Cesia Gonzalez
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Author Swipe
View article: Reduced efficacy of an anti-toxin vaccine from senescence-driven attenuation of toxin virulence
Reduced efficacy of an anti-toxin vaccine from senescence-driven attenuation of toxin virulence Open
It remains unclear why vaccines targeting prominent microbial virulence factors often fail in clinical trials. Because microbial virulence depends on interaction with the host immune system, we investigated how changes in host immune funct…
View article: Pathobiont-induced suppressive immune imprints thwart T cell vaccine responses
Pathobiont-induced suppressive immune imprints thwart T cell vaccine responses Open
Pathobionts have evolved many strategies to coexist with the host, but how immune evasion mechanisms contribute to the difficulty of developing vaccines against pathobionts is unclear. Meanwhile, Staphylococcus aureus (SA) has resisted hum…
View article: Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination Open
The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that…
View article: The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches
The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches Open
The failure of the Staphylococcus aureus (SA) IsdB vaccine trial can be explained by the recall of non-protective immune imprints from prior SA exposure. Here, we investigate natural human SA humoral imprints to understand their broader im…
View article: Functional divergence of a bacterial enzyme promotes healthy or acneic skin
Functional divergence of a bacterial enzyme promotes healthy or acneic skin Open
View article: Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine
Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine Open