Celso E. Gómez-Sánchez

Cover Image, Volume 45, Issue 6 Open

Katia Mariniello, James Pittaway, Barbara Altieri, Kleiton Silva Borges, Irene Hadjidemetriou , et al. · 2025

The cover image is based on the article Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma by James Pittaway et al., https://doi.org/10.1002/cac2.70012 . image

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma Open

Katia Mariniello, James Pittaway, Barbara Altieri, Kleiton Silva Borges, Irene Hadjidemetriou , et al. · 2025

Diálogos Insurgentes: o debate decolonial e seus reflexos na pesquisa em Educação Ambiental Open

Marcelo Aranda Stortti, Celso E. Gómez-Sánchez, Danilo Seithi Kato · 2025

Este estudo tem por objetivo analisar os artigos presentes nos anais do XI Encontro Pesquisa em Educação Ambiental, realizado em Salvador, Bahia, no ano de 2023, e as questões observadas durante as apresentações de trabalhos e das atividad…

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma Open

Katia Mariniello, James Pittaway, Barbara Altieri, Kleiton Silva Borges, Irene Hadjidemetriou , et al. · 2024

Disruption of processes involved in tissue development and homeostatic self-renewal is increasingly implicated in cancer initiation, progression, and recurrence. The adrenal cortex is a dynamic tissue that undergoes life-long turnover. Her…

Double CYP11B1/CYP11B2 Immunohistochemistry and Detection of KCNJ5 Mutations in Primary Aldosteronism Open

Brasilina Caroccia, Livia Lenzini, Giulio Ceolotto, Francesca Gioco, Andrea Benetti , et al. · 2024

Context The search for somatic mutations in adrenals resected from patients with primary aldosteronism (PA) is performed by Sanger sequencing, often implemented with immunohistochemistry (IHC)-guidance focused on aldosterone-producing (CYP…

Familial hyperaldosteronism: an European Reference Network on Rare Endocrine Conditions clinical practice guideline Open

Paolo Mulatero, Ute I. Scholl, Carlos Fardella, Evangelia Charmandari, Andrzej Januszewicz , et al. · 2024

We describe herein the European Reference Network on Rare Endocrine Conditions clinical practice guideline on diagnosis and management of familial forms of hyperaldosteronism. The guideline panel consisted of 10 experts in primary aldoster…

Investigating the cut-off values of captopril challenge test for primary aldosteronism using the novel chemiluminescent enzyme immunoassay method: a retrospective cohort study Open

Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kengo Kambara, Hiroki Kamada , et al. · 2024

The measurement evolution enabled more accurate evaluation of aldosterone production in hypertensive patients. However, the cut-off values for novel assays have been not sufficiently validated. The present study was undertaken to validate …

Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor‐Associated Hypertension Open

Zhe Ye, Ryuji Okamoto, Hiromasa Ito, Rie Ito, Keishi Moriwaki , et al. · 2024

Background Myosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation of MLC to phospho‐MLC (p‐MLC). A recent study d…

Cholesterol Availability and Adrenal Steroidogenesis Open

Celso E. Gómez-Sánchez, Elise P. Gómez-Sánchez · 2024

Steroid hormones are crucial for the regulation of many aspects of metabolism, homeostasis, 1 immune function, reproduction, and development.Cholesterol is the for the synthesis 2 of steroid by succession enzyme-catalyzed reactions.While s…

Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism Open

Desmaré van Rooyen, Antônio Marcondes Lerário, Donald W. Little, Matthew Ullenbruch, Matthew Taylor , et al. · 2024

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms Open

Yusuf Ali, Celso E. Gómez-Sánchez, Maria W. Plonczynski, Anikó Náray‐Fejes‐Tóth, Géza Fejes‐Tóth , et al. · 2024

The mineralocorticoid receptor (MR) is a transcription factor for genes mediating diverse, cell-specific functions, including trophic effects as well as promoting fluid/electrolyte homeostasis. It was reported that in intercalated cells, p…

Retirada y reintroducción del tratamiento farmacológico de la epilepsia en pacientes pediátricos. Nuestra experiencia Open

Patricia Morte-Coscolín, Celso E. Gómez-Sánchez, Javier López Pisón, M V Fariña-Jara, F F Martínez-Calvo , et al. · 2024

The decision to withdraw treatment must be personalised, and consider the risk of relapse, taking into account efficacy and tolerability, and behaviour and neurodevelopment in particular.

FRI166 Characterization of Aldosterone-producing Cell Cluster (APCC) At Single-cell Resolution Open

Norifusa Iwahashi, Hironobu Umakoshi, Tsugio Seki, Celso E. Gómez-Sánchez, Kuniaki Mukai , et al. · 2023

Disclosure: N. Iwahashi: None. H. Umakoshi: None. T. Seki: None. C. Gomez-Sanchez: None. K. Mukai: None. M. Suematsu: None. Y. Umezawa: None. M. Oya: None. T. Kosaka: None. M. Seki: None. Y. Suzuki: None. Y. Horiuchi: None. K. Nishimoto: N…

FRI161 An in Vitro Triple Screen Model for Human Mineralocorticoid Receptor Activity Open

Haiping Liu, Sonja Konzen, A. Coy, Juilee Rege, Celso E. Gómez-Sánchez , et al. · 2023

Disclosure: H. Liu: None. S.M. Konzen: None. A. Coy: None. J. Rege: None. C.E. Gomez-Sanchez: None. W.E. Rainey: None. A.F. Turcu: None. Background: The mineralocorticoid receptor (MR, NR3C2) mediates ion and water homeostasis in epithelia…

Distinct adrenal gland macrophages regulate corticosteroid production Open

Conan J O O’Brien, Davi Sidarta-Oliveira, Aleksander Stawiarski, Giorgio Ratti, Pierre-Louis Loyher , et al. · 2023

Summary The adrenal glands are hormone secreting glands that sit on top of the kidneys. Adrenal glands produce glucocorticoids, mineralocorticoids, and catecholamines, and are therefore critical regulators of the stress response, the immun…

Metastatic Merkel Cell Carcinoma Within a Cortisol-producing Adrenal Adenoma Open

Lauren S Cutrone, José S. Subauste, Celso E. Gómez-Sánchez, Sarah Joiner · 2023

A 54-year-old man with hypertension, type 2 diabetes mellitus, and a history of Merkel cell carcinoma (MCC) of the right thigh presented to the emergency department with a 4-day history of right lower-quadrant abdominal pain associated wit…

18-Oxocortisol: A journey Open

Celso E. Gómez-Sánchez, Elise P. Gómez-Sánchez · 2023

Aldosterone Synthase Inhibitors and the Treatment of Essential Hypertension Open

Celso E. Gómez-Sánchez, Elise P. Gómez-Sánchez · 2023

Journal Article Aldosterone Synthase Inhibitors and the Treatment of Essential Hypertension Get access Celso E Gomez-Sanchez, Celso E Gomez-Sanchez G. V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jacks…

Distinct Adrenal Gland Macrophages Regulate Corticosteroid Production Open

Conan James Oliver O'Brien, Davi Sidarta-Oliveira, Aleksander Stawiarski, Giorgio Ratti, Pierre-Louis Loyher , et al. · 2023

In Situ Metabolomics of Cortisol-Producing Adenomas Open

Masanori Murakami, Na Sun, Fengxia Li, Annette Feuchtinger, Celso E. Gómez-Sánchez , et al. · 2022

Received June 8, 2022; accepted October 11, 2022 Background Recent advances in omics techniques have allowed detailed genetic characterization of cortisol-producing adrenal adenoma (CPA). In contrast, the pathophysiology of CPAs has not be…

Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells Open

Yusuf Ali, Elise P. Gómez-Sánchez, Celso E. Gómez-Sánchez · 2022

Background Mammalian target of rapamycin (mTOR) inhibitors suppress adrenal cortical carcinoma cell proliferation and cortisol production; the relationship between mTOR and aldosterone production has not been examined. Methods HAC15 cells …

OR26-2 mTOR Interacts with the Mineralocorticoid Receptor to Regulate its Activation by Ligand Open

Celso E. Gómez-Sánchez, Elise P. Gómez-Sánchez, Yusuf Ali · 2022

Background Phosphorylation of the mineralocorticoid receptor (MR) at serine 843 inhibits its activity. mTOR phosphorylation of ULK1 prevents this MR phosphorylation. Purpose To study the relationship between mTOR and MR and its role in the…

Primary aldosteronism caused by a pI157S somatic KCNJ5 mutation in a black adolescent female with aldosterone-producing adenoma Open

Celso E. Gómez-Sánchez, Desmaré van Rooyen, William E. Rainey, Kazutaka Nanba, Amy Blinder , et al. · 2022

Aldosterone-producing adenoma is a rare cause of hypertension in children. Only a limited number of cases of aldosterone-producing adenomas with somatic KCNJ5 gene mutations have been described in children. Blacks are particularly more sus…

Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron Open

Brandi M. Wynne, Trinity K. Samson, Hayley Catherine Moyer, Henrieke J. van Elst, Auriel Moseley , et al. · 2022

Hypertension is characterized by increased sodium (Na + ) reabsorption along the aldosterone-sensitive distal nephron (ASDN) as well as chronic systemic inflammation. Interleukin-6 (IL-6) is thought to be a mediator of this inflammatory pr…

Origin of circulating 18-oxocortisol in the normal human adrenal Open

Celso E. Gómez-Sánchez, Dina R. Sapiro, Katie V. May, William E. Rainey, Koshiro Nishimoto , et al. · 2022

Characterization of Aldosterone-producing Cell Cluster (APCC) at Single-cell Resolution Open

Norifusa Iwahashi, Hironobu Umakoshi, Tsugio Seki, Celso E. Gómez-Sánchez, Kuniaki Mukai , et al. · 2022

Context The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and reticularis. Aldosterone-producing cell clusters (APCCs) that strongly express aldosterone synthase (CYP11B2) are frequently found in adult adrenals and ha…

Association of DNA methylation with steroidogenic enzymes in Cushing’s adenoma Open

Takaya Kodama, Kenji Oki, Yu Otagaki, Ryuta Baba, Akira Okada , et al. · 2022

DNA methylation and demethylation regulate the transcription of genes. DNA methylation-associated gene expression of adrenal steroidogenic enzymes may regulate cortisol production in cortisol-producing adenoma (CPA). We aimed to determine …

11C-Metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial Open

Troy Puar, Chin Meng Khoo, Colin Jingxian Tan, Aaron Kian Ti Tong, Michael Chien Sheng Tan , et al. · 2022

Objective: Adrenal vein sampling (AVS) is recommended to subtype primary aldosteronism, but it is technically challenging. We compared 11 C-Metomidate-PET-computed tomography (PET-CT) and AVS for subtyping of primary aldosteronism. Methods…

Review of: "Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking zonal transdifferentiation" Open

Celso E. Gómez-Sánchez · 2022

Potential competing interests: The author(s) declared that no potential competing

Guía para el manejo del Aldosteronismo Primario Open

Celso E. Gómez-Sánchez · 2022

El aldosteronismo primario es la causa de hipertensión secundaria más común que afecta entre 5-24% de los pacientes con hipertensión arterial y está asociada a un incremento de la morbilidad cardiovascular, cerebrovascular y renal comparad…

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