Colin Funk
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View article: Neonatal fecal abundance of <i>Bifidobacterium longum</i> subspecies <i>infantis</i> is not associated with anthropometric outcomes up to 6 months of age in Bangladeshi infants
Neonatal fecal abundance of <i>Bifidobacterium longum</i> subspecies <i>infantis</i> is not associated with anthropometric outcomes up to 6 months of age in Bangladeshi infants Open
Background Bifidobacterium longum subspecies infantis ( B. infantis ) abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is…
View article: Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood
Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood Open
View article: Neonatal administration of <i>Lactiplantibacillus plantarum</i> ATCC 202195 with or without fructooligosaccharide in Bangladesh: a placebo-controlled randomized trial
Neonatal administration of <i>Lactiplantibacillus plantarum</i> ATCC 202195 with or without fructooligosaccharide in Bangladesh: a placebo-controlled randomized trial Open
Lactiplantibacillus plantarum ATCC 202195 (LP202195) plus fructooligosaccharide (FOS) for 7 days was previously shown to colonize the infant intestine up to 6 months of age and reduced sepsis rates among young infants in rural India. In a …
View article: E-211 Association of cerebrovascular injury and secondary vascular insult with poor outcomes following gunshot wound to the head in a large civilian population
E-211 Association of cerebrovascular injury and secondary vascular insult with poor outcomes following gunshot wound to the head in a large civilian population Open
Background and Objectives Cerebrovascular injury (CVI) following civilian gunshot wound to the head (GSWH) is likely a significant contributor to poor outcomes, but little supporting evidence exists. The purpose of this study was to determ…
View article: Cardioprotection by Peroxidase Activity of Prostaglandin H Synthases in Ischemia/Reperfusion Injury
Cardioprotection by Peroxidase Activity of Prostaglandin H Synthases in Ischemia/Reperfusion Injury Open
View article: Target Product Profile Analysis of COVID-19 Vaccines in Phase III Clinical Trials and Beyond: An Early 2021 Perspective
Target Product Profile Analysis of COVID-19 Vaccines in Phase III Clinical Trials and Beyond: An Early 2021 Perspective Open
The coronavirus SARS-CoV-2, which causes Coronavirus disease 2019 (COVID-19), has infected more than 100 million people globally and caused over 2.5 million deaths in just over one year since its discovery in Wuhan, China in December 2019.…
View article: A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes
A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting Leukotrienes Open
SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) has wreaked havoc during the global pandemic of 2020 infecting millions and leaving over a half million dead. As a new virus, not previously in the human population, but with similarit…
View article: A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic Open
A novel coronavirus SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) has entered the human population and has spread rapidly around the world in the first half of 2020 causing a global pandemic. The virus uses its spike glycoprotein …
View article: Perivascular adipose tissue–derived extracellular vesicle miR‐221‐3p mediates vascular remodeling
Perivascular adipose tissue–derived extracellular vesicle miR‐221‐3p mediates vascular remodeling Open
Adipose tissue–secreted extracellular vesicles (EVs) containing microRNAs (miRNAs) convey intercellular message signaling. The biogenesis of EV‐miRNAs from perivascular adipose tissue (PVAT) and their roles in intercellular communication i…
View article: Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions
Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions Open
View article: Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy
Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy Open
View article: Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin‐synthetic capacity under basal conditions
Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin‐synthetic capacity under basal conditions Open
The distinct functions of each cyclooxygenase (COX) isoform in renal homeostasis have been the subject of intense investigation for many years. We took the novel approach of using 3 characterized mouse lines, where the prostaglandin (PG)‐e…
View article: Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice
Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice Open
Progress in gene editing research has been accelerated by utilizing engineered nucleases in combination with induced pluripotent stem cell (iPSC) technology. Here, we report transcription activator-like effector nuclease (TALEN)-mediated r…
View article: Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice ,
Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice , Open
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We…
View article: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions ,
Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions , Open
View article: Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice
Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice Open
Background and Purpose An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti‐inflammatory and pro‐resolution lipid mediator derived from eicosapentaenoic…
View article: Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency Open
View article: Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice
Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice Open
In vitro and in vivo evidence has indicated that the tumor suppressor, p53, may play a significant role in the regulation of atherosclerotic plaque formation. In vivo studies using global knockout mice models, however, have generated incon…
View article: Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency
Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency Open
Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver. We previously generated a tamoxifen-inducible Arg1 deficient mouse model (Arg1-Cre) that disrupts Arg1 expression throughout the whole…
View article: Strategies to Rescue the Consequences of Inducible Arginase-1 Deficiency in Mice
Strategies to Rescue the Consequences of Inducible Arginase-1 Deficiency in Mice Open
Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body. Arginase-1 deficiency leads to hyperargininemia in mice and man with severe letha…
View article: Endogenously Generated Omega‐3 Fatty Acids Attenuate Vascular Inflammation and Neointimal Hyperplasia by Interaction With Free Fatty Acid Receptor 4 in Mice
Endogenously Generated Omega‐3 Fatty Acids Attenuate Vascular Inflammation and Neointimal Hyperplasia by Interaction With Free Fatty Acid Receptor 4 in Mice Open
Background Omega‐3 polyunsaturated fatty acids (ω3 PUFA s) suppress inflammation through activation of free fatty acid receptor 4 ( FFAR 4), but this pathway has not been explored in the context of cardiovascular disease. We aimed to eluci…
View article: EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling
EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling Open
Pulmonary arterial hypertension (PAH) is commonly associated with chronic hypoxemia in disorders such as chronic obstructive pulmonary disease (COPD). Prostacyclin analogs are widely used in the management of PAH patients; however, clinica…