Explanipedia

277. A LONG NONCODING ERNA FORMS R-LOOPS TO SHAPE EMOTIONAL EXPERIENCE-INDUCED BEHAVIORAL ADAPTATION Open

Rose Marie Akiki, Rebecca G Cornbrooks, Kosuke Magami, Alain Greige, Kristen Snyder , et al. · 2025

Background Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experi…

POS0058 GENERATION OF iPSC-DERIVED CAR-NK, γδ CAR-T, AND αβ CAR-T CELLS WITH POTENT ACTIVITY FOR TREATMENT OF B CELL-MEDIATED AUTOIMMUNE DISEASES Open

Joachim Kurtz, Daniel J. Perry, Dar Heinze, Liam Campion, M I Mendonça , et al. · 2025

Universal protection of allogeneic T-cell therapies from natural killer cells via CD300a agonism Open

Shuqi Zhang, Faith Thomas, Justin Fang, Kathryn Austgen, Chad A. Cowan , et al. · 2024

Immunogenicity limits the persistence of off-the-shelf allogeneic cell therapies and transplants. Although ablation of HLA removes most T cell and humoral alloreactivity, no solution has enabled universal protection against the resulting n…

Universal protection of allogeneic cell therapies from natural killer cells via CD300a agonism Open

Shuqi Zhang, Faith Thomas, Justin Fang, Kathryn Austgen, Chad A. Cowan , et al. · 2024

Immunogenicity limits the persistence of off-the-shelf, allogeneic cell therapies and transplants. While ablation of human leukocyte antigen (HLA) removes most T cell and humoral alloreactivity, no solution has enabled universal protection…

Chromatin regulator SMARCAL1 modulates cellular lipid metabolism Open

Taylor Hanta Nagai, Chrissy Hartigan, Taiji Mizoguchi, Haojie Yu, Amy Deik , et al. · 2023

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss Open

Hsiao‐Jou Cortina Chen, Andrian Yang, Simone Mazzaferro, Iman Mali, Olivier Cahn , et al. · 2023

Obesity substantially increases the risk of type 2 diabetes, cardiovascular disease, and other diseases, making it a leading preventable cause of death in developed countries. It has a strong genetic basis, with obesity-associated genetic …

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis Open

Marlies P. Rossmann, Karen Hoi, Victoria Chan, Brian J. Abraham, Song Yang , et al. · 2021

Metabolic pathway regulates cell fate Lineage-specific regulators direct cell fate decisions, but the precise mechanisms are not well known. Using an in vivo chemical suppressor screen of a bloodless zebrafish mutant, Rossmann et al. show …

More Bang for Your Buck: “Off-The-Shelf” Solutions for Cell Replacement Therapy Open

Torsten Meißner, Chad A. Cowan · 2020

The immune barrier to transplantation has widely been recognized as the ultimate hurdle to the translation of stem cell-based therapies. In particular the polymorphic nature of the human leucocyte antigens (HLA) poses an imminent barrier t…

Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells Open

Filip Roudnicky, Jitao David Zhang, Bo Kyoung Kim, Nikhil J. Pandya, Yanjun Lan , et al. · 2020

Significance Blood vessels in the central nervous system possess unique barrier properties that prevent infiltration of foreign substances and allow for precise delivery of ions, molecules, and immune cells into neural networks. Barrier br…

Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants Open

Siwei Zhang, Hanwen Zhang, Yifan Zhou, Min Qiao, Siming Zhao , et al. · 2020

Effects of allele-specific open chromatin Genetic variants in noncoding regions of the genome may underlie the development of disease. However, we are just beginning to tease apart the function of such variants associated with neuropsychia…

A coagulation defect arising from heterozygous premature termination of tissue factor Open

Sol Schulman, Emale El-Darzi, Mary H.C. Florido, Max Friesen, Glenn Merrill‐Skoloff , et al. · 2020

Tissue factor (TF) is the primary initiator of blood coagulation in vivo and the only blood coagulation factor for which a human genetic defect has not been described. As there are no routine clinical assays that capture the contribution o…

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis Open

Takafumi Toyohara, Filip Roudnicky, Mary H.C. Florido, Toshiaki Nakano, Haojie Yu , et al. · 2020

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis Open

Takafumi Toyohara, Filip Roudnicky, Mary H.C. Florido, Toshiaki Nakano, Haojie Yu , et al. · 2020

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program Open

Kanika Kanchan, Kruthika Iyer, Lisa R. Yanek, Ivan Carcamo‐Orive, Margaret A. Taub , et al. · 2020

Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes Open

Max Friesen, Curtis R. Warren, Haojie Yu, Takafumi Toyohara, Qiurong Ding , et al. · 2020

We previously discovered in mouse adipocytes an lncRNA (the homolog of human LINC00116) regulating adipogenesis that contains a highly conserved coding region. Here, we show human protein expression of a peptide within LINC00116, and demon…

Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance Open

Filip Roudnicky, Bo Kyoung Kim, Yanjun Lan, Roland Schmucki, Verena Küppers , et al. · 2020

Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes<i>in vitro</i> Open

Benjamin D. Pope, Curtis R. Warren, Madeleine O. Dahl, Christina V. Pizza, Douglas E. Henze , et al. · 2020

Micropatterned adipocytes are grown to adult cell sizesin vitroon a nanofiber network.

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype Open

Filip Roudnicky, Yanjun Lan, Max Friesen, Gregor Dernick, Jitao David Zhang , et al. · 2019

The kinase AKT2 (PKB) is an important mediator of insulin signaling, for which loss-of-function knockout (KO) mutants lead to early onset diabetes mellitus, and dominant active mutations lead to early development of obesity and endothelial…

Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes Open

Zhifen Chen, Haojie Yu, Xu Shi, Curtis R. Warren, Luca A. Lotta , et al. · 2019

Rationale: Genome-wide association studies have identified genetic loci associated with insulin resistance (IR) but pinpointing the causal genes of a risk locus has been challenging. Objective: To identify candidate causal genes for IR, we…

Allele-specific open chromatin in human iPSC neurons elucidates functional non-coding disease variants Open

Siwei Zhang, Hanwen Zhang, Min Qiao, Yifan Zhou, Siming Zhao , et al. · 2019

Functional interpretation of noncoding disease variants, which likely regulate gene expression, has been challenging. Chromatin accessibility strongly influences gene expression during neurodevelopment; however, to what extent genetic vari…

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis Open

Haojie Yu, Antoine Rimbert, Alice Palmer, Takafumi Toyohara, Yulei Xia , et al. · 2019

Generation of hypoimmunogenic human pluripotent stem cells Open

Xiao Han, Mengning Wang, Songwei Duan, Paul J. Franco, Jennifer Hyoje-Ryu Kenty , et al. · 2019

Significance To enable cell therapy on a broader scale, the development of universal donor stem cell products that can be administered to multiple patients in need has been proposed, yet a strategy controlling both adaptive and innate immu…

A DEDICATION THAT DRIVES THE GROWTH Open

Mariia Khilkovskaia, Michael Eisenberg, Snehil Tiwari, Alexandre S K Miguel, Chad A. Cowan · 2019

By implementing a better solution for shipment tracking, Michael wanted to facilitate better overall delivery service between WDS and its customers. The hardest question was that he did not know where to start. The quick solution of implem…

An hPSC-Derived Tissue-Resident Macrophage Model Reveals Differential Responses of Macrophages to ZIKV and DENV Infection Open

Jianshe Lang, Yichen Cheng, Alyssa J. Rolfe, Christy Hammack, Daniel L. Vera , et al. · 2018

Zika virus (ZIKV) and dengue virus (DENV) are two closely related flaviviruses that lead to different clinical outcomes. The mechanism for the distinct pathogenesis of ZIKV and DENV is poorly understood. Here, we investigate ZIKV and DENV …

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells Open

Jon S. Odorico, James F. Markmann, Douglas A. Melton, Julia Greenstein, Albert Hwa , et al. · 2018

Beta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care …

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol Open

Yuxin Xu, Valeska Redon, Haojie Yu, William Querbes, James P. Pirruccello , et al. · 2017

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci Open

Marc P. Forrest, Hanwen Zhang, Winton Moy, Heather McGowan, Catherine Leites , et al. · 2017

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease Open

Max Friesen, Raymond Camahort, Youn‐Kyoung Lee, Fang Xia, Robert E. Gerszten , et al. · 2017

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease Open

Curtis R. Warren, John O’Sullivan, Max Friesen, Caroline E. Becker, Xiaoling Zhang , et al. · 2017

The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics Open

Curtis R. Warren, Cashell E. Jaquish, Chad A. Cowan · 2017

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