Céline Bouchard
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View article: Estetrol for the treatment of moderate to severe vasomotor symptoms in postmenopausal women: The design of the E4COMFORT I and II trials
Estetrol for the treatment of moderate to severe vasomotor symptoms in postmenopausal women: The design of the E4COMFORT I and II trials Open
Estetrol is a natural estrogen with a favorable safety profile, showing minimal effects on liver proteins, blood clotting, and breast tissue, which may reduce the risks of blood clots and cardiovascular disease. This review presents the pr…
View article: Treating moderate to severe menopausal vasomotor symptoms with fezolinetant: responder analysis of the phase 3b DAYLIGHT study
Treating moderate to severe menopausal vasomotor symptoms with fezolinetant: responder analysis of the phase 3b DAYLIGHT study Open
Objectives: To characterize the efficacy of fezolinetant for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause using responder analyses of VMS frequency, patient-reported outcomes (PROs) of quality of l…
View article: Effects of estetrol/drospirenone on self-reported physical and emotional premenstrual and menstrual symptoms: Data from the phase 3 clinical trial in the United States and Canada
Effects of estetrol/drospirenone on self-reported physical and emotional premenstrual and menstrual symptoms: Data from the phase 3 clinical trial in the United States and Canada Open
In first time pill users, the estetrol/drospirenone containing oral contraceptive significantly reduces menstrual pain, premenstrual and menstrual water retention and premenstrual negative affect. In those switching from another pill, the …
View article: Prevalence and impact of vasomotor symptoms due to menopause among women in Canada: A subgroup analysis from an international cross-sectional survey of Women with Vasomotor Symptoms Associated with Menopause (WARM Study)
Prevalence and impact of vasomotor symptoms due to menopause among women in Canada: A subgroup analysis from an international cross-sectional survey of Women with Vasomotor Symptoms Associated with Menopause (WARM Study) Open
Objective The aim of the study was to assess the prevalence of postmenopausal vasomotor symptoms (VMS) and the impact of VMS and related treatment patterns among perimenopausal and postmenopausal Canadian women. Methods A subgroup analysis…
View article: Efficacy and safety of fezolinetant for moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy: phase 3b randomised controlled trial
Efficacy and safety of fezolinetant for moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy: phase 3b randomised controlled trial Open
Objectives To assess the efficacy and safety of the non-hormonal, neurokinin 3 receptor antagonist, fezolinetant, to treat moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy. Design P…
View article: Utility of Colonoscopy for the Screening and Management of Cervical Cancer in Africa: A Cross-Sectional Analysis of Providers' Training and Practices
Utility of Colonoscopy for the Screening and Management of Cervical Cancer in Africa: A Cross-Sectional Analysis of Providers' Training and Practices Open
PURPOSE Cervical cancer is a public health issue in Africa with devastating socioeconomic consequences due to the lack of organized screening programs. The success of screening programs depends on the appropriate investigation and manageme…
View article: Effects of E4/DRSP on self-reported physical and emotional premenstrual and menstrual symptoms: data from the phase 3 clinical trial in Europe and Russia
Effects of E4/DRSP on self-reported physical and emotional premenstrual and menstrual symptoms: data from the phase 3 clinical trial in Europe and Russia Open
E4/DRSP starters experienced significant improvements in the domains Pain, Water Retention and Negative Affect particularly benefiting those with more severe baseline symptoms. Switchers showed minimal changes.
View article: Utility of colposcopy for the screening and management of cervical cancer in Africa: a cross-sectional analysis of providers’ training and practices
Utility of colposcopy for the screening and management of cervical cancer in Africa: a cross-sectional analysis of providers’ training and practices Open
Introduction : Cervical cancer is a public health issue in Africa with devastating socioeconomic consequences due to the lack of organized screening programs. The success of screening programs depends on the appropriate investigation and m…
View article: Canadian Guideline on the Management of a Positive Human Papillomavirus Test and Guidance for Specific Populations
Canadian Guideline on the Management of a Positive Human Papillomavirus Test and Guidance for Specific Populations Open
The purpose of this paper is to provide evidence-based guidance on the management of a positive human papilloma virus (HPV) test and to provide guidance around screening and HPV testing for specific patient populations. The guideline was d…
View article: Enhancing cervical and breast cancer training in Africa with e-learning
Enhancing cervical and breast cancer training in Africa with e-learning Open
The African continent carries a high share of the global cancer burden, with cervical and breast cancers being the main drivers of cancer-related morbidity and mortality in the region.1Bray F Parkin DM Gnangnon F et al.Cancer in sub-Sahara…
View article: Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy women
Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy women Open
Most estetrol/drospirenone users experience a predictable and regular bleeding pattern. Providers can educate patients about the expected bleeding patterns and should advise users that they may infrequently experience no scheduled bleeding…
View article: Estetrol-drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results
Estetrol-drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results Open
A new oral contraceptive with a novel estrogen, estetrol, combined with drospirenone has efficacy and safety within the range of other available oral contraceptives. Large phase 4 studies will be needed to confirm if this combination is as…
View article: Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV‐16/18 antibodies
Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV‐16/18 antibodies Open
Background Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree of protection from naturally acquired anti‐HPV antibodies is uncertain. We examined the risk of HPV infectio…
View article: Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV‐16/18 antibodies
Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV‐16/18 antibodies Open
Background Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree of protection from naturally acquired anti‐HPV antibodies is uncertain. We examined the risk of HPV infectio…
View article: Using Earth observation images to inform risk assessment and mapping of climate change-related infectious diseases
Using Earth observation images to inform risk assessment and mapping of climate change-related infectious diseases Open
The number of human cases of several climate-related infectious diseases, including tick- and mosquito-borne diseases, has increased in Canada and other parts of the world since the end of the last century. Predicting and mapping the risks…
View article: Increased risk of tick-borne diseases with climate and environmental changes
Increased risk of tick-borne diseases with climate and environmental changes Open
Climate warming and other environmental changes have contributed to the expansion of the range of several tick species into higher latitudes in North America. As temperatures increase in Canada, the environment becomes more suitable for ti…
View article: International Anal Neoplasia Society Guidelines for the Practice of Digital Anal Rectal Examination
International Anal Neoplasia Society Guidelines for the Practice of Digital Anal Rectal Examination Open
Objective The aim of the study was to develop recommended techniques and quality assurance metrics for the practice of Digital Anal Rectal Examination (DARE). Materials and Methods The International Anal Neoplasia Society undertook a liter…
View article: Age at last screening and remaining lifetime risk of cervical cancer in older, unvaccinated women: a modelling study
Age at last screening and remaining lifetime risk of cervical cancer in older, unvaccinated women: a modelling study Open
Canadian Institutes of Health Research.
View article: Consistency of Effect with a Low-Dose, Estradiol Vaginal Capsule (TX-004HR): Evaluating Improvement in Vaginal Physiology and Moderate-to-Severe Dyspareunia in Subgroups of Postmenopausal Women
Consistency of Effect with a Low-Dose, Estradiol Vaginal Capsule (TX-004HR): Evaluating Improvement in Vaginal Physiology and Moderate-to-Severe Dyspareunia in Subgroups of Postmenopausal Women Open
TX-004HR was efficacious for treating symptomatic VVA, and it demonstrated a consistency of effect when women's age, BMI, uterine status, pregnancy status, and vaginal births were evaluated. Clinical Trial Identifier: NCT02253173.
View article: Evaluating the submission of digital images as a method of surveillance for <i>Ixodes scapularis</i> ticks
Evaluating the submission of digital images as a method of surveillance for <i>Ixodes scapularis</i> ticks Open
SUMMARY Widespread access to the internet is offering new possibilities for data collection in surveillance. We explore, in this study, the possibility of using an electronic tool to monitor occurrence of the tick vector of Lyme disease, I…
View article: 2016 IANS International Guidelines for Practice Standards in the Detection of Anal Cancer Precursors
2016 IANS International Guidelines for Practice Standards in the Detection of Anal Cancer Precursors Open
Objectives To define minimum standards for provision of services and clinical practice in the investigation of anal cancer precursors. Methods After initial face to face meetings of experts at the International Papillomavirus meeting in Li…
View article: Phase II studies to select the formulation of a multivalent HPV L1 virus-like particle (VLP) vaccine
Phase II studies to select the formulation of a multivalent HPV L1 virus-like particle (VLP) vaccine Open
Our objective was to develop a multivalent prophylactic HPV vaccine that protects against infection and disease caused by HPV16/18 (oncogenic types in existing prophylactic vaccines) plus additional oncogenic types by conducting 3 Phase II…
View article: A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women
A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women Open
The 9vHPV vaccine prevented infection and disease related to HPV-31, 33, 45, 52, and 58 in a susceptible population and generated an antibody response to HPV-6, 11, 16, and 18 that was noninferior to that generated by the qHPV vaccine. The…