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View article: Integration of an OS-Based Machine Learning Score (AS Score) and Immunoscore as Ancillary Tools for Predicting Immunotherapy Response in Sarcomas
Integration of an OS-Based Machine Learning Score (AS Score) and Immunoscore as Ancillary Tools for Predicting Immunotherapy Response in Sarcomas Open
Background: Angiosarcomas (ASs) represent a heterogeneous and highly aggressive subset of tumors that respond poorly to systemic treatments and are associated with short progression-free survival (PFS) and overall survival (OS). The aim of…
View article: [Translated article] Avelumab to treat Merkel cell carcinoma: real-life experience in a dedicated oncology center
[Translated article] Avelumab to treat Merkel cell carcinoma: real-life experience in a dedicated oncology center Open
The arrival of immunotherapy has revolutioned the management of patients with metastatic Merkel cell carcinoma (MCC). We conducted an observational, retrospective study of 14 cases treated with avelumab. The response rate was 57%: complete…
View article: Combined Merkel Cell Carcinoma and Squamous Cell Carcinoma: A Systematic Review
Combined Merkel Cell Carcinoma and Squamous Cell Carcinoma: A Systematic Review Open
Combined Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) have classically been regarded as more aggressive than conventional, pure, Merkel cell polyomavirus (MCPyV)-positive MCC. It is still unknown whether combined MCC and S…
View article: Clinical, histological, and molecular differences in melanoma due to different <i>TERT</i> promoter mutations subtypes. A retrospective cross‐sectional study in 684 melanoma patients
Clinical, histological, and molecular differences in melanoma due to different <i>TERT</i> promoter mutations subtypes. A retrospective cross‐sectional study in 684 melanoma patients Open
Differences in survival according to the pTERT mutation subtypes (−124C > T, −146C > T, and tandem −138_139CC > TT) have been observed. The present study aimed to describe the clinical as the histopathological and molecular cutaneous melan…
View article: Molecular Profile of Subungual Melanoma: A MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT Promoter Status
Molecular Profile of Subungual Melanoma: A MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT Promoter Status Open
Background: Subungual melanoma (SM) is an unusual type of melanocytic tumor affecting the nail apparatus. The mutational prevalence of the most prominently mutated genes in melanoma has been reported in small cohorts of SM, with unclear co…
View article: Nodular type but not vitamin D levels increases the risk of second primary cancers in melanoma patients: An observational study of 663 patients
Nodular type but not vitamin D levels increases the risk of second primary cancers in melanoma patients: An observational study of 663 patients Open
Our results suggest that vitamin D deficiency is not associated with an increased risk of developing non-cutaneous SPC in melanoma patients. However, age over 60 years and nodular melanoma subtype increase the risk for non-cutaneous SPC de…
View article: High‐ and intermediate‐risk susceptibility variants in melanoma families from the Mediterranean area: A multicentre cohort from the <scp>MelaNostrum</scp> Consortium
High‐ and intermediate‐risk susceptibility variants in melanoma families from the Mediterranean area: A multicentre cohort from the <span>MelaNostrum</span> Consortium Open
Background Most of large epidemiological studies on melanoma susceptibility have been conducted on fair skinned individuals (US, Australia and Northern Europe), while Southern European populations, characterized by high UV exposure and dar…
View article: Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study
Topographical and Chronological Analysis of Thin Cutaneous Melanoma’s Progressions: A Multicentric Study Open
A great portion of cutaneous melanoma’s diagnoses nowadays is attributed to thin tumors with up to 1 mm in Breslow thickness (hereafter thin CMs), which occasionally metastasize. The objective of this study was to identify thin CM’s metast…
View article: Germline cancer‐related mutations detected by routine targeted NGS for tumour analysis: A series of 357 melanoma patients
Germline cancer‐related mutations detected by routine targeted NGS for tumour analysis: A series of 357 melanoma patients Open
Screening for somatic mutations using next-generation sequencing (NGS) is the standard of care for many cancers to select the most appropriate tratment. Ideally, matched tumour-normal (T/N) sequencing allows the identification of true soma…
View article: [Translated article] Lymphovascular Invasion and High Mitotic Count Are Associated With Increased Risk of Recurrence in Pleomorphic Dermal Sarcoma
[Translated article] Lymphovascular Invasion and High Mitotic Count Are Associated With Increased Risk of Recurrence in Pleomorphic Dermal Sarcoma Open
PDS is an aggressive tumor in which a high mitotic count (≥18) and lymphovascular invasion are associated with a higher risk of recurrence and worse disease-free survival. Necrosis and perineural invasion are also probably linked to increa…
View article: Supplementary Material for: Molecular Profile of Subungual Melanoma: a MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT promoter status.
Supplementary Material for: Molecular Profile of Subungual Melanoma: a MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT promoter status. Open
Background: Subungual melanoma (SM) is an unusual type of melanocytic tumor affecting the nail apparatus. The mutational prevalence of the most prominently mutated genes in melanoma has been reported in small cohorts of SM, with unclear co…
View article: [Translated article] Histologically agressive basal cell carcinoma with particular emphasis on galeal infiltration of the scalp
[Translated article] Histologically agressive basal cell carcinoma with particular emphasis on galeal infiltration of the scalp Open
Familiarity with predictors of more aggressive behavior is crucial to the management of basal cell carcinoma (BCC). Risk factors for aggressive BCC are essentially divided into clinical and histopathologic factors. In this review we examin…
View article: Impact of a personal history of cutaneous squamous cell carcinoma in the overall survival of cutaneous melanoma patients
Impact of a personal history of cutaneous squamous cell carcinoma in the overall survival of cutaneous melanoma patients Open
Background There have been previous studies on the association between cutaneous squamous cell carcinoma (cSCC) and cutaneous melanoma (CM) survival, and also the association between skin cancers and relative telomere length (RTL). In this…
View article: Cemiplimab in Advanced Cutaneous Squamous Cell Carcinoma: Real-World Experience in a Monographic Oncology Center
Cemiplimab in Advanced Cutaneous Squamous Cell Carcinoma: Real-World Experience in a Monographic Oncology Center Open
Management of advanced cSCC is challenging, and many available systemic medications have modest efficacy. Cemiplimab has demonstrated efficacy in the treatment of advanced cSCC in clinical trials, but real-world data are still limited. Wit…
View article: [Translated article] Prognostic Value of Vitamin D Serum Levels in Cutaneous Melanoma
[Translated article] Prognostic Value of Vitamin D Serum Levels in Cutaneous Melanoma Open
Introduction: Vitamin D plays a fundamental role in many metabolic pathways, including those involved in cell proliferation and the immune response. Serum levels of this vitamin have been linked to melanoma risk and prognosis. This study a…
View article: [Translated article] Subungual Melanocytic Lesions in Pediatric Patients
[Translated article] Subungual Melanocytic Lesions in Pediatric Patients Open
The study of subungual melanocytic lesions can present challenges because of the clinical and histologic characteristics of the nail unit and the difficulty of performing nail biopsies and processing specimens. These lesions can be even mo…
View article: Supplementary Material for: Differences by Anatomical Site of Non-Acral Lentiginous Melanomas of the Lower Limb
Supplementary Material for: Differences by Anatomical Site of Non-Acral Lentiginous Melanomas of the Lower Limb Open
Background: Acral location of melanomas is associated with poor survival. It can be due, at least in part, to the fact that acral lentiginous melanoma, a distinct melanoma subtype, has a particular biological profile and a bad clinical beh…
View article: Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study
Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma: A Multicenter Propensity Score Matching Study Open
The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational …
View article: Distribution and clinical role of KIT gene mutations in melanoma according to subtype: a study of 492 Spanish patients
Distribution and clinical role of KIT gene mutations in melanoma according to subtype: a study of 492 Spanish patients Open
Our results suggest that KIT mutations in melanoma tumours are unrelated to the development of nevi or chronic sun damage, but their presence is associated with aggressive melanomas which show ulceration, vascular invasiveness, and increas…
View article: Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development
Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development Open
According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with a propensity to melanocyte proliferation and another one associated with cumulative solar damage (CSD). While characterized clinically and epidem…
View article: Subungual Melanocytic Lesions: Key Clinical and Pathologic Concepts and Biopsy Techniques
Subungual Melanocytic Lesions: Key Clinical and Pathologic Concepts and Biopsy Techniques Open
Both dermatologists and pathologists sometimes find daunting the evaluation of melanonychia (especially subungual melanocytic lesions) because of the fear of performing nail surgery due to the risk of dystrophy, difficulties processing and…
View article: Localized Injection-site Toxic Erythema of Chemotherapy: An Under-recognized Acquaintance Revisited
Localized Injection-site Toxic Erythema of Chemotherapy: An Under-recognized Acquaintance Revisited Open
Conventional chemotherapy agents commonly cause infusion-site lesions, such as chemical cellulitis due to drug extravasation and evanescent eruptions (1-7).One of the most characteristic (although perhaps little-known) local cutaneous adve…
View article: Supplementary Material for: Adherence to Primary Prevention and Skin Self-Examination Practices by Spanish Melanoma Patients
Supplementary Material for: Adherence to Primary Prevention and Skin Self-Examination Practices by Spanish Melanoma Patients Open
Background: The incidence of cutaneous melanoma, an important global public health problem, has been increasing over the last several decades. Objectives: In order to decrease melanoma-related mortality, ways to communicate and implement t…
View article: Protocol for the Histologic Diagnosis of Cutaneous Melanoma: Consensus Statement of the Spanish Society of Pathology and the Spanish Academy of Dermatology and Venereology (AEDV) for the National Cutaneous Melanoma Registry
Protocol for the Histologic Diagnosis of Cutaneous Melanoma: Consensus Statement of the Spanish Society of Pathology and the Spanish Academy of Dermatology and Venereology (AEDV) for the National Cutaneous Melanoma Registry Open
This article describes a proposed protocol for the histologic diagnosis of cutaneous melanoma developed for the National Cutaneous Melanoma Registry managed by the Spanish Academy of Dermatology and Venereology (AEDV). Following a review o…
View article: Prognostic Role of Non-Identification of Sentinel Lymph Node in Cutaneous Melanoma Patients: An Observational Retrospective Study
Prognostic Role of Non-Identification of Sentinel Lymph Node in Cutaneous Melanoma Patients: An Observational Retrospective Study Open
Background: Sentinel lymph node (SLN) status is recognized as the most important prognostic factor for patients with cutaneous melanoma. However, sometimes it is not possible to identify SLN. The phenomenon of non-identification of SLN and…