Chandra Childress
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View article: The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy
The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy Open
Our previous studies have shown that the HECT E3 ubiquitin ligase NEDD4 interacts with LC3 and is required for starvation and rapamycin-induced activation of autophagy. Here, we report that NEDD4 directly binds to SQSTM1 via its HECT domai…
View article: The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy
The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy Open
The MAP1LC3/LC3 family plays an essential role in autophagosomal biogenesis and transport. In this report, we show that the HECT family E3 ubiquitin ligase NEDD4 interacts with LC3 and is involved in autophagosomal biogenesis. NEDD4 binds …
View article: PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation Open