Explanipedia

Lymphopenia predicts poor outcomes in newly diagnosed multiple myeloma Open

Grace Ferri, Cenk Yildirim, Nhan Do, Mary T. Brophy, Joseph Park , et al. · 2024

Bone marrow microenvironment plays an important role in promoting growth and survival of multiple myeloma (MM) cells. The tumor-promoting immune microenvironment is augmented while antitumor immune responses are inhibited. Although clinica…

Validation of algorithms to select patients with multiple myeloma and patients initiating myeloma treatment in the national Veterans Affairs Healthcare System Open

Jennifer La, Clark DuMontier, Hamza Hassan, Maya Abdallah, Camille V. Edwards , et al. · 2022

Background We aimed to evaluate and compare the performance of multiple myeloma (MM) selection algorithms for use in Veterans Affairs (VA) research. Methods Using the VA Corporate Data Warehouse (CDW), the VA Cancer Registry (VACR), and VA…

Corrigendum to: Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10 Open

David Cheng, Clark DuMontier, Cenk Yildirim, Brian Charest, Chelsea E. Hawley , et al. · 2021

Contemporary Analysis of Electronic Frailty Measurement in Older Adults with Multiple Myeloma Treated in the National US Veterans Affairs Healthcare System Open

Clark DuMontier, Nathanael R. Fillmore, Cenk Yildirim, David Cheng, Jennifer La , et al. · 2021

Electronic frailty indices based on data from administrative claims and electronic health records can be used to estimate frailty in large populations of older adults with cancer where direct frailty measures are lacking. The objective of …

Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10 Open

David Cheng, Clark DuMontier, Cenk Yildirim, Brian Charest, Chelsea E. Hawley , et al. · 2021

Background The Veterans Affairs Frailty Index (VA-FI) is an electronic frailty index developed to measure frailty using administrative claims and electronic health records data in Veterans. An update to ICD-10 coding is needed to enable co…

Safety of in-utero antiretroviral exposure: neurologic outcomes in children who are HIV-exposed but uninfected Open

Claudia S. Crowell, Paige L. Williams, Cenk Yildirim, Russell B. Van Dyke, Renee Smith , et al. · 2020

Objective: To evaluate whether there is an increased risk of neurologic diagnoses in children who are HIV-exposed but uninfected (CHEU) exposed in utero to specific antiretroviral medications. Design: Prospective cohort study of CHEU enrol…

Association of maternal antiretroviral use with microcephaly in children who are HIV-exposed but uninfected (SMARTT): a prospective cohort study Open

Paige L. Williams, Cenk Yildirim, Ellen G. Chadwick, Russell B. Van Dyke, Renee Smith , et al. · 2019

364. Association of Maternal ARV Use with Microcephaly in HIV-Exposed Uninfected Children Open

Paige L. Williams, Cenk Yildirim, Ellen G. Chadwick, Russell B. Van Dyke, Renee Smith , et al. · 2019

Background Perinatal HIV transmission has dramatically decreased with combination antiretroviral (ARV) regimens, but complications among HIV-exposed uninfected (HEU) children, such as microcephaly, warrant ongoing surveillance. Methods We …

The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV) Open

Cenk Yildirim, Patricia A. Garvie, Miriam Chernoff, Megan L. Wilkins, E. Doyle Patton , et al. · 2019

LB5. Safety of In Utero Antiretroviral (ARV) Exposure: Neurologic Outcomes in HIV-Exposed, Uninfected Children Open

Claudia S. Crowell, Paige L. Williams, Cenk Yildirim, Russell Van Dyke, Renee Smith , et al. · 2018

Background Antiretroviral therapy for pregnant women with HIV has dramatically decreased perinatal transmission of HIV, but concerns remain regarding adverse neurologic outcomes from possible mitochondrial dysfunction or other mechanisms i…

Prospective memory in youth with perinatally-acquired HIV infection Open

Lynnette Harris, Miriam C. Chernoff, Sharon Nichols, Paige L. Williams, Patricia A. Garvie , et al. · 2017

Youth with perinatal HIV infection (PHIV) are at increased risk for neurocognitive impairment (NCI). Prospective memory (PM) is a complex neurocognitive function that has been shown to be impaired in adults with HIV disease and independent…

Impact of Perinatally Acquired HIV Disease Upon Longitudinal Changes in Memory and Executive Functioning Open

Kathleen Malee, Miriam C. Chernoff, Patricia A. Sirois, Paige L. Williams, Patricia A. Garvie , et al. · 2017

Background: Little is known regarding effects of perinatally acquired HIV infection (PHIV) on longitudinal change in memory and executive functioning (EF) during adolescence despite the importance of these skills for independence in adulth…

Associations of Memory and Executive Functioning With Academic and Adaptive Functioning Among Youth With Perinatal HIV Exposure and/or Infection Open

Patricia A. Sirois, Miriam C. Chernoff, Kathleen Malee, Patricia A. Garvie, Lynnette Harris , et al. · 2016

Higher-order cognitive abilities such as memory and EF seem to play a key role in academic and adaptive capacities, regardless of a child's HIV status, and might serve as intervention targets for improving functional outcomes.

Executive Functioning in Children and Adolescents With Perinatal HIV Infection and Perinatal HIV Exposure Open

Sharon Nichols, Miriam C. Chernoff, Kathleen Malee, Patricia A. Sirois, Steven Paul Woods , et al. · 2016

Youth with PHIV and previous AIDS-defining conditions performed more poorly on some EF measures. Relationships of EF development with the degree and timing of disease severity require further study. Implications for long-term outcomes and …

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