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View article: Untangling bacterial DNA topoisomerases functions
Untangling bacterial DNA topoisomerases functions Open
Topoisomerases are the main enzymes capable of resolving the topological constraints imposed by DNA transactions such as transcription or replication. All bacteria possess topoisomerases of different types. Although bacteria with circular …
View article: DNA topoisomerase I acts as supercoiling sensor for transcription elongation in<i>E. coli</i>
DNA topoisomerase I acts as supercoiling sensor for transcription elongation in<i>E. coli</i> Open
When DNA is transcribed to RNA, the DNA double helix is constantly unwound and rewound to provide access for RNA polymerase (RNAP). This induces DNA supercoiling as a function of transcript length due to over- and under-twisting of the DNA…
View article: Transcription-induced domains form the elementary constraining building blocks of bacterial chromosomes
Transcription-induced domains form the elementary constraining building blocks of bacterial chromosomes Open
Transcription generates local topological and mechanical constraints on the DNA fiber, leading to the generation of supercoiled chromosome domains in bacteria. However, the global impact of transcription on chromosome organization remains …