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View article: Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 Open
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins.…
View article: Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2
Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2 Open
Polycystin-2 (PC2) is a transient receptor potential (TRP) channel present in ciliary membranes of the kidney. PC2 shares a transmembrane fold with other TRP channels, in addition to an extracellular domain found in TRPP and TRPML channels…
View article: Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2 (PC2)
Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2 (PC2) Open
Polycystin-2 (PC2) is a member of the TRPP subfamily of TRP channels and is present in ciliary membranes of the kidney. PC2 can be either homo-tetrameric, or heterotetrameric with PC1. PC2 shares a common transmembrane fold with other TRP …
View article: Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs
Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs Open
The metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptors (GPCRs) that modulate synaptic activity and plasticity throughout the mammalian brain. Signal transduction is initiated by glutamate binding to the venus f…
View article: Porin self-association enables cell-to-cell contact in <i>Providencia stuartii</i> floating communities
Porin self-association enables cell-to-cell contact in <i>Providencia stuartii</i> floating communities Open
Significance We report that porins, the main gateway for hydrophilic nutrients and ions into bacterial cells, assemble face-to-face in crystals, yielding dimers of trimers (DOTs). Further investigation suggests that DOTs could support cell…
View article: Providencia stuartii form biofilms and floating communities of cells that display high resistance to environmental insults
Providencia stuartii form biofilms and floating communities of cells that display high resistance to environmental insults Open
Biofilms are organized communities of bacterial cells that are responsible for the majority of human chronic bacterial infections. Providencia stuartii is a Gram-negative biofilm-forming bacterium involved in high incidence of urinary trac…