Cesar M. Rueda
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View article: POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development
POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development Open
View article: Ataxia-Telangiectasia and Refractory Peripheral T-cell Lymphoma: Considerations for Therapy and Role of Bone Marrow Transplantation
Ataxia-Telangiectasia and Refractory Peripheral T-cell Lymphoma: Considerations for Therapy and Role of Bone Marrow Transplantation Open
Certain patients with inborn errors of immunity have defects in DNA damage response, predisposing them to malignancy. Subsequent cancer therapy may require substantial attenuation given defective DNA repair; however, this carries risk of i…
View article: Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant Open
View article: A Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors
A Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors Open
CARMIL2 deficiency is a rare combined immunodeficiency (CID) characterized by defective CD28-mediated T cell co-stimulation, altered cytoskeletal dynamics, and susceptibility to Epstein Barr Virus smooth muscle tumors (EBV-SMTs). Case repo…
View article: IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation
IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation Open
Neutrophil infiltration of the chorioamnion-decidua tissue at the maternal-fetal interface (chorioamnionitis) is a leading cause of prematurity, fetal inflammation, and perinatal mortality. We induced chorioamnionitis in preterm rhesus mac…
View article: High density lipoproteins selectively promote the survival of human regulatory T cells
High density lipoproteins selectively promote the survival of human regulatory T cells Open
HDLs appear to affect regulatory T cell (Treg) homeostasis, as suggested by the increased Treg counts in HDL-treated mice and by the positive correlation between Treg frequency and HDL-cholesterol levels in statin-treated healthy adults. H…
View article: IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells
IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells Open
View article: Type I interferons regulate susceptibility to inflammation-induced preterm birth
Type I interferons regulate susceptibility to inflammation-induced preterm birth Open
Preterm birth (PTB) is a leading worldwide cause of morbidity and mortality in infants. Maternal inflammation induced by microbial infection is a critical predisposing factor for PTB. However, biological processes associated with competenc…
View article: Intra-amniotic <i>Ureaplasma parvum</i> –Induced Maternal and Fetal Inflammation and Immune Responses in Rhesus Macaques
Intra-amniotic <i>Ureaplasma parvum</i> –Induced Maternal and Fetal Inflammation and Immune Responses in Rhesus Macaques Open
U. parvum colonized the amniotic fluid and caused uterine inflammation, but without overt chorioamnionitis. It caused mild fetal lung inflammation but had a more profound effect on the fetal immune system, decreasing Tregs and polarizing t…
View article: Regulatory T-Cell-Mediated Suppression of Conventional T-Cells and Dendritic Cells by Different cAMP Intracellular Pathways
Regulatory T-Cell-Mediated Suppression of Conventional T-Cells and Dendritic Cells by Different cAMP Intracellular Pathways Open
Regulatory T-cells (Tregs) mediate their suppressive action by acting directly on conventional T-cells (Tcons) or dendritic cells (DCs). One mechanism of Treg suppression is the increase of cyclic adenosine 3',5'-monophosphate (cAMP) level…
View article: Phenotypical characterization of regulatory T cells in humans and rodents
Phenotypical characterization of regulatory T cells in humans and rodents Open
Summary Regulatory T cells (Tregs) constitute a fascinating subpopulation of CD4+ T cells due to their ability to limit the immune response against self and non-self antigens. Murine models and antibodies directed against surface and intra…
View article: Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1–Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque
Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1–Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque Open
Chorioamnionitis is associated with preterm labor and fetal inflammatory response syndrome (FIRS), causing fetal organ injury and morbidity, particularly in extremely premature infants. However, the effects of inflammation on the fetal imm…
View article: Neonatal regulatory T cells have reduced capacity to suppress dendritic cell function
Neonatal regulatory T cells have reduced capacity to suppress dendritic cell function Open
Regulatory T cells (Treg cells) limit contact between dendritic cells (DCs) and conventional T cells (Tcons), decreasing the formation of aggregates as well as down‐modulating the expression of co‐stimulatory molecules by DCs, thus decreas…