Céline Vallot
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View article: 130MO Single-cell molecular profiling of metastatic urothelial carcinoma under immune checkpoint blockade
130MO Single-cell molecular profiling of metastatic urothelial carcinoma under immune checkpoint blockade Open
View article: 128O Evolution of transcriptomic and epigenomic intra-tumor heterogeneity in high-grade serous ovarian cancer with chemotherapy
128O Evolution of transcriptomic and epigenomic intra-tumor heterogeneity in high-grade serous ovarian cancer with chemotherapy Open
View article: Proneural–mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import
Proneural–mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import Open
Background Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GB…
View article: Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis
Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis Open
View article: IDclust: Iterative clustering for unsupervised identification of cell types with single cell transcriptomics and epigenomics
IDclust: Iterative clustering for unsupervised identification of cell types with single cell transcriptomics and epigenomics Open
The increasing diversity of single-cell datasets require systematic cell type characterization. Clustering is a critical step in single-cell analysis, heavily influencing downstream analyses. However, current unsupervised clustering algori…
View article: Kernel-based testing for single-cell differential analysis
Kernel-based testing for single-cell differential analysis Open
View article: Kernel-Based Testing for Single-Cell Differential Analysis
Kernel-Based Testing for Single-Cell Differential Analysis Open
Single-cell technologies offer insights into molecular feature distributions, but comparing them poses challenges. We propose a kernel-testing framework for non-linear cell-wise distribution comparison, analyzing gene expression and epigen…
View article: A benchmark of computational pipelines for single-cell histone modification data
A benchmark of computational pipelines for single-cell histone modification data Open
View article: Data for "A benchmark of computational pipelines for single-cell histone modification data"
Data for "A benchmark of computational pipelines for single-cell histone modification data" Open
The `time_features.txt` and `time_correct.txt` files contain the runtimes for the various embedding methods. The .csv files contain the computed scores (both supervised and unsupervised) for all the methods.
View article: Data for "A benchmark of computational pipelines for single-cell histone modification data"
Data for "A benchmark of computational pipelines for single-cell histone modification data" Open
The `time_features.txt` and `time_correct.txt` files contain the runtimes for the various embedding methods. The .csv files contain the computed scores (both supervised and unsupervised) for all the methods.
View article: Supplementary Figure Legends 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Figure Legends 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Figure Legends 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Supplementary Table 2 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Table 2 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Table 2 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Data from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Data from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
The 8p11-12 chromosome region is one of the regions most frequently amplified in breast carcinoma (10–15% of cases). Several genes within this region have been identified as candidate oncogenes, as they are both amplified and overexpressed…
View article: Data from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Data from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
The 8p11-12 chromosome region is one of the regions most frequently amplified in breast carcinoma (10–15% of cases). Several genes within this region have been identified as candidate oncogenes, as they are both amplified and overexpressed…
View article: Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Supplementary Table 2 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Table 2 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Table 2 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Figures 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Supplementary Table 1 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Table 1 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Table 1 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Supplementary Figure Legends 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Figure Legends 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Figure Legends 1-4 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Supplementary Table 1 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
Supplementary Table 1 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer Open
Supplementary Table 1 from Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer
View article: Multi-modal quantification of pathway activity with MAYA
Multi-modal quantification of pathway activity with MAYA Open
View article: Evolution of synchronous female bilateral breast cancers and response to treatment
Evolution of synchronous female bilateral breast cancers and response to treatment Open
View article: Best practices for single-cell histone modification analysis
Best practices for single-cell histone modification analysis Open
Background Single-cell histone post translation modification (scHPTM) assays such as scCUT&Tag or scChIP-seq allow single-cell mapping of diverse epigenomic landscapes within complex tissues, and are likely to unlock our understanding of v…
View article: Multi-modal quantification of pathway activity with MAYA
Multi-modal quantification of pathway activity with MAYA Open
Signaling pathways can be activated through various cascades of genes depending on cell identity and biological context. Single-cell atlases now provide the opportunity to inspect such complexity in health and disease. Yet, existing refere…
View article: Luminal progenitors undergo partial epithelial-to-mesenchymal transition at the onset of basal-like breast tumorigenesis
Luminal progenitors undergo partial epithelial-to-mesenchymal transition at the onset of basal-like breast tumorigenesis Open
SUMMARY Defects in double-strand repair mechanisms - both through germline or somatic inactivation of repair genes - is a hallmark of basal-like breast cancers. In this genetically-unstable context, a recurrent shift in cell identity occur…
View article: Epigenomic tumor evolution under the spotlight: the promises of single-cell approaches
Epigenomic tumor evolution under the spotlight: the promises of single-cell approaches Open
Cancer evolution was long-reduced to a genetic equation. The latest technological and subsequent conceptual advances, catalyzed by single-cell approaches, now begin to reveal the long-suspected part played by epigenomic and transcriptomic …
View article: La chromatine bivalente préserve la plasticité transcriptionnelle
La chromatine bivalente préserve la plasticité transcriptionnelle Open
International audience
View article: H3K27me3 conditions chemotolerance in triple-negative breast cancer
H3K27me3 conditions chemotolerance in triple-negative breast cancer Open
View article: Evolution of synchronous bilateral breast cancers provide insights into interactions between host, tumor and immunity
Evolution of synchronous bilateral breast cancers provide insights into interactions between host, tumor and immunity Open
Synchronous bilateral breast cancer (sBBC) occurs after both breasts have been affected by the same germline genetics, reproductive life factors and environmental exposures for decades. It represents an opportunity to decipher the complex …
View article: A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression Open