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View article: Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy Open
Background Skin biopsy is a potential tool for the premortem confirmation of an α‐synucleinopathy. Objective The aim was to assess the aggregation assay real‐time quaking‐induced conversion (RT‐QuIC) of skin biopsy lysates to confirm isola…
View article: Combining skin and olfactory α-synuclein RT-QuIC - towards biomarker-driven phenotyping in synucleinopathies
Combining skin and olfactory α-synuclein RT-QuIC - towards biomarker-driven phenotyping in synucleinopathies Open
Seeding assays, such as real-time quaking-induced conversion (RT-QuIC), are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) h…