Ching‐Hui Sia
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View article: Evaluating the LV global deformation index, a novel echocardiographic marker for prediction of heart failure in asian patients with hypertrophic cardiomyopathy
Evaluating the LV global deformation index, a novel echocardiographic marker for prediction of heart failure in asian patients with hypertrophic cardiomyopathy Open
Background A novel tissue Doppler index, termed as the left ventricular global deformation index is proposed and assessed for its relation to the prediction of heart failure hospitalization in Asian patients with hypertrophic cardiomyopath…
View article: The Contemporary Role of Cardiovascular Magnetic Resonance in Ischemic Cardiomyopathy
The Contemporary Role of Cardiovascular Magnetic Resonance in Ischemic Cardiomyopathy Open
Ischemic cardiomyopathy is the leading cause of heart failure globally. While echocardiography is the cornerstone of cardiovascular imaging, cardiovascular magnetic resonance (CMR) plays a crucial role in providing a thorough assessment of…
View article: Deep learning-based quantification of epicardial adipose tissue volume from non-contrast computed tomography images: a multi-centre study
Deep learning-based quantification of epicardial adipose tissue volume from non-contrast computed tomography images: a multi-centre study Open
Aims Epicardial adipose tissue (EAT), located within the pericardial sac, has emerged as a biomarker for coronary artery disease (CAD) progression. This study aimed to develop and validate a deep learning-based system for automated EAT vol…
View article: Clinical Characteristics, Hemodynamic Profile, and Outcomes in Patients With Low‐Gradient and High‐Gradient Severe Mitral Stenosis: Influence of Flow Status
Clinical Characteristics, Hemodynamic Profile, and Outcomes in Patients With Low‐Gradient and High‐Gradient Severe Mitral Stenosis: Influence of Flow Status Open
Background In severe mitral stenosis (MS), flow‐status was recently recognized as potentially impactful in some patients with low transmitral gradients. Methods We studied 172 patients with isolated rheumatic MS with mitral valve area ≤1.5…
View article: SUN-538 Association of Gestational Diabetes Mellitus with Metabolic Markers and Cardiovascular Risk Factors: A Meta-Analysis
SUN-538 Association of Gestational Diabetes Mellitus with Metabolic Markers and Cardiovascular Risk Factors: A Meta-Analysis Open
Disclosure: M. Tham: None. L.S. Law: None. R. Tan: None. V. Ramadoss: None. B. Tan: None. C. Sia: None. C. Khoo: None. P. Eng: None. Introduction: Women with gestational diabetes mellitus (GDM) are at increased risk of cardiovascular disea…
View article: Inpatient‐Onset Versus Outpatient‐Onset ST‐Segment–Elevation Myocardial Infarction in Patients With Percutaneous Coronary Intervention: A National Registry Study
Inpatient‐Onset Versus Outpatient‐Onset ST‐Segment–Elevation Myocardial Infarction in Patients With Percutaneous Coronary Intervention: A National Registry Study Open
Background Compared with patients who develop ST‐segment–elevation myocardial infarction (STEMI) outside the hospital and present at the emergency department (outpatient‐onset), patients with inpatient‐onset STEMI may paradoxically experie…
View article: Extracranial–intracranial bypass for symptomatic intracranial arterial occlusion: a meta-analysis of individual patient data
Extracranial–intracranial bypass for symptomatic intracranial arterial occlusion: a meta-analysis of individual patient data Open
Patients with symptomatic atherosclerotic internal carotid artery (ICA) or middle cerebral artery (MCA) occlusions face a high risk of recurrent ischaemic stroke despite best medical therapy. Previous trials of extracranial–intracranial (E…
View article: Cerebral Small‐Vessel Disease Markers on Magnetic Resonance Imaging as Predictors of Recurrent Vascular Events and Death in Ischemic Stroke: A Systematic Review and Meta‐Analysis
Cerebral Small‐Vessel Disease Markers on Magnetic Resonance Imaging as Predictors of Recurrent Vascular Events and Death in Ischemic Stroke: A Systematic Review and Meta‐Analysis Open
Background Cerebral small‐vessel disease encompasses a spectrum of magnetic resonance imaging features reflecting microvascular pathology in ischemic stroke. Among these, white matter hyperintensities (WMHs) and cerebral microbleeds (CMBs)…
View article: Sarcopenia and sarcopenic obesity in cardiovascular disease: a comprehensive review
Sarcopenia and sarcopenic obesity in cardiovascular disease: a comprehensive review Open
Sarcopenia is the loss of muscle strength, mass and function. It is often exacerbated by chronic comorbidities such as cardiovascular diseases (CVDs). There is a bidirectional relationship between sarcopenia and CVD. Sarcopenia can lead to…
View article: Personalized 4D Whole Heart Geometry Reconstruction from Cine MRI for Cardiac Digital Twins
Personalized 4D Whole Heart Geometry Reconstruction from Cine MRI for Cardiac Digital Twins Open
Cardiac digital twins (CDTs) provide personalized in-silico cardiac representations and hold great potential for precision medicine in cardiology. However, whole-heart CDT models that simulate the full organ-scale electromechanics of all f…
View article: The Prognostic Implication of Left Atrial Strain Parameters with Conventional Left Atrial Parameters for the Prediction of Adverse Outcomes in Asian Patients with Hypertrophic Cardiomyopathy—An Echocardiographic Study
The Prognostic Implication of Left Atrial Strain Parameters with Conventional Left Atrial Parameters for the Prediction of Adverse Outcomes in Asian Patients with Hypertrophic Cardiomyopathy—An Echocardiographic Study Open
Background/Objectives: Left atrial function can be a tool for risk stratification for hypertrophic cardiomyopathy (HCM). Over the past decade, there has been growing interest in the application of strain analysis for earlier and more accur…
View article: Prognostic Value of the Global Left Ventricular Contractility Index in Patients with Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction
Prognostic Value of the Global Left Ventricular Contractility Index in Patients with Severe Mitral Regurgitation and Preserved Left Ventricular Ejection Fraction Open
Introduction: Assessment of left ventricular (LV) systolic function is important in valvular heart disease. The global LV contractility index, dσ*/dtmax, is load-independent and has been reported to be associated with clinical outcomes in …
View article: Relative Hyperglycemia and In-Hospital Bleeding Across Glycemic Status in Patients on High-Intensity Antithrombotic Therapy
Relative Hyperglycemia and In-Hospital Bleeding Across Glycemic Status in Patients on High-Intensity Antithrombotic Therapy Open
In this study, a high SHR was an independent risk factor for in-hospital major bleeding after PCI, particularly in patients with Pre-DM. Further clinical trials are needed to explore SHR-targeted therapies in Pre-DM.
View article: Longitudinal Outcomes of Left Ventricular Outflow Tract Obstruction in Aortic Stenosis Versus Hypertrophic Obstructive Cardiomyopathy
Longitudinal Outcomes of Left Ventricular Outflow Tract Obstruction in Aortic Stenosis Versus Hypertrophic Obstructive Cardiomyopathy Open
Background and Objectives: Aortic stenosis (AS) and hypertrophic obstructive cardiomyopathy (HOCM) are two disease entities that result in left ventricular outflow tract (LVOT) obstruction. We sought to evaluate the longitudinal outcomes o…
View article: The Heart-Brain Axis: Key Concepts in Neurocardiology
The Heart-Brain Axis: Key Concepts in Neurocardiology Open
The heart-brain axis involves complex interactions between the cardiovascular and nervous systems via a network of cortical and subcortical structures working with the autonomic nervous system and intracardiac nervous system. Heart-brain i…
View article: Stroke Risk in Head and Neck Cancer: A Meta‐analysis of Reconstructed Individual Patient Survival Data
Stroke Risk in Head and Neck Cancer: A Meta‐analysis of Reconstructed Individual Patient Survival Data Open
Objective Although previous studies suggest an increased stroke risk in head and neck cancer (HNC) survivors, the risk with various treatment modalities, including radiotherapy, is less certain. This study investigates stroke incidence and…
View article: Clinical and echocardiographic differences between rheumatic and degenerative mitral stenosis
Clinical and echocardiographic differences between rheumatic and degenerative mitral stenosis Open
Introduction: Degenerative mitral stenosis (DMS) is frequently cited as increasing in prevalence in the developed world, although comparatively little is known about DMS in comparison to rheumatic mitral stenosis (RMS). Method: A retrospec…
View article: Return to Work After Ischemic Stroke in Young Adults: A Multicenter Cohort Study, Systematic Review, and Meta‐Analysis
Return to Work After Ischemic Stroke in Young Adults: A Multicenter Cohort Study, Systematic Review, and Meta‐Analysis Open
Background Ischemic stroke incidence in young adults is increasing globally, with return to work (RTW) a key rehabilitation goal. We aimed to assess the overall proportions of and factors associated with RTW following young adult ischemic …
View article: Pathophysiological Links Between Myocardial Infarction and Anxiety Disorder, Major Depressive Disorder, Bipolar Disorder and Schizophrenia
Pathophysiological Links Between Myocardial Infarction and Anxiety Disorder, Major Depressive Disorder, Bipolar Disorder and Schizophrenia Open
There is increasing evidence demonstrating that psychiatric conditions elevate the risk of developing accelerated atherosclerosis and early-onset cardiovascular disease (CVD), including myocardial infarction (MI). Several mechanisms contri…