Chan Hum Park
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View article: Exploring Vaginal Microbiota–Tissue Resident Stem Cell Crosstalk:VCAM1-Mediated Enhancement of Regenerative Capacity
Exploring Vaginal Microbiota–Tissue Resident Stem Cell Crosstalk:VCAM1-Mediated Enhancement of Regenerative Capacity Open
The vaginal microbiota plays a critical role in regulating endometrial development, which is key for successful embryo implantation and pregnancy. However, the extent to which the vaginal microbiota contributes to various tissue regenerati…
View article: Precise Detection of Surgical Margin in Head and Neck Cancer Using Dual Near-Infrared Imaging of the Tumor and Tumor Microenvironment
Precise Detection of Surgical Margin in Head and Neck Cancer Using Dual Near-Infrared Imaging of the Tumor and Tumor Microenvironment Open
The precise determination of resection margins during head and neck cancer surgery remains an unmet clinical challenge, where balancing complete tumor removal with preservation of healthy tissue is critical. To address this, we developed a…
View article: Transcriptomic Changes in Human Tonsil-Derived Mesenchymal Stem Cells Across Culture Passages
Transcriptomic Changes in Human Tonsil-Derived Mesenchymal Stem Cells Across Culture Passages Open
Background/Objectives: Tonsil-derived mesenchymal stem cells (TMSCs) are in the limelight in regenerative medicine due to their high proliferation and differentiation potential. It is important to conduct studies to determine the optimal c…
View article: Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue Open
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining testicular characteristics and spermatogenesis. Conventional 2D and the recent 3D assay systems fai…
View article: Exploring Memory Function Beyond Immune Cells: ANGPTL4‐Mediated Memory Functions in Tissue Resident Stem Cells
Exploring Memory Function Beyond Immune Cells: ANGPTL4‐Mediated Memory Functions in Tissue Resident Stem Cells Open
Adapted immune cells are known to develop memory functions that increase resistance to subsequent infections after initial pathogen exposure, however, it is unclear whether non‐immune cells, like tissue‐resident stem cells, have similar me…
View article: Recycling and ecotoxicity of flax/PLA composites: Influence of seawater aging
Recycling and ecotoxicity of flax/PLA composites: Influence of seawater aging Open
Poly(lactic acid) is finding increasing applications as it is a bio-sourced compostable thermoplastic. Its properties can be improved by adding flax fibres, which are also compostable. The possibility to recycle the composite after service…
View article: Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration
Development of cell-laden multimodular Lego-like customizable endometrial tissue assembly for successful tissue regeneration Open
Background The endometrium, the inner lining of the uterine cavity, plays essential roles in embryo implantation and its subsequent development. Although some positive results were preliminarily archived, the regeneration of damaged endome…
View article: Three-Dimensional Digital Light-Processing Bioprinting Using Silk Fibroin-Based Bio-Ink: Recent Advancements in Biomedical Applications
Three-Dimensional Digital Light-Processing Bioprinting Using Silk Fibroin-Based Bio-Ink: Recent Advancements in Biomedical Applications Open
Three-dimensional (3D) bioprinting has been developed as a viable method for fabricating functional tissues and organs by precisely spatially arranging biomaterials, cells, and biochemical components in a layer-by-layer fashion. Among the …
View article: Fluidic integrated <scp>3D</scp> bioprinting system to sustain cell viability towards larynx fabrication
Fluidic integrated <span>3D</span> bioprinting system to sustain cell viability towards larynx fabrication Open
Herein, we report the first study to create a three‐dimensional (3D) bioprinted artificial larynx for whole‐laryngeal replacement. Our 3D bio‐printed larynx was generated using extrusion‐based 3D bioprinter with rabbit's chondrocyte‐laden …
View article: Human Embryonic Stem Cell-derived Cerebral Organoids for Treatment of Mild Traumatic Brain Injury in a Mouse Model
Human Embryonic Stem Cell-derived Cerebral Organoids for Treatment of Mild Traumatic Brain Injury in a Mouse Model Open
Objective: There are no effective treatments for relieving neuronal dysfunction after mild traumatic brain injury (TBI). Here, we evaluated therapeutic efficacy of human embryonic stem cell-derived cerebral organoids (hCOs) in a mild TBI m…
View article: A Case of Chondrosarcoma With Maffucci Syndrome Presenting Adult Onset Otitis Media With Effusion
A Case of Chondrosarcoma With Maffucci Syndrome Presenting Adult Onset Otitis Media With Effusion Open
Maffucci syndrome is a non-hereditary disease, in which benign cartilage tumor called enchondroma occurs throughout the body, causing various symptoms. In particular, when chondrosarcoma occurs in the skull base, various neurologic symptom…
View article: Silk Fibroin-Based Biomaterials for Hemostatic Applications
Silk Fibroin-Based Biomaterials for Hemostatic Applications Open
Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the r…
View article: Association Between Copeptin and Six-Month Neurologic Outcomes in Patients With Moderate Traumatic Brain Injury
Association Between Copeptin and Six-Month Neurologic Outcomes in Patients With Moderate Traumatic Brain Injury Open
Background Copeptin has been reported as a predictive biomarker for the prognosis after traumatic brain injury (TBI). However, most of them were in patients with severe TBI and limited value in predicting outcomes in patients with moderate…
View article: Fabrication and characterization of a myrrh hydrocolloid dressing for dermal wound healing
Fabrication and characterization of a myrrh hydrocolloid dressing for dermal wound healing Open
Common occurrence of dermal injuries has made wound dressing a critical component in wound healing. Hydrocolloid wound dressings have been developed as fanciful and effective wound dressing with ability for wound fluid control, adherence t…
View article: Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma
Treatment of Fungal-Infected Diabetic Wounds with Low Temperature Plasma Open
Diabetes mellitus renders patients susceptible to chronic wounds and various infections. Regarding the latter, fungal infections are of particular concern since, although they are the source of significant morbidity and mortality in immuno…
View article: The mature fruit of Lycium chinense Miller attenuates cisplatin-induced renal damage in mice via regulation of oxidant and antioxidant enzymes
The mature fruit of Lycium chinense Miller attenuates cisplatin-induced renal damage in mice via regulation of oxidant and antioxidant enzymes Open
The present study was conducted to examine whether Lycii Fructus, the mature fruit of Lycium chinense Miller (Solanaceae), is a functional food and has an ameliorative effect on a mouse model of cisplatin-induced acute renal failure. Cispl…
View article: Non‐invasive in vivo monitoring of transplanted stem cells in <scp>3D</scp>‐bioprinted constructs using near‐infrared fluorescent imaging
Non‐invasive in vivo monitoring of transplanted stem cells in <span>3D</span>‐bioprinted constructs using near‐infrared fluorescent imaging Open
Cell‐based tissue engineering strategies have been widely established. However, the contributions of the transplanted cells within the tissue‐engineered scaffolds to the process of tissue regeneration remain poorly understood. Near‐infrare…
View article: Cytocompatibility of Modified Silk Fibroin with Glycidyl Methacrylate for Tissue Engineering and Biomedical Applications
Cytocompatibility of Modified Silk Fibroin with Glycidyl Methacrylate for Tissue Engineering and Biomedical Applications Open
Hydrogel with chemical modification has been used for 3D printing in the biomedical field of cell and tissue-based regeneration because it provides a good cellular microenvironment and mechanical supportive ability. As a scaffold and a mat…
View article: 3D Printing and NIR Fluorescence Imaging Techniques for the Fabrication of Implants
3D Printing and NIR Fluorescence Imaging Techniques for the Fabrication of Implants Open
Three-dimensional (3D) printing technology holds great potential to fabricate complex constructs in the field of regenerative medicine. Researchers in the surgical fields have used 3D printing techniques and their associated biomaterials f…
View article: Rapidly photocurable silk fibroin sealant for clinical applications
Rapidly photocurable silk fibroin sealant for clinical applications Open
Sealants are useful as agents that can prevent the leakage of gas or nonclotting fluids from damaged tissues and of blood from the vascular system following injury or repair. Various formulations for sealants have been developed and applie…
View article: Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice
Seomae mugwort and jaceosidin attenuate osteoarthritic cartilage damage by blocking IκB degradation in mice Open
Seomae mugwort, a Korean native variety of Artemisia argyi , exhibits physiological effects against various diseases. However, its effects on osteoarthritis (OA) are unclear. In this study, a Seomae mugwort extract prevented cartilage dest…
View article: Increased the risk of depression in patients with chronic rhinosinusitis without polyp
Increased the risk of depression in patients with chronic rhinosinusitis without polyp Open
Previous studies have reported that chronic rhinosinusitis (CRS) is closely related to depression. The present study aims to elucidate the association between CRS without nasal polyp and depression using a national sample cohort. Using the…
View article: Recent Advances in Fluorescent Silk Fibroin
Recent Advances in Fluorescent Silk Fibroin Open
Silk is a natural macromolecular protein consisting of fibroin and sericin. Silk fibroin (SF), derived from Bombyx mori, is a representative fibrous protein that has been used mainly in fashion textiles and surgical sutures. Also, SF has b…
View article: An omentum-cultured 3D-printed artificial trachea: <i>in vivo</i> bioreactor
An omentum-cultured 3D-printed artificial trachea: <i>in vivo</i> bioreactor Open
The purpose of this study was to evaluate whether the prior implantation of a 3D-printed polycaprolactone (PCL) artificial trachea in the omentum is beneficial for revascularization of the scaffold and reduces associated complications in t…
View article: Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement
Fabrication of a Urea Biosensor for Real-Time Dynamic Fluid Measurement Open
In this study, a portable urea sensor that monitors the urea concentration in flow conditions was fabricated. We propose an electrochemical sensor that continually measures the urea concentration of samples flowing through it at a constant…