Chad S. Hunter
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View article: Type 1 diabetes pathogenesis: an omics-based investigation using Non-Obese Diabetic (NOD) mice 3624
Type 1 diabetes pathogenesis: an omics-based investigation using Non-Obese Diabetic (NOD) mice 3624 Open
Description Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β cells. Despite significant advances in understanding T1D pathogenesis, the immunological mechanisms underlying β …
View article: SUN-546 ISL1 and LDB1 Transcriptional Complex Regulators of Pancreatic Islet Alpha-Cell Function
SUN-546 ISL1 and LDB1 Transcriptional Complex Regulators of Pancreatic Islet Alpha-Cell Function Open
Disclosure: I. Deeba: None. S. Poole: None. Y. Liu: None. T. Mitchell: None. C. Hunter: None. Diabetes was traditionally considered a dysglycemia centered on the insulin-secreting β-cell but is now recognized to also involve significant co…
View article: High-throughput investigation of macromolecular interactions for drug development using spectral shift technology
High-throughput investigation of macromolecular interactions for drug development using spectral shift technology Open
This review focuses on spectral shift analysis as a tool to study macromolecular interactions and describes its current place among the available biophysical methods. NanoTemper’s Dianthus platform facilitates a plate-based, microfluidics-…
View article: The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-cell Identity
The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-cell Identity Open
Diabetes is characterized by a loss of functional β-cell mass, therefore identifying factors involved in establishing and preserving β-cells is critical to combat rising diabetes incidence. While transcription factors are crucial β-cell re…
View article: The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-cell Identity
The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-cell Identity Open
Diabetes is characterized by a loss of functional β-cell mass, therefore identifying factors involved in establishing and preserving β-cells is critical to combat rising diabetes incidence. While transcription factors are crucial β-cell re…
View article: The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-Cell Identity
The Islet-1 Interaction Partner Rnf20 Regulates Glucose Homeostasis and Pancreatic β-Cell Identity Open
Diabetes is characterized by a loss of functional β-cell mass; therefore, identifying factors involved in establishing and preserving β-cells is critical to combat rising diabetes incidence. While transcription factors are crucial β-cell r…
View article: Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis
Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis Open
Summary The transition from proliferative to functionally mature β-cells is a critical developmental process, yet the molecular mechanisms that coordinate this shift remain poorly understood. Here, we identify Tomosyn-2 as a key regulator …
View article: 12527 Determining The Impact Of Dampened Oxidative Stress On Islet Function And Gene Expression During Diabetes Onset In NOD Mice
12527 Determining The Impact Of Dampened Oxidative Stress On Islet Function And Gene Expression During Diabetes Onset In NOD Mice Open
Disclosure: K.V. Coutinho: None. H. Shinde: None. J. Feduska: None. K. Burnette: None. S.O. Poole: None. H.M. Tse: None. C.S. Hunter: None. Type 1 diabetes (T1D) arises from autoimmune destruction of insulin-producing pancreatic β-cells. R…
View article: 9366 The Rnf20 Histone Modifier Is A Crucial Mediator Of Pancreatic Beta Cell Identity And Function
9366 The Rnf20 Histone Modifier Is A Crucial Mediator Of Pancreatic Beta Cell Identity And Function Open
Disclosure: T.H. Pierre: None. Y. Liu: None. M.M. Bethea: None. K. Coutinho: None. C. Hunter: None. Diabetes is characterized by the loss of pancreatic β-cell mass. As diabetes incidence continues to elevate, it is critical that we develop…
View article: 12439 Investigating The Regulation Of Islet Alpha-cell Function Mediated By The ISL1 And LDB1 Transcriptional Complex
12439 Investigating The Regulation Of Islet Alpha-cell Function Mediated By The ISL1 And LDB1 Transcriptional Complex Open
Disclosure: I. Deeba: None. S. Poole: None. Y. Liu: None. C. Hunter: None. Glucose homeostasis is maintained by the action of insulin-secreting β-cells and glucagon-producing α-cells in the pancreatic islet. Diabetes, traditionally conside…
View article: ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression
ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression Open
The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that ST6 β-galactoside α2,6 sialyltransferase 1 (ST6GAL1), which adds α2,6-linked si…
View article: Powertrain Performance and Total Cost of Ownership Analysis for Class 8 Yard Tractors and Refuse Trucks
Powertrain Performance and Total Cost of Ownership Analysis for Class 8 Yard Tractors and Refuse Trucks Open
Advanced powertrain technologies, specifically fuel cell electric powertrains, have gained attention as viable alternatives for medium- and heavy-duty (M/HD) vehicles. However, it is unclear how these alternative powertrain vehicles stack …
View article: RF04 | PSUN133 Assessment of the Rnf20 Histone Modifier in Regulating Pancreatic Beta-Cell Identity and Function
RF04 | PSUN133 Assessment of the Rnf20 Histone Modifier in Regulating Pancreatic Beta-Cell Identity and Function Open
Type 1 and Type 2 Diabetes are characterized by a loss of functional pancreatic islet β-cells. With the prevalence of diabetes increasing worldwide, a complete understanding of the gene regulatory mechanisms governing the development and f…
View article: The Ldb1 transcriptional co‐regulator is required for establishment and maintenance of the pancreatic endocrine lineage
The Ldb1 transcriptional co‐regulator is required for establishment and maintenance of the pancreatic endocrine lineage Open
Pancreatic islet cell development is regulated by transcription factors (TFs) that mediate embryonic progenitor differentiation toward mature endocrine cells. Prior studies from our lab and others showed that the islet‐enriched TF, Islet‐1…
View article: ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression
ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression Open
The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that the ST6GAL1 sialyltransferase, which adds α2,6-linked sialic acids to N -glycos…
View article: Islet transplantation into brown adipose tissue can delay immune rejection
Islet transplantation into brown adipose tissue can delay immune rejection Open
Type 1 diabetes is an autoimmune disease characterized by insulin-producing β cell destruction. Although islet transplantation restores euglycemia and improves patient outcomes, an ideal transplant site remains elusive. Brown adipose tissu…
View article: LDB1-mediated transcriptional complexes are sensitive to islet stress
LDB1-mediated transcriptional complexes are sensitive to islet stress Open
Excess nutrients and proinflammatory cytokines impart stresses on pancreatic islet β-cells that, if unchecked, can lead to cellular dysfunction and/or death. Among these stress-induced effects is loss of key β-cell transcriptional regulato…
View article: Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis
Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis Open
Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to insulin insufficiency and hyperglycemia, with patients eventua…
View article: The SSBP3 Co-Regulator Is a Novel Driver of Islet Cell Structure and Function
The SSBP3 Co-Regulator Is a Novel Driver of Islet Cell Structure and Function Open
The activities of transcriptional complexes drive the proper development and function of insulin producing beta-cells, ultimately required for the regulation of glucose homeostasis. Our prior work helped to establish that the LIM-homeodoma…
View article: Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes
Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes Open
Glucagon regulates glucose and lipid metabolism and promotes weight loss. Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully eluc…
View article: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression
Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression Open
Glucagon (GCG) is an essential regulator of glucose and lipid metabolism that also promotes weight loss. We have shown that glucagon-receptor (GCGR) signaling increases fatty acid oxidation (FAOx) in primary hepatocytes and reduces liver t…
View article: LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function
LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function Open
Diabetes is characterized by a loss of β-cell mass, and a greater understanding of the transcriptional mechanisms governing β-cell function is required for future therapies. Previously, we reported that a complex of the Islet-1 (Isl1) tran…
View article: OR28-2 The Ldb1 Transcriptional Co-regulator Is Required for Establishment, Development, and Survival of the Pancreatic Endocrine Lineage
OR28-2 The Ldb1 Transcriptional Co-regulator Is Required for Establishment, Development, and Survival of the Pancreatic Endocrine Lineage Open
Pancreatic islets are comprised of hormone-secreting cell types that are vital regulators of glucose homeostasis. Specifically, the pancreatic β-cell is indispensable for glucose metabolism and its dysfunction is central to diabetes mellit…
View article: Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets
Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets Open
Pancreatic β-cells undergo profound hyperplasia during pregnancy to maintain maternal euglycemia. Failure to reprogram β-cells into a more replicative state has been found to underlie susceptibility to gestational diabetes mellitus (GDM). …
View article: The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis
The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis Open
The LIM-homeodomain (LIM-HD) transcription factor Islet-1 (Isl1) interacts with the LIM domain-binding protein 1 (Ldb1) coregulator to control expression of key pancreatic β-cell genes. However, Ldb1 also has Isl1-independent effects, supp…
View article: Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes
Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes Open
The two main types of diabetes mellitus have distinct etiologies, yet a similar outcome: loss of islet β-cell function that is solely responsible for the secretion of the insulin hormone to reduce elevated plasma glucose toward euglycemic …