Explanipedia

The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs Open

Treg Grubb, Pooneh Koochaki, Sayed Matar, Fatme Ghandour, Eddy Saad , et al. · 2025

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer Open

Sonia Boscenco, Jacqueline Tait-Mulder, Minsoo Kim, Cerise Tang, Tricia Park , et al. · 2025

62The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs Open

Treg Grubb, Pooneh Koochaki, Sayed Matar, Fatme Ghandour, Marc Machaalani , et al. · 2025

Background Epigenetic dysregulation, including accumulation of Histone H3 lysine 27 acetylation (H3K27ac), is a hallmark of pVHL-deficient clear cell Renal Cell Carcinomas (ccRCCs). H3K27ac is associated with transcriptional activation and…

40Investigating the determinants of immunotherapy response in the primary tumor of clear cell renal cell carcinoma (RCC) Open

Cerise Tang, Deepak Poduval, R. Rout, Suzanna Lee, Justine Panian , et al. · 2025

Background While previous studies have examined the determinants of a patient’s overall response to immune checkpoint inhibitor (ICI) in advanced RCC, the factors that specifically influence ICI response in the primary tumor remain poorly …

Scaling Large Language Models for Next-Generation Single-Cell Analysis Open

Syed Asad Rizvi, Daniel Lévine, Aakash Patel, Shiyang Zhang, Eric W. Wang , et al. · 2025

A bstract Single-cell RNA sequencing has transformed our understanding of cellular diversity, yet current single-cell foundation models (scFMs) remain limited in their scalability, flexibility across diverse tasks, and ability to natively …

Obesity-dependent selection of driver mutations in cancer Open

Cerise Tang, Venise Jan Castillon, Michele Waters, Chris Fong, Tricia Park , et al. · 2024

Sample Site Impacts RNA Biomarkers for Renal Cell Carcinoma Open

Lennert Eismann, Amy Xie, Cerise Tang, Andrea Knežević, Irina Ostrovnaya , et al. · 2024

Immunotherapy (ICIs) remains a mainstay for treatment of advanced clear-cell renal cell carcinoma (ccRCC). Biomarker analyses have demonstrated that gene expression profiles are associated with regimen-specific outcomes. These transcriptom…

Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes Open

Minsoo Kim, Alexander N. Gorelick, Ignacio Vázquez-Garćıa, Marc Williams, Sohrab Salehi , et al. · 2024

Obesity shapes selection for driver mutations in cancer Open

Cerise Tang, Venise Jan Castillon, Michele Waters, Chris Fong, Tricia Park , et al. · 2024

Obesity is a leading risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. Here, we examined the relationship between obesity and tumor genotype in two large clinicogenomic corpora. Obesit…

The<i>SLC1A1</i>/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs Open

Treg Grubb, Jesminara Khatun, Sayed Matar, Fatme Ghandour, Noah Dubasik , et al. · 2023

Inactivation of pVHL tumor suppressor in clear cell Renal Cell Carcinoma (ccRCC) increases the abundance of Histone H3 lysine 27 acetylation (H3K27ac). We hypothesized that H3K27ac, a marker of transcriptional activation, drives the expres…

Functional and translational consequences of immunometabolic coevolution in ccRCC Open

Ed Reznik, Cerise Tang, Amy Xie, Eric Minwei Liu, Fengshen Kuo , et al. · 2023

Background Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic consequences remain poorly understood. In vitro mechanistic st…

2023 Kidney Cancer Research Summit Abstracts Open

Georges Gebrael, Ged Mbbs, Irina Rifkind, Lori Tony, Keegan Daugherty , et al. · 2023

The 5th Kidney Cancer Research Summit (KCRS) took place on July 13th & 14th, 2023 as a hybrid event both in Boston, Massachusetts at the InterContinental Boston, and virtually via Zoom webinar. The conference format consisted of oral prese…

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy Xie, Eric Minwei Liu, Fengshen Kuo, Min‐Soo Kim , et al. · 2023

Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic consequences remain poorly understood. To study IMH, we profiled tumor/no…

A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation Open

Elisa Benedetti, Eric Minwei Liu, Cerise Tang, Fengshen Kuo, Mustafa Büyüközkan , et al. · 2023

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy X. Xie, Minwei Liu, Fengshen Kuo, Min‐Soo Kim , et al. · 2023

Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy Xie, Minwei Liu, Fengshen Kuo, Min‐Soo Kim , et al. · 2023

Data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC". Supplemental Table 1: Metabolic Features of Necrotic Outliers Supplemental Table 2: Data Matrices and Sample Information Supplemental Tab…

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy Xie, Minwei Liu, Fengshen Kuo, Minsoo Kim , et al. · 2023

Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy Xie, Minwei Liu, Fengshen Kuo, Min‐Soo Kim , et al. · 2023

Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy X. Xie, Minwei Liu, Fengshen Kuo, Minsoo Kim , et al. · 2023

Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".

Immunometabolic coevolution defines unique microenvironmental niches in ccRCC Open

Cerise Tang, Amy X. Xie, Minwei Liu, Fengshen Kuo, Minsoo Kim , et al. · 2023

Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC".

Additional file 1 of Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape Open

Mahdi Golkaram, Fengshen Kuo, Sounak Gupta, Maria I. Carlo, Michael Salmans , et al. · 2023

Additional file1 Supplementary Tables: Cohort characteristics, gene signature scores, ITH classification and histopathology review results

Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape Open

Mahdi Golkaram, Fengshen Kuo, Sounak Gupta, Maria I. Carlo, Michael Salmans , et al. · 2022

Background Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we seek to elucidate how ITH and tumor evolution during…

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation Open