Explanipedia

Enhancing RNA-Based Technologies Using Enzyme-Derived Lipoamino Acids Open

Salomé Azevedo, Célia Faustino, Maria H.L. Ribeiro · 2024

This work aims to contribute to nucleic acid therapy advances by highlighting RNA interactions with novel compounds, namely lipoaminoacids (LAAs), which show great potential as non-viral vectors. LAAs not only retain the advantages associa…

Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials Open

A.S. Serras, Célia Faustino, Lídia Pinheiro · 2024

Cancer is still ranked among the top three causes of death in the 30- to 69-year-old age group in most countries and carries considerable societal and macroeconomic costs that differ depending on the cancer type, geography, and patient gen…

Triterpenes Drug Delivery Systems, a Modern Approach for Arthritis Targeted Therapy Open

Célia Faustino, Noélia Duarte, Lídia Pinheiro · 2023

Arthritis is a major cause of disability. Currently available anti-arthritic drugs, such as disease-modifying anti-rheumatic drugs (DMARDs), have serious side-effects associated with long-term use. Triterpenoids are natural products with k…

Exploring Functionalized Magnetic Hydrogel Polyvinyl Alcohol and Chitosan Electrospun Nanofibers Open

Mónica Guerra, Fábio F. F. Garrudo, Célia Faustino, M. Emília Rosa, Maria H.L. Ribeiro · 2023

Nanofibrous materials present interesting characteristics, such as higher area/mass ratio and reactivity. These properties have been exploited in different applications, such as drug-controlled release and site-specific targeting of biomol…

Triterpenes as Potential Drug Candidates for Rheumatoid Arthritis Treatment Open

Célia Faustino, Lídia Pinheiro, Noélia Duarte · 2023

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint inflammation, swelling and pain. Although RA mainly affects the joints, the disease can also have systemic implications. The presence of autoanti…

Rapid UV-Vis spectroscopy methods for quantification of ranitidine tablets Open

Patrícia Ríjo, Lara Ribeiro, Marisa Nicolai, Paula Pereira, Célia Faustino · 2021

Ranitidine is a histamine H2-receptor antagonist that inhibits gastric acid secretion, commonly used in the treatment and prophylaxis of peptic ulcer and gastroesophageal reflux disease. Over-the-counter ranitidine hydrochloride tablets ar…

Analytical Rheology of Honey: A State-of-the-Art Review Open

Célia Faustino, Lídia Pinheiro · 2021

Honey has been used as a nutraceutical product since ancient times due to its nutritional and medicinal properties. Honey rheology influences its organoleptic properties and is relevant for processing and quality control. This review summa…

Dehydroabietic Acid Microencapsulation Potential as Biofilm-Mediated Infections Treatment Open

Íris Neto, Eva María Domínguez-Martín, Epole Ntungwe, Catarina Pinto Reis, Milica Pešić , et al. · 2021

The antimicrobial activity of dehydroabietic acid (DHA) for its use as an antibiofilm agent was tested in this work. DHA was assayed against a collection of Gram-positive, Gram-negative sensitive and resistant bacteria and yeasts through t…

Design of a New Gemini Lipoaminoacid with Immobilized Lipases Based on an Eco-Friendly Biosynthetic Process Open

Patrícia M. Carvalho, Rita C. Guedes, Maria Rosário Bronze, Célia Faustino, Maria H.L. Ribeiro · 2021

Lipoaminoacids (LAA) are an important group of biosurfactants, formed by a polar hydrophilic part (amino acid) and a hydrophobic tail (lipid). The gemini LAA structures allow the formation of a supramolecular complex with bioactive molecul…

Screening the dermatological potential of Plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase Open

Joana M. Andrade, Eva María Domínguez-Martín, Marisa Nicolai, Célia Faustino, Luís Monteiro Rodrigues , et al. · 2020

A series of Plectranthus spp. plant extracts (aqueous, acetonic, methanolic and ethyl acetic) obtained from eight different species, and previously isolated compounds (ranging from polyphenols, diterpenes and triterpenes), were assa…

Erratum: Ribeiro, M. H. L. et al. Lipoaminoacids Enzyme-Based Production and Application as Gene Delivery Vectors. Catalysts 2019, 9, 977 Open

Maria H.L. Ribeiro, Patrícia M. Carvalho, Sandra Martins, Célia Faustino · 2020

The authors wish to make the following erratum to this paper [...]

Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy Open

Célia Faustino, Lídia Pinheiro · 2020

Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty years, remains the gold standard in the treatment of life-threatening invasive fungal infections and visceral leishmaniasis. Due to its poor water …

Lipoaminoacids Enzyme-Based Production and Application as Gene Delivery Vectors Open

Maria H.L. Ribeiro, Patrícia M. Carvalho, Tiago Damas Martins, Célia Faustino · 2019

Biosurfactant compounds have been studied in many applications, including biomedical, food, cosmetic, agriculture, and bioremediation areas, mainly due to their low toxicity, high biodegradability, and multifunctionality. Among biosurfacta…

Anticancer Hybrid Combinations with phenolic compounds Open

Eva María Domínguez Martín, Ana Marı́a Dı́az-Lanza, Patrícia Ríjo, Célia Faustino · 2019

Different types of treatments are being employed to overcome cancer, which is characterized by abnormal cell growth involving cell division without control. However, their usually lack of selectivity and the development of resistance resul…

Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities Open

Diogo Matias, Marisa Nicolai, Ana S. Fernandes, Nuno Saraiva, Joana Almeida , et al. · 2019

Medicinal plants of the Plectranthus genus (Lamiaceae) are known for their ethnopharmacological relevance, mainly against infectious, dermatologic and gastrointestinal pathologies. Three Plectranthus species originated from South Africa, n…

Cytotoxic Activity of Royleanone Diterpenes from Plectranthus madagascariensis Benth Open

Diogo Matias, Marisa Nicolai, Lucı́lia Saraiva, Rute Pinheiro, Célia Faustino , et al. · 2019

Cytotoxicity screenings have identified Plectranthus plants as potential sources of antitumor lead compounds. In this work, several extracts from Plectranthus madagascariensis were prepared using different solvents (acetone, …

Physicochemical, Antioxidant and Antimicrobial Properties of selected Portuguese Commercial Monofloral Honeys Open

João Gonçalves, Isabel Ribeiro, Joana Marçalo, Patrícia Ríjo, Célia Faustino , et al. · 2018

The physicochemical, antioxidant and antimicrobial properties of selected Portuguese commercial honeys have been characterized aiming at establishing correlations between honey bioactivity and the physicochemical descriptors. All honey sam…

Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity Open

Joana M. Andrade, Célia Faustino, Catarina García, Diogo Ladeiras, Catarina Pinto Reis , et al. · 2018

The worldwide interest in the use of medicinal plants has been growing, and its beneficial effects being rediscovered for the development of new drugs. Based on their vast ethnopharmacological applications, which inspired current research …

Amino Acid-Based Surfactants for Biomedical Applications Open

Lídia Pinheiro, Célia Faustino · 2017

The growing demand for surfactants worldwide has a profound impact on the environment and public health. The quest for environmentally friendly “green” surfactants has driven research toward bio-based surfactants from renewable sources wit…

Célia Faustino YOU? Author Swipe