Amit Kumar Chakraborty
YOU?
Author Swipe
View article: Shortest fixed-width confidence intervals for a bounded parameter: The Push algorithm
Shortest fixed-width confidence intervals for a bounded parameter: The Push algorithm Open
We present a method for computing optimal fixed-width confidence intervals for a single, bounded parameter, extending a method for the binomial due to Asparaouhov and Lorden, who called it the Push algorithm. The method produces the shorte…
View article: Integrative analysis identifies FBXO5 as a critical mediator of CRPC progression and bone metastatic potential
Integrative analysis identifies FBXO5 as a critical mediator of CRPC progression and bone metastatic potential Open
Taken together, our findings establish FBXO5 as a critical mediator of CRPC progression and bone metastatic potential, underscoring its importance as a promising therapeutic target for this aggressive disease.
View article: A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages
A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages Open
Osteoarthritis (OA) affects the entire knee joint, yet cross-tissue molecular interplay remains poorly understood. To address this, we constructed the first single-cell RNA sequencing atlas of knee OA, profiling articular cartilage, menisc…
View article: A Humanized Mouse Model of Oral Squamous Cell Carcinoma for Investigating Resistance to Anti-PD1 Immunotherapy
A Humanized Mouse Model of Oral Squamous Cell Carcinoma for Investigating Resistance to Anti-PD1 Immunotherapy Open
Immunotherapy has transformed cancer therapeutics; however, its impact on oral squamous cell carcinoma (OSCC) remains limited due to acquired resistance, including to Pembrolizumab. To better understand this challenge, we develop a humaniz…
View article: Unique TMJ-specific transcriptomic signature and its medial layer: Implications in osteoarthritis
Unique TMJ-specific transcriptomic signature and its medial layer: Implications in osteoarthritis Open
Objectives Osteoarthritis (OA) is a debilitating joint disease that affects millions of people worldwide, with the temporomandibular joint (TMJ) and knee joint being prominently affected. Despite its prevalence, TMJ-OA remains understudied…
View article: LOXL2 Deletion Triggers TMJ Osteoarthritis While Overexpression Protects Against NF-κβ-Induced Chondrocyte Apoptosis
LOXL2 Deletion Triggers TMJ Osteoarthritis While Overexpression Protects Against NF-κβ-Induced Chondrocyte Apoptosis Open
Temporomandibular joint osteoarthritis (TMJ-OA) affects a significant proportion of the population worldwide. However, there has been no substantial progress in the development of FDA-approved drugs for treatment due to a lack of understan…
View article: LOXL2 alleviates post-traumatic knee osteoarthritis and pain
LOXL2 alleviates post-traumatic knee osteoarthritis and pain Open
Cartilage has limited potential for self-regeneration, and damage can lead to structural, molecular, and functional aberrations, leading to osteoarthritis (OA). Traumatic knee injuries can also lead to cartilage degeneration and post-traum…
View article: Constructing a cross-tissue human knee single-cell atlas identified osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages
Constructing a cross-tissue human knee single-cell atlas identified osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages Open
Osteoarthritis (OA) affects the entire knee joint; however, cross-tissue molecular mechanisms are poorly understood due to a lack of comprehensive, integrated analysis. We constructed the first comprehensive single-cell RNA sequencing knee…
View article: Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression
Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression Open
View article: SEASONAL CATCH DYNAMICS AND TRENDS OF HILSA (TENUALOSA ILISHA) IN THE DOWNSTREAM REGION OF THE FARAKKA BARRAGE
SEASONAL CATCH DYNAMICS AND TRENDS OF HILSA (TENUALOSA ILISHA) IN THE DOWNSTREAM REGION OF THE FARAKKA BARRAGE Open
View article: Clinical data investigation identifies MARK3 as an oncogenic driver in castration-resistant prostate cancer
Clinical data investigation identifies MARK3 as an oncogenic driver in castration-resistant prostate cancer Open
View article: LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC
LSD1 inhibition corrects dysregulated MHC-I and dendritic cells activation through IFNγ-CXCL9-CXCR3 axis to promote antitumor immunity in HNSCC Open
Poor infiltration of CD8+ T cells and dysregulated MHC-I confer resistance to anticancer clinical therapies. This study aimed to elucidate the mechanisms of lysine-specific demethylase 1 (LSD1, encoded by KDM1A gene) in antitumor immunity …
View article: PREREQUISITE STEPS FOR DOMESTICATION OF HILSA (TENUALOSA ILISHA) IN FRESHWATER POND
PREREQUISITE STEPS FOR DOMESTICATION OF HILSA (TENUALOSA ILISHA) IN FRESHWATER POND Open
Hilsa (Tenualosa ilisha) is an important commercial fish species in the eastern region of Indian subcontinent, particularly Bangladesh and West Bengal, India.It contains a number of essential bio-chemicals, including n-3 polyunsaturated fa…
View article: Development of Dysprosium Particles Decorated Ambroxol Imprinted Polymer Sensor: A Sensitive Approach to Detect Carbide Treated Mango
Development of Dysprosium Particles Decorated Ambroxol Imprinted Polymer Sensor: A Sensitive Approach to Detect Carbide Treated Mango Open
View article: Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin
Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin Open
Marine sedimentation rate and bottom-water O2 concentration control organic carbon remineralization and sequestration across continental margins, but whether and how they shape microbiome architecture (the ultimate effector of all biogeoch…
View article: Mathematical Modeling and Analysis of the Dynamics of Chikungunya in Bangladesh
Mathematical Modeling and Analysis of the Dynamics of Chikungunya in Bangladesh Open
Chikungunya is one of the major public health problems in Bangladesh and the effect of the disease is more virulent over the country. In this paper, a compartmental mathematical model has been proposed that describes the transmission of ch…
View article: Mathematical Modelling and Analysis of Dengue Transmission in Bangladesh with Saturated Incidence Rate and Constant Treatment Function
Mathematical Modelling and Analysis of Dengue Transmission in Bangladesh with Saturated Incidence Rate and Constant Treatment Function Open
Dengue is one of the major health problems in Bangladesh and many people are died in recent years due to the severity of this disease. Therefore, in this paper, a SIRS model for the human and SI model for vector population with saturated i…
View article: Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin
Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin Open
Marine sedimentation rate and bottom-water O2 concentration control the remineralization/sequestration of organic carbon across continental margins; but whether/how they shape microbiome architecture (the ultimate effector of all biogeoche…
View article: Detection of classical swine fever virus E2 gene in cattle serum samples from cattle herds of Meghalaya
Detection of classical swine fever virus E2 gene in cattle serum samples from cattle herds of Meghalaya Open
View article: Seroprevalence of selected viral pathogens in pigs reared in organized farms of Meghalaya from 2014 to 16
Seroprevalence of selected viral pathogens in pigs reared in organized farms of Meghalaya from 2014 to 16 Open
The data from this study indicates ubiquitous prevalence of PCV2 antibodies in the farm animals along with the endemic presence of swine fever and emergence of PRRS in an organized farm. There are few reports regarding PCV2 infections/outb…
View article: Comparative enumeration of cytokine immune response in pbmc's of sows and piglets infected with porcine circovirus and classical swine fever virus
Comparative enumeration of cytokine immune response in pbmc's of sows and piglets infected with porcine circovirus and classical swine fever virus Open
Cytokines are important in mucosal immune response and regulation of metabolism and growth. Maternal cytokines form constructive blocks in the development of neonatal immune system. We have studied the expression of pro-inflammatory (Inter…
View article: An overview of physico-chemical mechanisms of biogas production by microbial communities: a step towards sustainable waste management
An overview of physico-chemical mechanisms of biogas production by microbial communities: a step towards sustainable waste management Open
View article: Complete Genome Sequence of Emerging Porcine Circovirus Types 2a and 2b from India
Complete Genome Sequence of Emerging Porcine Circovirus Types 2a and 2b from India Open
We report here the first characterized complete genome sequence of porcine circovirus types 2a and 2b from northeastern states of India. These isolates may serve as a potential reference for the Indian strains of porcine circovirus types 2…
View article: Complete Genome Sequence of Classical Swine Fever Virus Subgenogroup 2.1 from Assam, India
Complete Genome Sequence of Classical Swine Fever Virus Subgenogroup 2.1 from Assam, India Open
We report the complete genome sequence of a classical swine fever virus (genogroup 2.1), isolated from an outbreak in Assam, India. This particular isolate showed a high degree of genetic variation within the subgenogroup 2.1 and may serve…