Céline E. Riera
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View article: The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits
The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits Open
Aging disrupts physiological homeostasis, impairing thermoregulation, metabolism, and water balance, but the underlying neural mechanisms remain unclear. Here, we identify arginine vasopressin (AVP) neurons in the supraoptic nucleus (SON) …
View article: Wiring the Brain for Wellness: Sensory Integration in Feeding and Thermogenesis: A Report on Research Supported by Pathway to Stop Diabetes
Wiring the Brain for Wellness: Sensory Integration in Feeding and Thermogenesis: A Report on Research Supported by Pathway to Stop Diabetes Open
The recognition of sensory signals from within the body (interoceptive) and from the external environment (exteroceptive), along with the integration of these cues by the central nervous system, plays a crucial role in maintaining metaboli…
View article: Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis
Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis Open
The pathogenesis of atherosclerosis is defined by impaired lipid handling by macrophages which increases intracellular lipid accumulation. This dysregulation of macrophages triggers the accumulation of apoptotic cells and chronic inflammat…
View article: A sex-specific thermogenic neurocircuit induced by stressful olfactory inputs.
A sex-specific thermogenic neurocircuit induced by stressful olfactory inputs. Open
When detecting danger signals, animals exhibit adaptive changes in physiology and behavior aimed at increasing survival. In small prey animals, such as rodents, olfactory information plays a fundamental role in the perception of their envi…
View article: PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c Open
The double-stranded RNA-dependent protein kinase activating protein (PACT), an RNA-binding protein that is part of the RNA-induced silencing complex, plays a key role in miR-mediated translational repression. Previous studies showed that P…
View article: Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy
Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy Open
Dopaminergic neuron degeneration in the midbrain plays a pivotal role in motor symptoms associated with Parkinson’s disease. However, non-motor symptoms of Parkinson’s disease and post-mortem histopathology confirm dysfunction in other bra…
View article: Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study
Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study Open
Objective We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers. Design Observational cohort study of healthcare workers, including SARS-…
View article: Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity
Sensory neurons expressing calcitonin gene-related peptide α regulate adaptive thermogenesis and diet-induced obesity Open
Taken together, these findings highlight an important role of cutaneous thermoreceptors in regulating energy metabolism by triggering counter-regulatory responses involving energy dissipation processes including lipid fuel utilization and …
View article: Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes?
Can Monoclonal Antibodies against CGRP Offer New Treatment Options for Type 2 Diabetes? Open
The neuropeptide Calcitonin Gene-Related Peptide (CGRP) is a 37-amino acid peptide, with a wide-range of biological activities including vasodilation, neurogenic inflammation, immune function and hypertension. In addition to these various …
View article: SARS-CoV-2 Seroprevalence in Relation to Timing of Symptoms
SARS-CoV-2 Seroprevalence in Relation to Timing of Symptoms Open
Of individuals with SARS-CoV-2 IgG antibody testing performed, those who contemporaneously experienced a cluster of Covid-19 relevant symptoms in the 1-2 months preceding the antibody assay were more likely to test positive whereas those w…
View article: SARS-CoV-2 Seroprevalence Across a Diverse Cohort of Healthcare Workers
SARS-CoV-2 Seroprevalence Across a Diverse Cohort of Healthcare Workers Open
Importance Antibody testing is important for understanding patterns of exposure and potential immunity to SARS-CoV-2. Prior data on seroprevalence have been subject to variations in selection of individuals and nature as well as timing of …
View article: Sense of Smell as the Central Driver of Pavlovian Appetite Behavior in Mammals
Sense of Smell as the Central Driver of Pavlovian Appetite Behavior in Mammals Open
The seminal experiments of Ivan Petrovich Pavlov set the stage for an understanding of the physiological concomitants of appetite and feeding behavior. His findings, from careful and creative experimentation, have been uncontested for over…
View article: Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging
Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging Open
Preservation of mitochondrial function, which is dependent on mitochondrial homeostasis (biogenesis, dynamics, disposal/recycling), is critical for maintenance of skeletal muscle function. Skeletal muscle performance declines upon aging (s…