Explanipedia

Diagnostic Challenges, Prognostic Assessment, and Treatment Strategies in High-Grade Differentiated Thyroid Carcinoma Open

Chan Kwon Jung, Agnes Stephanie Harahap · 2025

Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance Open

Chan Kwon Jung, Chankyung Kim, Sora Jeon, Andrey Bychkov · 2025

Multi-institutional validation of AI models for classifying urothelial neoplasms in digital pathology Open

Jun Young Park, Jisup Kim, Young Jae Kim, Sung Hyun Kim, Chi Sung An , et al. · 2025

SERS‐AI‐LUA‐Driven Salivary Diagnosis of Head and Neck Cancer Using Graphene‐Assisted Plasmonic Nanocorals Open

Hyo Jeong Seo, Boyou Heo, Jun-Young Yang, Rowoon Park, Sung‐Gyu Park , et al. · 2025

The early detection of head and neck cancer (HNC) remains an important challenge owing to the lack of reliable noninvasive biomarkers. This study introduces a graphene‐assisted plasmonic nanocoral platform coupled with an artificial intell…

Smarter biopsy decisions in thyroid nodules via dual-modal photoacoustic and ultrasound imaging Open

Jhong Chan Ahn, Jaekyung Lee, Kwangsoon Kim, Ja Seong Bae, Chan Kwon Jung , et al. · 2025

Thyroid nodules are primarily diagnosed using ultrasound imaging (USI), but its low specificity leads to unnecessary fine-needle aspiration biopsies (FNABs). In particular, USI’s limited ability to differentiate follicular neoplasms from b…

Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer Open

L. Sylvia, Zubair Baloch, Chan Kwon Jung, Nicole A. Cipriani, Armando Gamboa‐Domínguez , et al. · 2025

The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and s…

2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma Open

Eun Kyung Lee, Min Joo Kim, Seung Heon Kang, Bon Seok Koo, Kyungsik Kim , et al. · 2025

The increasing detection of papillary thyroid microcarcinoma (PTMC) has raised concerns regarding overtreatment. For low-risk PTMC, either immediate surgery or active surveillance (AS) can be considered. To facilitate the implementation of…

The Initial Risk Stratification System for Differentiated Thyroid Cancer: Key Updates in the 2024 Korean Thyroid Association Guideline Open

Shinje Moon, Young Shin Song, Kyong Yeun Jung, Eun Kyung Lee, Jeongmin Lee , et al. · 2025

In 2024, the Korean Thyroid Association (KTA) introduced a revised Risk Stratification System (K-RSS) for differentiated thyroid cancer, building upon the modified RSS (M-RSS) proposed by the American Thyroid Association in 2015. The K-RSS…

The Evolution of Digital Pathology in Infrastructure, Artificial Intelligence and Clinical Impact Open

Chan Kwon Jung · 2025

2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma Open

Eun Kyung Lee, Min Joo Kim, Seung Heon Kang, Bon Seok Koo, Kyungsik Kim , et al. · 2025

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 5. Evaluation of Recurrence Risk Postoperatively and Initial Risk Stratification in Differentiated Thyroid Cancer 2024 Open

Eun Kyung Lee, Young Shin Song, Ho‐Cheol Kang, Sun Wook Kim, Dong Gyu Na , et al. · 2025

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 4. Pathological Diagnosis and Staging after Thyroidectomy 2024 Open

Su‐Jin Shin, Hee Young Na, Ho‐Cheol Kang, Sun Wook Kim, Dong Gyu Na , et al. · 2025

Supplementary Table S1 from Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer Open

Jeongmin Lee, Young Shin Shin, Jennifer Kwak, Hye Lim Park, Sohee Lee , et al. · 2025

Supplementary Table S1 presents the baseline characteristics of the study population (n = 230), including demographic data, surgical procedures, FNAC time points, lymph node dissection status, and key laboratory parameters such as serum Tg…

Data from Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer Open

Jeongmin Lee, Young Shin Shin, Jennifer Kwak, Hye Lim Park, Sohee Lee , et al. · 2025

Purpose:Traditional methods, fine-needle aspiration cytology (FNAC), and washout thyroglobulin (Tg) do not always provide sufficient accuracy for diagnosing lymph node (LN) metastasis in thyroid cancer. This study aimed to validate the dia…

Supplementary Table S2 from Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer Open

Jeongmin Lee, Young Shin Shin, Jennifer Kwak, Hye Lim Park, Sohee Lee , et al. · 2025

Supplementary Table S2 presents the results of a multivariate logistic regression analysis identifying factors associated with TERT mutation. Covariates include age, sex, serum Tg, Tg antibody, BRAF mutation, washout Tg, and washout CYFRA …

EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer Open

Chul‐Hwan Lee, Hanbyeol Kim, Do‐Gyun Kim, Su Min Ha, Junyoung Jang , et al. · 2025

Summary Dysregulation of Polycomb Repressive Complex 2 (PRC2) is established to contribute to cancer. Of its catalytic subunits, EZH1 and EZH2, EZH2 mutations in cancer have been extensively identified and studied, but the role of EZH1 in …

Tracing genomic instability in induced mesenchymal stromal cell manufacture: an integration-free transfection approach Open

Jong‐Mi Lee, C. Lee, Binna Seol, Chan Kwon Jung, Yonggoo Kim , et al. · 2025

Validation of Diagnostic Utility of Washout CYFRA 21-1 in Lymph Node Metastasis of Thyroid Cancer Open

Jeongmin Lee, Young Shin Shin, Jennifer Kwak, Hye Lim Park, Sohee Lee , et al. · 2025

Purpose: Traditional methods, fine-needle aspiration cytology (FNAC), and washout thyroglobulin (Tg) do not always provide sufficient accuracy for diagnosing lymph node (LN) metastasis in thyroid cancer. This study aimed to validate the di…

Establishment of iPSC-Derived MSCs Expressing hsa-miR-4662a-5p for Enhanced Immune Modulation in Graft-Versus-Host Disease (GVHD) Open

Susie Lee, Eung-Won Kim, Haeri Lee, Sun-Ung Lim, Chan Kwon Jung , et al. · 2025

The immune-modulatory effects of mesenchymal stromal cells (MSCs) are widely used to treat inflammatory disorders, with indoleamine 2,4-dioxygenase-1 (IDO-1) playing a pivotal role in suppressing stimulated T-cell proliferation. Taking tha…

Leveraging explainable AI and large-scale datasets for comprehensive classification of renal histologic types Open

Seung Wan Moon, Jisup Kim, Young‐Jae Kim, Sung Hyun Kim, Chi Sung An , et al. · 2025

Recently, as the number of cancer patients has increased, much research is being conducted for efficient treatment, including the use of artificial intelligence in genitourinary pathology. Recent research has focused largely on the classif…

Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia Open

Hee Young Na, Miyoko Higuchi, Shinya Satoh, Kaori Kameyama, Chan Kwon Jung , et al. · 2024

Background: This study was designed to compare diagnostic categories of thyroid fine needle aspiration cytology (FNAC) and incidence of thyroid tumors in the multi-institutional Asian series with a special focus on diagnostic category IV (…

Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes Open

Agnes Stephanie Harahap, Chan Kwon Jung · 2024

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, characterized by a range of subtypes that differ in their cytologic features, clinical behavior, and prognosis. Accurate cytologic evaluation of PTC using fine-needle…

Deep learning-based virtual staining, segmentation, and classification in label-free photoacoustic histology of human specimens Open

Chiho Yoon, Eunwoo Park, Sampa Misra, Jin Young Kim, Jin Woo Baik , et al. · 2024

In pathological diagnostics, histological images highlight the oncological features of excised specimens, but they require laborious and costly staining procedures. Despite recent innovations in label-free microscopy that simplify complex …

Leveraging Explainable AI and Large-Scale Datasets for Comprehensive Classification of Renal Histologic Types Open

Seung Wan Moon, Jisup Kim, Young‐Jae Kim, Sung Hyun Kim, Chi Sung An , et al. · 2024

Recently, as the number of cancer patients has increased, much research is being conducted for efficient treatment, including the use of artificial intelligence in renal pathology. Recent research has focused largely on the classification …

Educational exchange in thyroid core needle biopsy diagnosis: enhancing pathological interpretation through guideline integration and peer learning Open

Agnes Stephanie Harahap, Chan Kwon Jung · 2024

Background: While fine needle aspiration cytology (FNAC) plays an essential role in the screening of thyroid nodules, core needle biopsy (CNB) acts as an alternative method to address FNAC limitations. However, diagnosing thyroid CNB sampl…

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 4. Pathological Diagnosis and Staging after Thyroidectomy 2024 Open

Su‐Jin Shin, Hee Young Na, Ho‐Cheol Kang, Sun Wook Kim, Dong Gyu Na , et al. · 2024

Su-Jin Shin, Hee Young Na, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Young Joo Park, Young Shin Song, Eun Kyung Lee, Dong-Jun Lim, Yun Jae Chung, Chan Kwon Jung, Korean Thyroid Association Guideline Committee on the Managements of Thyroid …

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 2. Surgical Management of Thyroid Cancer 2024 Open

Yoon Young Cho, Cho Rok Lee, Ho‐Cheol Kang, Bon Seok Koo, Hyungju Kwon , et al. · 2024

Yoon Young Cho, Cho Rok Lee, Ho-Cheol Kang, Bon Seok Koo, Hyungju Kwon, Sun Wook Kim, Won Woong Kim, Jung-Han Kim, Dong Gyu Na, Young Joo Park, Kyorim Back, Young Shin Song, Seung Hoon Woo, Ho-Ryun Won, Chang Hwan Ryu, Jee Hee Yoon, Min Ky…

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 5. Evaluation of Recurrence Risk Postoperatively and Initial Risk Stratification in Differentiated Thyroid Cancer 2024 Open

Eun Kyung Lee, Young Shin Song, Ho‐Cheol Kang, Sun Wook Kim, Dong Gyu Na , et al. · 2024

Eun Kyung Lee, Young Shin Song, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Shin Je Moon, Dong-Jun Lim, Kyong Yeun Jung, Yun Jae Chung, Chan Kwon Jung, Young Joo Park, Korean Thyroid Association Guideline Committee on the Managements of Thyr…

Korean Thyroid Association Management Guidelines for Patients with Thyroid Nodules 2024 Open

Young Joo Park, Eun Kyung Lee, Young Shin Song, Su Hwan Kang, Bon Seok Koo , et al. · 2024

Young Joo Park, Eun Kyung Lee, Young Shin Song, Su Hwan Kang, Bon Seok Koo, Sun Wook Kim, Dong Gyu Na, Seung-Kuk Baek, So Won Oh, Min Kyoung Lee, Sang-Woo Lee, Young Ah Lee, Yong Sang Lee, Ji Ye Lee, Dong-Jun Lim, Leehi Joo, Yuh-Seog Jung,…

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Overview and Summary 2024 Open

Young Joo Park, Eun Kyung Lee, Young Shin Song, Bon Seok Koo, Hyungju Kwon , et al. · 2024

Young Joo Park, Eun Kyung Lee, Young Shin Song, Bon Seok Koo, Hyungju Kwon, Keunyoung Kim, Mijin Kim, Bo Hyun Kim, Won Gu Kim, Won Bae Kim, Won Woong Kim, Jung-Han Kim, Hee Kyung Kim, Hee Young Na, Shin Je Moon, Jung-Eun Moon, Sohyun Park,…

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