Yong Chan Lee
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View article: Comparing the Efficacy and Safety of Fexuprazan and Lansoprazole for the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Peptic Ulcer
Comparing the Efficacy and Safety of Fexuprazan and Lansoprazole for the Prevention of Nonsteroidal Anti-inflammatory Drug-Induced Peptic Ulcer Open
Given its non-inferiority to lansoprazole and similar safety profile, fexuprazan is a promising alternative for the prevention of NSAID-induced PUs (ClinicalTrials.gov identifier NCT04784910).
View article: Application of an organoid-based model to explore Helicobacter pylori–human gastric epithelium interaction in vitro
Application of an organoid-based model to explore Helicobacter pylori–human gastric epithelium interaction in vitro Open
Helicobacter pylori infection causes histopathologic changes in gastric epithelial cells, resulting in conditions such as gastritis, gastric ulcers, and ultimately, gastric cancer. To date, various experimental models, including cell lines…
View article: <div> A Study on the Problems Related to the Unified Approach Under Digital Tax and the Proposed Alternative Approach – by Comparing With Transfer Pricing Regulations</div>
A Study on the Problems Related to the Unified Approach Under Digital Tax and the Proposed Alternative Approach – by Comparing With Transfer Pricing Regulations Open
View article: <div> A Study on Transfer Pricing Aspects of Intangibles under LCITA (Law for the Coordination of International Tax Affairs)</div>
A Study on Transfer Pricing Aspects of Intangibles under LCITA (Law for the Coordination of International Tax Affairs) Open
View article: A Phase 2, Multi‐Center, Randomized, Double‐Blind, Parallel‐Group Trial to Evaluate the Efficacy and Safety of CKD‐495 in Patients With Acute and Chronic Gastritis
A Phase 2, Multi‐Center, Randomized, Double‐Blind, Parallel‐Group Trial to Evaluate the Efficacy and Safety of CKD‐495 in Patients With Acute and Chronic Gastritis Open
CKD‐495 is a newly developed drug extracted from Cinnamomum cassia Presl. This phase II study assessed the clinical benefits of CKD‐495 in the treatment of acute and chronic gastritis. This study randomly assigned 250 patients with endosco…
View article: Randomized Multicenter Study to Evaluate the Efficacy and Safety of Fexuprazan According to the Timing of Dosing in Patients With Erosive Esophagitis
Randomized Multicenter Study to Evaluate the Efficacy and Safety of Fexuprazan According to the Timing of Dosing in Patients With Erosive Esophagitis Open
Non-inferiority analysis revealed that taking fexuprazan after meal was non-inferior to taking fexuprazan before meals in patients with EE. The frequency of adverse events was similar between the 2 study groups. The drug is safe and effect…
View article: Update in Association between Lung Cancer and Air Pollution
Update in Association between Lung Cancer and Air Pollution Open
A significant portion of newly diagnosed lung cancer cases occurs in populations exposed to air pollution. The World Health Organization has identified air pollution as a human carcinogen, prompting many countries to implement monitoring s…
View article: Associations between Clinicopathological Characteristics and Intraoperative Opioid Requirements during Endoscopic Submucosal Dissection with Monitored Anesthesia Care: A Retrospective Study
Associations between Clinicopathological Characteristics and Intraoperative Opioid Requirements during Endoscopic Submucosal Dissection with Monitored Anesthesia Care: A Retrospective Study Open
Background and study aims: Endoscopic submucosal dissection is used to treat early gastric neoplasms. Compared with other endoscopic procedures, it requires higher doses of opioids, leading to adverse events during monitored anesthesia car…
View article: Clinical effectiveness of spindle-view intracytoplasmic sperm injection compared to conventional intracytoplasmic sperm injection in patients with poor ovarian response and previous implantation failure
Clinical effectiveness of spindle-view intracytoplasmic sperm injection compared to conventional intracytoplasmic sperm injection in patients with poor ovarian response and previous implantation failure Open
Objective This study aimed to determine the clinical advantage of spindle-view intracytoplasmic sperm injection (SVICSI; a novel technology) over conventional intracytoplasmic sperm injection (cICSI) in patients with poor ovarian response …
View article: Efficacy and safety of CKD-495 in acute and chronic gastritis: A Phase III superiority clinical trial
Efficacy and safety of CKD-495 in acute and chronic gastritis: A Phase III superiority clinical trial Open
Background: Despite the availability of numerous treatment options, many patients with gastritis experience only partial symptom relief. CKD-495, a newly developed product with the active ingredient extracted from Cinnamomum cassia Presl.,…
View article: The 18th Congress of the Asian Association of Endocrine Surgeons—AsAES 2023: Oral Abstract
The 18th Congress of the Asian Association of Endocrine Surgeons—AsAES 2023: Oral Abstract Open
Introduction:Surgical indication of thyroid surgery in small benign nodules is cosmesis.To improve the cosmesis, transoral endoscopic thyroid surgery (TOETVA) is considered one of the best modalities as it gives no visible scar.However, sw…
View article: Evaluation of the Efficacy and Safety of DW1903 in Patients with Gastritis: A Randomized, Double-Blind, Noninferiority, Multicenter, Phase 3 study
Evaluation of the Efficacy and Safety of DW1903 in Patients with Gastritis: A Randomized, Double-Blind, Noninferiority, Multicenter, Phase 3 study Open
DW1903 of a low-dose PPI was not inferior to DW1903R1 of H2RA. Thus, lowdose PPI can be a novel option for treating gastritis (ClinicalTrials.gov Identifier: NCT05163756).
View article: Endoscopically injectable and self‐crosslinkable hydrogel‐mediated stem cell transplantation for alleviating esophageal stricture after endoscopic submucosal dissection
Endoscopically injectable and self‐crosslinkable hydrogel‐mediated stem cell transplantation for alleviating esophageal stricture after endoscopic submucosal dissection Open
Esophageal stricture after extensive endoscopic submucosal dissection impairs the quality of life of patients with superficial esophageal carcinoma. Beyond the limitations of conventional treatments including endoscopic balloon dilatation …
View article: Efficacy and Safety of Fexuprazan in Patients with Acute or Chronic Gastritis
Efficacy and Safety of Fexuprazan in Patients with Acute or Chronic Gastritis Open
Fexuprazan 20 mg q.d. and 10 mg b.i.d. for 2 weeks showed therapeutic efficacy superior to that of placebo in patients with acute or chronic gastritis (ClinicalTrials.gov identifier NCT04341454).
View article: Impact of Coronavirus Disease 2019 on Gastric Cancer Diagnosis and Stage: A Single-Institute Study in South Korea
Impact of Coronavirus Disease 2019 on Gastric Cancer Diagnosis and Stage: A Single-Institute Study in South Korea Open
During the COVID-19 pandemic, the overall number of GC diagnoses decreased significantly in a single institute. Moreover, GCs were in more advanced stages at the time of diagnosis. Further studies are required to elucidate the relationship…
View article: Factors related to Cancer Preventive Behavior among Patients with Early Gastric Cancer who Underwent Endoscopic Submucosal Dissection
Factors related to Cancer Preventive Behavior among Patients with Early Gastric Cancer who Underwent Endoscopic Submucosal Dissection Open
Purpose : The research aimed to investigate the factors affecting cancer preventive behavior among patients with early gastric cancer (EGC) who underwent endoscopic submucosal dissection (ESD).\n\nMethods : Data were collected from 126 pat…
View article: Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis
Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis Open
Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week 8. We suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.
View article: Helicobacter pylori promotes epithelial-to-mesenchymal transition by downregulating CK2β in gastric cancer cells
Helicobacter pylori promotes epithelial-to-mesenchymal transition by downregulating CK2β in gastric cancer cells Open
View article: Metabolic alterations of short-chain fatty acids and TCA cycle intermediates in human plasma from patients with gastric cancer
Metabolic alterations of short-chain fatty acids and TCA cycle intermediates in human plasma from patients with gastric cancer Open
View article: Machine Learning Improves the Prediction Rate of Non-Curative Resection of Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer
Machine Learning Improves the Prediction Rate of Non-Curative Resection of Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer Open
Non-curative resection (NCR) of early gastric cancer (EGC) after endoscopic submucosal dissection (ESD) can increase the burden of additional treatment and medical expenses. We aimed to develop a machine-learning (ML)-based NCR prediction …
View article: Triple Therapy-Based on Tegoprazan, a New Potassium-Competitive Acid Blocker, for First-Line Treatment of <i>Helicobacter pylori</i> Infection: A Randomized, Double-Blind, Phase III, Clinical Trial
Triple Therapy-Based on Tegoprazan, a New Potassium-Competitive Acid Blocker, for First-Line Treatment of <i>Helicobacter pylori</i> Infection: A Randomized, Double-Blind, Phase III, Clinical Trial Open
TPZ is as effective as proton pump inhibitor-based triple therapy and is as safe as first-line H. pylori eradication therapy but does not overcome the clarithromycin resistance of H. pylori in Korea (ClinicalTrials.gov identi…
View article: A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease
A Randomized, Double-Blind, Active-Control, Noninferiority, Multicenter, Phase 4 Study to Evaluate the Efficacy and Safety of Esomeprazole/Sodium Bicarbonate 20/800 mg in Patients with Nonerosive Gastroesophageal Reflux Disease Open
EsoduoⓇ is as effective and safe as NexiumⓇ for managing typical symptoms in patients with NERD (ClinicalTrial.gov identifier: NCT03928470).
View article: Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity
Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity Open
View article: Long-Term Outcomes and Prognostic Factors of Superficial Esophageal Cancer in Patients Aged ≥ 65 Years
Long-Term Outcomes and Prognostic Factors of Superficial Esophageal Cancer in Patients Aged ≥ 65 Years Open
Background The number of elderly patients with superficial esophageal cancer (SEC) is increasing. We aimed to evaluate the clinical outcomes and prognostic factors of overall survival (OS) in elderly patients undergoing endoscopic submucos…
View article: Metabolic Alterations of Short-Chain Fatty Acids and TCA Cycle Intermediates in Human Plasma from Patients with Gastric Cancer
Metabolic Alterations of Short-Chain Fatty Acids and TCA Cycle Intermediates in Human Plasma from Patients with Gastric Cancer Open
View article: Efficacy of radiotherapy for gastric bleeding associated with advanced gastric cancer
Efficacy of radiotherapy for gastric bleeding associated with advanced gastric cancer Open
Background Gastric bleeding negatively impacts the quality of life of patients with unresectable advanced gastric cancer and is frequently lethal. We investigated the efficacy of RT for palliation of gastric bleeding from gastric cancer an…
View article: Human gastric microbiota transplantation recapitulates premalignant lesions in germ-free mice
Human gastric microbiota transplantation recapitulates premalignant lesions in germ-free mice Open
Objective Gastric cancer (GC) is a leading cause of cancer-related mortality. Although microbes besides Helicobacter pylori may also contribute to gastric carcinogenesis, wild-type germ-free (GF) mouse models investigating the role of huma…
View article: Randomised clinical trial: comparison of tegoprazan and placebo in non‐erosive reflux disease
Randomised clinical trial: comparison of tegoprazan and placebo in non‐erosive reflux disease Open
Summary Background Tegoprazan is a novel, fast‐ and long‐acting potassium‐competitive acid blocker that suppresses gastric acid secretion, which could benefit patients with non‐erosive reflux disease (NERD), a type of gastroesophageal refl…
View article: WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury
WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury Open
View article: Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020
Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020 Open
Helicobacter pylori infection is one of the most common infectious diseases worldwide. H. pylori is responsible for substantial gastrointestinal morbidity with a high disease burden. Since the revision of the H. pylori Clinical Practice Gu…