Chad A. LaGrange
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View article: Urology Resident Associate: A Promising Alternative for the Unmatched Urology Applicant
Urology Resident Associate: A Promising Alternative for the Unmatched Urology Applicant Open
View article: Novel EC914 Targeting the LIFR/DDX21/Fibrillarin Axis Is a Potential Therapeutic Strategy To Overcome Adaptive Chemo-Persistence in Prostate Cancer
Novel EC914 Targeting the LIFR/DDX21/Fibrillarin Axis Is a Potential Therapeutic Strategy To Overcome Adaptive Chemo-Persistence in Prostate Cancer Open
View article: Supplementary Figure 1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S1. (A) Representative images of triple IHC staining of Integrin αvβ3 (green), Gal-3 (red), and E-cadherin (brown) in normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ3 ar…
View article: Movie S3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Movie S3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
PC-3 cell treated with water, stained for Integrin αv (red), Gal-3 (green), EEA1 (magenta). Areas of 3-color colocalization are highlighted with white. Surfaces were reconstructed by Imaris.
View article: Supplementary Figure 7 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 7 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S7. (A, B) Alcohol dehydrogenase (ADH1A) and Aldehyde dehydrogenase (ALDH2) W-B of the lysate of PC-3 (A) and DU145 (B) cells. Asterisks indicate the bands corresponding to the appropriate proteins.
View article: Supplementary Figure 8 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 8 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S8. AST (A) and ALT (B) serum activity from the indicated mice. ALT and AST activity were examined using the ALT Assay Kit (Abcam, ab241035) and the AST Assay Kit (Abcam, ab105135), respectively, per the manufacturer's protocol. Kru…
View article: Movie S4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Movie S4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
PC-3 cell treated with HCQ, stained for Integrin αv (red), Gal-3 (green), EEA1 (magenta). Areas of 3-color colocalization are highlighted with white. Surfaces were reconstructed by Imaris.
View article: Supplementary Figure 3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S3. (A) Representative images of triple IHC staining of Integrin αvβ6 (green), Gal-3 (brown), and Na+/K+-ATPase (red) in normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ6…
View article: Supplementary Figure 4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S4. (A) Representative images of Golgi in DU145 cells treated with 60 µM HCQ for 72 h and stained by GM130 (green); bars, 20 µm. (B) Quantification of Golgi spots per cell in samples from A. Unpaired t test; **p<0.01, mean ± SD; n r…
View article: Supplementary Figure 5 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 5 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S5. (A, B) Representative EM images of PC-3 (A) and DU145 (B) cells. Note phagophore nucleation from Golgi (arrowheads) and autophagosomes localizing close to the Golgi (arrow). Orange boxes indicate the areas magnified at the right…
View article: Supplementary Table 2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Table 2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Table 2. Combinations of siRNAs and shRNAs used for knockdown experiments.
View article: Supplementary Table 2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Table 2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Table 2. Combinations of siRNAs and shRNAs used for knockdown experiments.
View article: Supplementary Figure 10 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 10 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S10. (A) Evaluation of MGAT5-mediated Integrin αv glycosylation in the orthotopic tumor samples. Tissue samples were co-stained with Integrin αv (green) and Cy3 labeled PHA-L lectin (red). Representative Z-stack images were collecte…
View article: Supplementary Movies Description from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Movies Description from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplemental Movie 1 PC-3 cell treated with water, stained for Golgi (GRASP65, green) and MGAT3 (red). Surfaces were reconstructed by Imaris. Supplemental Movie 2 PC-3 cell treated with HCQ, stained for Golgi (GRASP65, green) and MGAT3 (re…
View article: Supplementary Movies Description from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Movies Description from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplemental Movie 1 PC-3 cell treated with water, stained for Golgi (GRASP65, green) and MGAT3 (red). Surfaces were reconstructed by Imaris. Supplemental Movie 2 PC-3 cell treated with HCQ, stained for Golgi (GRASP65, green) and MGAT3 (re…
View article: Data from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Data from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Prostate cancer (PCa) progression to the lethal metastatic castration-resistant phenotype (mCRPC) is driven by αv integrins and is associated with Golgi disorganization and activation of the ATF6 branch of unfolded protein response (UPR). …
View article: Supplementary Figure 6 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 6 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S6. (A) Immunostaining of Gal-3 (green) and Na+/K+-ATPase (red) in control and HCQ-treated PC-3 cells; bars, 20 µm. (B) Quantification of Gal-3 integrated intensity at PM in cells from A. Mann Whitney test; *p<0.05, mean ± SD; n ind…
View article: Movie S3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Movie S3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
PC-3 cell treated with water, stained for Integrin αv (red), Gal-3 (green), EEA1 (magenta). Areas of 3-color colocalization are highlighted with white. Surfaces were reconstructed by Imaris.
View article: Supplementary Figure 3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 3 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S3. (A) Representative images of triple IHC staining of Integrin αvβ6 (green), Gal-3 (brown), and Na+/K+-ATPase (red) in normal prostate and tumor tissues from PCa patients with different grades. Deconvoluted images of Integrin αvβ6…
View article: Supplementary Table 4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Table 4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Table 4. The Chi-squared and Fisher’s Exact tests of metastases in the group of mice with orthotopic tumor.
View article: Supplementary Methods and Materials from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Methods and Materials from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Methods and Materials
View article: Supplementary Figure 8 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 8 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S8. AST (A) and ALT (B) serum activity from the indicated mice. ALT and AST activity were examined using the ALT Assay Kit (Abcam, ab241035) and the AST Assay Kit (Abcam, ab105135), respectively, per the manufacturer's protocol. Kru…
View article: Supplementary Figure 9 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Figure 9 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Figure S9. (A) Left Panels: representative images of triple IHC staining of Na+/K+-ATPase (green), Integrin αv (red), and Gal-3 (brown) in the orthotopic tumor samples from the indicated group of mice; bars, 100 µm. Middle panel: IF of Gol…
View article: Movie S2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Movie S2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
PC-3 cell treated with HCQ, stained for Golgi (GRASP65, green) and MGAT3 (red). Surfaces were reconstructed by Imaris.
View article: Movie S2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Movie S2 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
PC-3 cell treated with HCQ, stained for Golgi (GRASP65, green) and MGAT3 (red). Surfaces were reconstructed by Imaris.
View article: Movie S1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Movie S1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
PC-3 cell treated with water, stained for Golgi (GRASP65, green) and MGAT3 (red). Surfaces were reconstructed by Imaris.
View article: Supplementary Methods and Materials from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Methods and Materials from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Methods and Materials
View article: Supplementary Table 1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Table 1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Table 1. Combinations of Abs used for IHC experiments.
View article: Supplementary Table 4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Table 4 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Table 4. The Chi-squared and Fisher’s Exact tests of metastases in the group of mice with orthotopic tumor.
View article: Supplementary Table 1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression
Supplementary Table 1 from Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression Open
Supplementary Table 1. Combinations of Abs used for IHC experiments.