Chanbora Chea
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View article: Effects of novel lactoferrin peptides on <scp>LPS</scp>‐induced alveolar bone destruction in a rat model
Effects of novel lactoferrin peptides on <span>LPS</span>‐induced alveolar bone destruction in a rat model Open
To develop novel bovine lactoferrin (bLF) peptides targeting bLF‐tumour necrosis factor (TNF) receptor‐associated factor 6 (TRAF6) binding sites, we identified two peptides that could target bLF‐TRAF6 binding sites using structural analysi…
View article: Molecular Mechanisms of Inhibitory Effects of Bovine Lactoferrin on Invasion of Oral Squamous Cell Carcinoma
Molecular Mechanisms of Inhibitory Effects of Bovine Lactoferrin on Invasion of Oral Squamous Cell Carcinoma Open
Lactoferrin (LF), an iron-binding glycoprotein, has been reported to have anticancer properties. However, the molecular mechanisms behind its anticancer effects on oral squamous cell carcinoma (OSCC) have not yet been elucidated. Therefore…
View article: Bovine Lactoferrin Suppresses Tumor Angiogenesis through NF-κB Pathway Inhibition by Binding to TRAF6
Bovine Lactoferrin Suppresses Tumor Angiogenesis through NF-κB Pathway Inhibition by Binding to TRAF6 Open
Tumor angiogenesis is essential for tumor progression. The inhibition of tumor angiogenesis is a promising therapy for tumors. Bovine lactoferrin (bLF) has been reported as an anti-tumor agent. However, bLF effects on tumor angiogenesis ar…
View article: Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model
Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model Open
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory bone destruction in which tumor necrosis factor alpha (TNF-α) plays a key role. Bovine lactoferrin (bLF) is a multifunctional protein with anti-inflammatory a…
View article: Knowledge, Practices and Perceptions Regarding the Follow-Up of HIV-Exposed Infants in Cambodia: Perspective of Mothers and Providers
Knowledge, Practices and Perceptions Regarding the Follow-Up of HIV-Exposed Infants in Cambodia: Perspective of Mothers and Providers Open
Cambodian Ministry of Health (MoH) is working towards the elimination of mother-to-child transmission (eMTCT) of HIV by 2025. According to national policy, following the antiretroviral therapy for HIV-positive pregnant women (PW), HIV-expo…
View article: Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition in oral squamous cell carcinoma
Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition in oral squamous cell carcinoma Open
Epithelial-to-mesenchymal transition (EMT) is a biological process of invasion and metastasis in cancers, including in oral squamous cell carcinoma (OSCC). However, an effective anticancer drug that directly targets EMT has not yet been di…
View article: Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer
Interaction between N-cadherin and decoy receptor-2 regulates apoptosis in head and neck cancer Open
N-cadherin is a neural cell adhesion molecule that aberrantly occurs in head and neck cancers to promote cancer cell growth. However, the underlying mechanisms remain unclear. Here we report that N-cadherin increases cancer cell growth by …
View article: Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis
Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis Open
Dental infection is risk for preterm birth (PTB) through unclear mechanisms. We established a dental infection-induced PTB mouse model, in which Porphyromonas gingivalis ( P.g .) induced PTB by 2 days. We analysed pathogenic factors contri…
View article: Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma Open
This is the first report showing that bLF selectively suppresses proliferation through mTOR/S6K and JAK/STAT3 pathways and induction of apoptosis in OSCC. This study provides important new findings, which might be useful in the prevention …
View article: Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma
Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma Open
VEGF-Flt-1 signaling induces osteoclastogenesis in OSCC through two possible ways: 1) VEGF produced from OSCC cells can directly stimulate the Flt-1 pathway in preosteoclasts to induce migration to future bone resorbing area and differenti…
View article: Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells
Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells Open
The lack of response to leptin's actions in the brain, "leptin resistance," is one of the main causes of the pathogenesis of obesity. However, although high-fat diets affect sensitivity to leptin, the underlying mechanisms of leptin resist…