Chak Shun Yu
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View article: Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia
Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia Open
The mitochondrial membrane potential (ΔΨ m ) drives oxidative phosphorylation and alterations contribute to cardiac pathologies, but real-time assessment of ΔΨ m has not been possible. Here we describe noninvasive measurements using mitoch…
View article: Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke
Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke Open
Aims Ischemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue, enhancing patient outcome, compared to recombinant tissue plasminogen activator (rtPA) alone.…
View article: An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i>
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i> Open
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses 1–6 , but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this question using a multi-omic approac…
View article: Mitochondrial metabolism is dynamically and reversibly modulated by cytosolic Na elevation in the heart
Mitochondrial metabolism is dynamically and reversibly modulated by cytosolic Na elevation in the heart Open
View article: Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart
Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart Open