Explanipedia

Root Architecture and Early Growth of Soybean as Influenced by Nitrogen Fertilizer Placement Open

Célia Gomes, Laura Antônia Lange Obregon Bertolli, Luís Carvalho Lourenço, B.C. do Amaral, Amanda Bernuci , et al. · 2025

Brazil stands out as one of the world’s largest producers and exporters of grains, particularly soybeans. This crop exhibits high nitrogen demand, an essential nutrient for its development. However, soybean possesses the ability to meet pa…

Osteosarcoma cells exploit lung fibroblast-driven inflammatory microenvironment for metastasis formation Open

Gabriela Sampaio-Ribeiro, Sara F.F. Almeida, Hugo R. S. Ferreira, Liliana Santos, Célia Gomes · 2025

Metastatic colonization relies on the dynamic interaction between disseminated tumor cells and stromal cells in distant organs. Here, we investigate how osteosarcoma cells exploit this interplay with resident fibroblasts to establish a sup…

GRPR-targeted gold nanoparticles as selective radiotherapy enhancers in glioblastoma Open

Ana Rita Carvalho Teixeira, Joana Antunes, Catarina I. G. Pinto, Maria Paula Cabral Campello, Pedro M.P. Santos , et al. · 2025

Objective. Glioblastoma multiforme (GBM) is the most diagnosed primary brain tumor in adults and remains associated with a poor prognosis due to its aggressive nature. As tumor recurrence is often observed after standard radiation treatmen…

Co-targeting the CD73-adenosinergic axis enhances the anti-tumor efficacy of anti-PD-L1 immunotherapy in bladder cancer Open

F. Furriel, Hugo R. S. Ferreira, Gabriela Sampaio-Ribeiro, Margarida Pereira, Catarina Eloy , et al. · 2025

Immune checkpoint inhibitors have significantly improved advanced bladder cancer care, but resistance remains a significant challenge. Adenosinergic signaling is an immunosuppressive mechanism hindered by tumor cells to escape from immune …

Is Copper-61 the New Gallium-68? Automation and Preclinical Proof-of-Concept of 61Cu-Based Radiopharmaceuticals for Prostate Cancer Imaging Open

Diana I. Rodrigues, Alexandra Fonseca, S. J. C. do Carmo, José Sereno, Ivanna Hrynchak , et al. · 2025

Background: While gallium-68 has traditionally dominated PET imaging in oncology, copper radionuclides have sparked interest for their potential applications in nuclear medicine and theranostics. Considering the advantageous physical decay…

177Lu-Trastuzumab Radionuclide Therapy: an Effective Approach for Resistant Brain Metastases in HER2+ Breast Cancer Open

Liliana Santos, Ivanna Hrynchak, José Sereno, Hugo R. S. Ferreira, Magda Silva , et al. · 2025

Purpose Breast cancer (BC) is the most common malignancy in women, with HER2 amplification present in 25–30% of metastatic cases. Although HER2-targeted therapies like trastuzumab have significantly improved patient outcomes, their efficac…

Unveiling the potential of copper-61 vs. gallium-68 for SSTR PET imaging Open

Alexandra Fonseca, José Sereno, Sara F.F. Almeida, Hugo R. S. Ferreira, Ivanna Hrynchak , et al. · 2025

Purpose In recent years, copper-61 has attracted considerable attention from both physicists and radiochemists due to its favorable physical decay properties for PET imaging and its ease of production at any cyclotron center producing [ 18…

A switch-on chemo-photothermal nanotherapy impairs glioblastoma Open

Maria Mendes, Maria António, Ana L. Daniel‐da‐Silva, José Sereno, Rui Caetano Oliveira , et al. · 2025

Judiciously combined modality approaches have proved highly effective for treating most forms of cancer, including glioblastoma. Created in BioRender. Mendes, M. (2025) https://BioRender.com/z98a881.

Relato de caso de endocardite por Priestia megaterium Open

Lucas Tadeu Bidinotto, Márcia Guimarães da Silva, M. Pierre, Célia Gomes, Luciana Souza Jorge · 2024

Endocardite é uma infecção grave associada a morbimortalidade importante e pode ser causada por vários microrganismos, mais frequentemente por Enteroccus faecalis, Staphylococcus aureus e Streptococcus sp. O tratamento de pacientes com end…

The potential of exosomes as a new therapeutic strategy for glioblastoma Open

Leonor Cunha Silva, Francisco Branco, Joana Cunha, Carla Vitorino, Célia Gomes , et al. · 2024

Glioblastoma (GBM) stands for the most common and aggressive type of brain tumour in adults. It is highly invasive, which explains its short rate of survival. Little is known about its risk factors, and current therapy is still ineffective…

ENPP1 induces blood–brain barrier dysfunction and promotes brain metastasis formation in human epidermal growth factor receptor 2-positive breast cancer Open

Liliana Santos, Francesca Tomatis, Hugo R. S. Ferreira, Sara F.F. Almeida, Edward Ciputra , et al. · 2024

Background Brain metastasis (BrM) is a devastating end-stage neurological complication that occurs in up to 50% of human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients. Understanding how disseminating tumor…

Brain metastasis: An insight into novel molecular targets for theranostic approaches Open

Liliana Santos, João Nuno Moreira, Antero Abrunhosa, Célia Gomes · 2024

Brain metastases (BrM) are common malignant lesions in the central nervous system, and pose a significant threat in advanced-stage malignancies due to delayed diagnosis and limited therapeutic options. Their distinct genomic profiles under…

Deciphering the impact of cancer cell’s secretome and its derived-peptide VGF on breast cancer brain metastasis Open

Rita Carvalho, Liliana Santos, Inês Conde, Ricardo A. Leitão, Hugo R. S. Ferreira , et al. · 2024

Brain metastases (BM) are one of the most serious clinical problems in breast cancer (BC) progression, associated with lower survival rates and a lack of effective therapies. Thus, to dissect the early stages of the brain metastatic proces…

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling Open

Sara F.F. Almeida, Liliana Santos, Gabriela Sampaio-Ribeiro, Hugo R. S. Ferreira, Nuno Lima , et al. · 2023

Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy Open

Daniela Mateus, Ana Isabel Sebastião, Manuela F. Frasco, Mylène A. Carrascal, Amílcar Falcão , et al. · 2023

The accelerated development of antitumor immunotherapies in recent years has brought immunomodulation into the spotlight. These include immunotherapeutic treatments with dendritic cell (DC)‐based vaccines which can elicit tumor‐specific im…

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling Open

Sara F.F. Almeida, Liliana Santos, Gabriela Ribeiro, Hugo R. S. Ferreira, Nuno Lima , et al. · 2023

Lung metastasis represents the leading cause of osteosarcoma-related death. Progress in preventing lung metastasis is pretty modest due to the inherent complexity of the metastatic process and the lack of suitable models. Herein, we provid…

Self-Renewal and Pluripotency in Osteosarcoma Stem Cells’ Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers Open

Sara R. Martins‐Neves, Gabriela Sampaio-Ribeiro, Célia Gomes · 2023

Osteosarcoma is a highly malignant bone tumor derived from mesenchymal cells that contains self-renewing cancer stem cells (CSCs), which are responsible for tumor progression and chemotherapy resistance. Understanding the signaling pathway…

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3 Open

David Rufino‐Ramos, Patrícia Albuquerque, Kevin Leandro, Vítor Carmona, Inês M. Martins , et al. · 2023

Osteosarcoma‐Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis Open

Sara F.F. Almeida, Alexandra Fonseca, José Sereno, Hugo R. S. Ferreira, Mariana Pais , et al. · 2022

Lung metastases represent the most adverse clinical factor and rank as the leading cause of osteosarcoma‐related death. Nearly 80% of patients present lung micrometastasis at diagnosis not detected with current clinical tools. Herein, an e…

Chemoresistance-Related Stem Cell Signaling in Osteosarcoma and Its Plausible Contribution to Poor Therapeutic Response: A Discussion That Still Matters Open

Sara R. Martins‐Neves, Gabriela Sampaio-Ribeiro, Célia Gomes · 2022

Osteosarcoma is amongst the most prevalent bone sarcomas and majorly afflicts children and adolescents. Therapeutic regimens based on the triad of doxorubicin, cisplatin and methotrexate have been used as the state-of-the-art approach to c…

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans Open

José M. Vicencio, Rachel Evans, R. Green, Zhengwen An, Jinhai Deng , et al. · 2022

Terapia nutricional na unidade de terapia intensiva: avaliação do grau de conhecimento de médicos, enfermeiros e nutricionistas Open

Marina Mendes, Thaiana Matos, Rosimarie Salazar, Célia Gomes, Beatriz Almeida Nina , et al. · 2022

Introdução: A terapia nutricional (TN) é de extrema importância dentro da unidade de terapia intensiva (UTI), visto que é parte fundamental no cuidado do paciente grave, sendo necessário o conhecimento sobre essa temática pelos profissiona…

Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies Open

Ivanna Hrynchak, Liliana Santos, Amílcar Falcão, Célia Gomes, Antero Abrunhosa · 2021

The overexpression of human epidermal growth factor 2 (HER2) in breast cancer (BC) has been associated with a more aggressive tumor subtype, poorer prognosis and shorter overall survival. In this context, the development of HER2-targeted r…

CD39 and CD73 expression on T cells and tumor cells in bladder cancer Open

F. Teixeira Gabriel Furriel, Ángel Onzari Luna Santos, Célia Gomes, B. Parada, Vivian Raquel Bezerra de Sousa , et al. · 2021

Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance Open

Joana B. Loureiro, Liliana Raimundo, Juliana Calheiros, Carla Carvalho, Valentina Barcherini , et al. · 2021

Melanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict pro…

A selective p53 activator and anticancer agent to improve colorectal cancer therapy Open

Helena Ramos, Maria I. L. Soares, Joana Silva, Liliana Raimundo, Juliana Calheiros , et al. · 2021

In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy Open

João Calmeiro, Luís Mendes, Iola F. Duarte, Catarina Leitão, Adriana Ramos Tavares , et al. · 2021

Dendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often fail to generate robust results between trials. Translation to the clinic has been hindered in part by the lack of standard operation procedures for …

In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling Strategies Open

Sara F.F. Almeida, Liliana Santos, Amílcar Falcão, Célia Gomes, Antero Abrunhosa · 2020

Extracellular vesicles (EVs) are naturally secreted vesicles that have attracted a large amount of interest in nanomedicine in recent years due to their innate biocompatibility, high stability, low immunogenicity, and important role in cel…

Targeting p53 with SLMP53-2 for melanoma treatment: counteracting tumour proliferation, dissemination and therapeutic resistance Open

Joana B. Loureiro, Liliana Raimundo, Juliana Calheiros, Valentina Barcherini, Nuno Lima , et al. · 2020

Background and purpose: Melanoma is the deadliest form of skin cancer mostly due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagen…

P04.01 Dendritic-cell based immunotherapy targeting pancreatic and NSCLC cancer stem cells Open

João Calmeiro, Mylène A. Carrascal, Luís Mendes, IF Duarte, Célia Gomes , et al. · 2020

Background The field of cancer immunotherapy is growing at a fast pace, with new developments in this field leading to a change in cancer therapy. Dendritic cells (DCs) are one of the central tools in cellular anti-tumour immunotherapy and…

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