an original cause for most cases of both systemic lupus erythematosus (SLE) and multiple sclerosis (MS). The Million Veteran Program (MVP) data reduces artifacts from techn…
View article: 701 A million veteran program (MVP) genome-wide association study (GWAS) of systemic and cutaneous lupus erythematosus (SLE & CLE)
701 A million veteran program (MVP) genome-wide association study (GWAS) of systemic and cutaneous lupus erythematosus (SLE & CLE) Open
Background >36,000 Veterans have been diagnosed with systemic lupus erythematosus (SLE). With the SLE and cutaneous lupus (CLE) cases and unaffected controls in MVP, we performed a genome-wide association study (GWAS). Methods Cases with t…
View article: 1401 A Genome Wide Association Scan of SLE genetic risk in a cohort of African-American persons
1401 A Genome Wide Association Scan of SLE genetic risk in a cohort of African-American persons Open
Systemic lupus erythematosus (SLE) is the prototypical multi-system autoimmune disease with diverse clinical features in persons with disease. SLE is also unified by characteristic autoimmunity directed against nucleic acid or nucleoprote…
View article: Genome-wide association study for systemic lupus erythematosus in an egyptian population
Genome-wide association study for systemic lupus erythematosus in an egyptian population Open
Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European an…
View article: Lupus Susceptibility Region Containing <i>CDKN1B</i> rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis
Lupus Susceptibility Region Containing <i>CDKN1B</i> rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis Open
Objective In a recent genome‐wide association study, a significant genetic association between rs34330 of CDKN1B and risk of systemic lupus erythematosus (SLE) in Han Chinese was identified. This study was undertaken to validate the report…
View article: ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico
ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico Open
Our data displayed that ITGAM is a risk factor to SLE in individuals of Mexican population. Concurrently, a risk haplotype in ITGAM confers protection against RA.
View article: Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility
Mechanistic Characterization of RASGRP1 Variants Identifies an hnRNP-K-Regulated Transcriptional Enhancer Contributing to SLE Susceptibility Open
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near RASGRP1, which governs the ERK/MAPK kinase cascade and B-/T-cell differentiation and …
View article: Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians
Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians Open
Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization of HLA effects is extremely challenging. As a result, the contribution of specific HLA allele…
View article: Mechanistic characterization of <i>RASGRP1</i> variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibility
Mechanistic characterization of <i>RASGRP1</i> variants identifies an hnRNP K-regulated transcriptional enhancer contributing to SLE susceptibility Open
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near RASGRP1 , which governs the ERK/MAPK kinase cascade and B-/T-cell differentiation and…
View article: 3 Confirmation of 5 novel susceptibility loci for systemic lupus erythematosus (sle) and integrated network analysis of 82 sle susceptibility loci
3 Confirmation of 5 novel susceptibility loci for systemic lupus erythematosus (sle) and integrated network analysis of 82 sle susceptibility loci Open
Background and aims We recently identified ten novel SLE susceptibility loci in Asian populations and uncovered several additional suggestive loci requiring further validation. This study aimed to replicate five of these suggestive loci fo…
View article: Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations
Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations Open
Ten novel loci have been found to be associated with systemic lupus erythematosus (SLE) susceptibility by a recent genome-wide association study conducted in Europeans. To test their disease associations and genetic similarities/difference…
View article: Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci
Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci Open
We recently identified ten novel SLE susceptibility loci in Asians and uncovered several additional suggestive loci requiring further validation. This study aimed to replicate five of these suggestive loci in a Han Chinese cohort from Hong…
View article: Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy
Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy Open
Known susceptibility loci together can only explain about 6–8% of the disease heritability of IgA nephropathy (IgAN), suggesting that there are still a large number of genetic variants remained to be discovered. We previously identified Ig…