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View article: p53-mediated regulation of electron transport chain and nucleotide synthesis during Newcastle disease virus infection
p53-mediated regulation of electron transport chain and nucleotide synthesis during Newcastle disease virus infection Open
Mitochondria and their electron transport chain (ETC) constitute the central machinery for cellular energy metabolism and biosynthetic regulation. Disruption of the ETC leads to reactive oxygen species (ROS) production and metabolic imbala…
View article: Newcastle disease virus acquires phosphatidylserine through the budding process to enhance infectivity
Newcastle disease virus acquires phosphatidylserine through the budding process to enhance infectivity Open
Newcastle disease, a highly contagious avian illness caused by the Newcastle disease virus (NDV), inflicts substantial economic losses upon the global poultry industry. While NDV is known to enter host cells via multiple pathways, critical…
View article: Virus infection and vesicle trafficking
Virus infection and vesicle trafficking Open
Vesicle trafficking mechanisms play indispensable roles throughout the viral replication cycle, though their stage-specific regulatory mechanisms during infection require further elucidation. Notably, the latest research reveals that diver…
View article: Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining
Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining Open
≈75% of emerging pathogens originating from wildlife. However, viral diversity within wildlife remains insufficiently explored. This work performs an extensive analysis of 57 536 publicly high‐throughput sequencing datasets from wild mamma…
View article: Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation
Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation Open
Newcastle disease virus (NDV), a widespread poultry pathogen, spreads efficiently via the respiratory tract. However, the precise mechanism governing its spreading infection remains unclear. This study reveals that NDV-induced tight juncti…
View article: The CRM1-dependent NES257−266 motif in the matrix protein: another factor influencing Newcastle disease virus propagation and virulence
The CRM1-dependent NES257−266 motif in the matrix protein: another factor influencing Newcastle disease virus propagation and virulence Open
As an important structural protein of Newcastle disease virus (NDV), the M protein plays a crucial role in the assembly and budding of the virus. In previous reports, we confirmed the existence of a classical nuclear export signal (NES) se…
View article: Pexophagy-driven redox imbalance promotes virus-induced ferroptosis
Pexophagy-driven redox imbalance promotes virus-induced ferroptosis Open
Peroxisomes are critical organelles that maintain cellular redox homeostasis. Many viruses induce oxidative stress and degrade peroxisomes, but the mechanisms and consequences remain unclear. In this study, we systematically investigate ho…
View article: HMGB1 as a Key Mediator in Malignant Mesothelioma and a Potential Target for Asbestos-Related Cancer Therapy
HMGB1 as a Key Mediator in Malignant Mesothelioma and a Potential Target for Asbestos-Related Cancer Therapy Open
Malignant mesothelioma (MM) is a highly aggressive cancer strongly associated with asbestos exposure, and accumulating evidence suggests that high mobility group box 1 (HMGB1) plays a central role in its pathogenesis. Our in vitro and in v…
View article: Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation
Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation Open
Coronavirus entry into host cells enables the virus to initiate its replication cycle efficiently while evading host immune response. Cell entry is intricately associated with pH levels in the cytoplasm or endosomes. In this study, we obse…
View article: Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling
Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling Open
This study identified key inflammation-related proteins and pathways that vary seasonally in SAR, offering insights into potential biomarkers and therapeutic targets for SAR management. Further studies are recommended to validate these fin…
View article: Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults
Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults Open
α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear. This study investigated the rela…
View article: Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis
Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis Open
The endoribonuclease (EndoU) nsp15 of coronaviruses plays a crucial role in evading host innate immune responses by reducing the abundance of viral double-stranded RNA (dsRNA). However, our understanding of its interactions with host cellu…
View article: Global burden of osteoarthritis among postmenopausal women in 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021
Global burden of osteoarthritis among postmenopausal women in 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 Open
Objectives Our study aimed to provide global burden and temporal trends in the incidence, prevalence, and disability-adjusted life-years (DALYs) of osteoarthritis (OA) among postmenopausal women from 1990 to 2021. Methods The study employe…
View article: UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models
UBA52 Mediates ribosomal DNA stability under hexavalent chromium exposure in occupational workers and cellular models Open
Hexavalent chromium [Cr(VI)] exposure poses substantial environmental and health risks, especially in occupational settings, where it has been linked to genomic instability. Our previous research demonstrated that Cr(VI) exposure could ind…
View article: La Sota-vectored recombinant vaccine with chimeric hemagglutinin-neuraminidase for enhanced protection against highly pathogenic pigeon paramyxovirus type 1
La Sota-vectored recombinant vaccine with chimeric hemagglutinin-neuraminidase for enhanced protection against highly pathogenic pigeon paramyxovirus type 1 Open
Pigeon Paramyxovirus Type 1 (PPMV-1), an antigenic and host variant of the Newcastle Disease Virus (NDV), can infect pigeons of all ages and cause severe economic losses in the poultry industry. The existing commercial vaccines are not cap…
View article: Advances in the type IX secretion system: an exploration focusing on Riemerella anatipestifer
Advances in the type IX secretion system: an exploration focusing on Riemerella anatipestifer Open
The type IX secretion system (T9SS) is specific to the Fibrobacteres-Chlorobi-Bacteroidetes superphylum, the members of which have many specialized features, including gliding motility and the transport of cargo proteins across the outer m…
View article: Onset and long-term duration of immunity provided by a single vaccination with recombinant a Marek’s disease virus with REV-LTR insertion
Onset and long-term duration of immunity provided by a single vaccination with recombinant a Marek’s disease virus with REV-LTR insertion Open
Marek’s Disease (MD), caused by Marek’s disease virus (MDV), is a highly contagious lymphoproliferative disease in poultry. Despite the fact that MD has been effectively controlled by vaccines, the virulence of field isolates of MDV has co…
View article: H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication
H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication Open
During infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a well-established phenomenon in previous research. The Golgi apparatus, situated downstream of the ER and crucial for protein trafficking, may be im…
View article: Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves
Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves Open
Parthanatos is distinct from caspase-dependent apoptosis in that it does not necessitate the activation of caspase cascades; Instead, it relies on the translocation of Apoptosis-inducing Factor (AIF) from the mitochondria to the nucleus, r…
View article: Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response
Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response Open
The hallmark of coronavirus infection lies in its ability to evade host immune defenses, a process intricately linked to the nuclear entry of transcription factors crucial for initiating the expression of antiviral genes. Central to this e…
View article: Identification and genomic characterization of a novel bisegmented coronavirus in the lesser panda
Identification and genomic characterization of a novel bisegmented coronavirus in the lesser panda Open
Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses and are renowned for their capacity to infect a diverse range of animals, including humans. In this study, we report the identification and characterization of a…
View article: Live Attenuated aTJ Vaccine Effectively Protects Pigeons Against Homologous PPMV-1 Challenge
Live Attenuated aTJ Vaccine Effectively Protects Pigeons Against Homologous PPMV-1 Challenge Open
Background: Pigeon paramyxovirus type 1 (PPMV-1) is a significant pathogen affecting pigeon populations globally. The commonly used La Sota vaccine provides limited protection due to antigenic divergence from circulating PPMV-1 strains. An…
View article: The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample
The role of serum α-Klotho levels in preventing hearing impairment among middle-aged and older adults: insights from a nationally representative sample Open
Background The Klotho gene is implicated in suppressing aging phenotypes and influencing age-related diseases. Previous studies have delved into its connection with different diseases, yet the association between Klotho and hearing loss ha…
View article: The Impact of Ambient Air Pollution on Allergic Rhinitis Symptoms: A Prospective Follow-Up Study
The Impact of Ambient Air Pollution on Allergic Rhinitis Symptoms: A Prospective Follow-Up Study Open
Air pollution has become a serious public health problem and there is evidence that air pollution affects the incidence of allergic rhinitis. To further investigate the effect of ambient air pollutants on the severity of allergic rhinitis …
View article: The effect of the nucleolar protein ZNF385A on the ribosomal DNA copy number variation in response to Cr(VI)-induced DNA damage
The effect of the nucleolar protein ZNF385A on the ribosomal DNA copy number variation in response to Cr(VI)-induced DNA damage Open
Hexavalent chromium [Cr(VI)] is a widely distributed carcinogen in industrial contexts and general environmental contexts. Emerging research highlights the central role of ribosomal DNA (rDNA) in DNA Damage Responses (DDRs). However, there…
View article: Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination
Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination Open
Vaccination is crucial for the prevention and mitigation of avian influenza infections in China. The inactivated H7N9 vaccine, when administered to poultry, significantly lowers the risk of infection among both poultry and humans, while al…