Chandra Yallampalli
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View article: Adrenomedullin overexpression protects mice from experimental bronchopulmonary dysplasia and associated pulmonary hypertension
Adrenomedullin overexpression protects mice from experimental bronchopulmonary dysplasia and associated pulmonary hypertension Open
The deficiency of the proangiogenic peptide, adrenomedullin (Adm), exacerbates the severe infantile lung disorder, bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), in mice. However, whether Adm therapy can mitigate th…
View article: Complement activation: in maternal and placental pathology of preeclampsia
Complement activation: in maternal and placental pathology of preeclampsia Open
Preeclampsia is a multifactorial, pregnancy-related disorder characterized by new-onset hypertension and proteinuria, with distinct early- and late-onset forms linked to varying placental and maternal pathologies. While complement system d…
View article: Maternal Low-Protein Diet Leads to Mitochondrial Dysfunction and Impaired Energy Metabolism in the Skeletal Muscle of Male Rats
Maternal Low-Protein Diet Leads to Mitochondrial Dysfunction and Impaired Energy Metabolism in the Skeletal Muscle of Male Rats Open
A prenatal low-protein (LP) diet disrupts glucose homeostasis in adult offspring. Skeletal muscles are one of the main sites of glucose clearance, and mitochondria residing in the muscle fibers are central to glucose homeostasis. Our previ…
View article: The Low Protein Diet induced Fetal Programming Leads to Mitochondrial Dysfunction and Metabolic Inflexibility in the Skeletal Muscle of Male Rats
The Low Protein Diet induced Fetal Programming Leads to Mitochondrial Dysfunction and Metabolic Inflexibility in the Skeletal Muscle of Male Rats Open
A prenatal low-protein (LP) diet disrupts glucose homeostasis in adult offspring. Skeletal muscles are one of the main sites of glucose clearance, and mitochondria residing in the muscle fibers are central to glucose homeostasis. Our previ…
View article: 411 Effect of aspirin on mechanical properties of mesenteric arteries in a mouse model of preeclampsia
411 Effect of aspirin on mechanical properties of mesenteric arteries in a mouse model of preeclampsia Open
View article: Calcitonin gene-related peptide protects from soluble fms-like tyrosine kinase-1-induced vascular dysfunction in a preeclampsia mouse model
Calcitonin gene-related peptide protects from soluble fms-like tyrosine kinase-1-induced vascular dysfunction in a preeclampsia mouse model Open
Introduction: Preeclampsia (PE) is a hypertensive disorder during pregnancy associated with elevated levels of soluble FMS-like tyrosine kinase (sFLT-1) and increased vascular sensitivity to angiotensin II (ATII). Calcitonin gene-related p…
View article: Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte
Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte Open
View article: Low Protein Programming Causes Increased Mitochondrial Fusion and Decreased Oxygen Consumption in the Hepatocytes of Female Rats
Low Protein Programming Causes Increased Mitochondrial Fusion and Decreased Oxygen Consumption in the Hepatocytes of Female Rats Open
The liver is one of the major organs involved in the regulation of glucose and lipid homeostasis. The effectiveness of metabolic activity in hepatocytes is determined by the quality and quantity of its mitochondria. Mitochondrial function …
View article: Feasibility Study of Ferumoxtyol for Contrast-enhanced MRI of Retroplacental Clear Space Disruption in Placenta Accreta Spectrum (PAS)
Feasibility Study of Ferumoxtyol for Contrast-enhanced MRI of Retroplacental Clear Space Disruption in Placenta Accreta Spectrum (PAS) Open
Introduction Placenta accreta spectrum (PAS) occurs when the placenta is pathologically adherent to the myometrium. An intact retroplacental clear space (RPCS) is a marker of normal placentation, but visualization with conventional imaging…
View article: Impact of Adrenomedullin on Mitochondrial Respiratory Capacity in Human Adipocyte
Impact of Adrenomedullin on Mitochondrial Respiratory Capacity in Human Adipocyte Open
For metabolic homeostasis adequate mitochondrial function in adipocytes is essential. Our previous observation showed that circulating levels of adrenomedullin (ADM) and mRNA and protein for ADM in omental adipose tissue were higher in pat…
View article: Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice Open
Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2)…
View article: Nanoparticle Contrast-enhanced MRI for Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta Spectrum (PAS)
Nanoparticle Contrast-enhanced MRI for Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta Spectrum (PAS) Open
View article: Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta
Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta Open
Introduction Prior preclinical studies established the utility of liposomal nanoparticle blood-pool contrast agents in visualizing the retroplacental clear space (RPCS), a marker of normal placentation, while sparing fetuses from exposure …
View article: Lipid dysfunction and adrenomedullin expression in omental versus subcutaneous adipose tissues in diabetic pregnancies
Lipid dysfunction and adrenomedullin expression in omental versus subcutaneous adipose tissues in diabetic pregnancies Open
Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy but the underlying mechanism remains obscure. The aims of this study are to examine if omental adipose tissue (OMAT) and subcutaneous AT (SCAT) differ…
View article: Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion
Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion Open
Gestational diabetes mellitus (GDM) is associated with defective pancreatic β-cell adaptation in pregnancy, but the underlying mechanism remains obscure. Our previous studies demonstrated that GDM women display increased plasma adrenomedul…
View article: Maternal low protein diet and fetal programming of lean type 2 diabetes
Maternal low protein diet and fetal programming of lean type 2 diabetes Open
Maternal nutrition is found to be the key factor that determines fetal health in utero and metabolic health during adulthood. Metabolic diseases have been primarily attributed to impaired maternal nutrition during pregnancy, and imp…
View article: Prenatal Low-Protein Diet Affects Mitochondrial Structure and Function in the Skeletal Muscle of Adult Female Offspring
Prenatal Low-Protein Diet Affects Mitochondrial Structure and Function in the Skeletal Muscle of Adult Female Offspring Open
Gestational low-protein (LP) diet leads to glucose intolerance and insulin resistance in adult offspring. We had earlier demonstrated that LP programming affects glucose disposal in females. Mitochondrial health is crucial for normal gluco…
View article: Table of Contents
Table of Contents Open
View article: Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy
Calcitonin Gene Related Peptide, Adrenomedullin, and Adrenomedullin 2 Function in Uterine Artery During Human Pregnancy Open
Rationale Calcitonin gene-related peptide (CGRP) and its family members adrenomedullin (ADM) and adrenomedullin 2 (ADM2; also known as intermedin) support vascular adaptions in rat pregnancy. Objective This study aimed to assess the relaxa…
View article: Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice
Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice Open
View article: Progesterone receptor isoform B regulates the<i>Oxtr</i>-<i>Plcl2</i>-<i>Trpc3</i>pathway to suppress uterine contractility
Progesterone receptor isoform B regulates the<i>Oxtr</i>-<i>Plcl2</i>-<i>Trpc3</i>pathway to suppress uterine contractility Open
Significance Preterm birth affects 10 to 12% of all pregnancies and is the primary cause of neonatal morbidity and mortality worldwide, while prolonged labor increases the risks of infection, uterine rupture, and neonatal distress. Progest…
View article: Soluble fms-like tyrosine kinase-1 and angiotensin2 target calcitonin gene-related peptide family peptides in maternal vascular smooth muscle cells in pregnancy†
Soluble fms-like tyrosine kinase-1 and angiotensin2 target calcitonin gene-related peptide family peptides in maternal vascular smooth muscle cells in pregnancy† Open
Calcitonin gene-related peptide (CALCB), adrenomedullin (ADM), and adrenomedullin2 (ADM2) are hypotensive peptides that belong to CALCB family of peptides. Goal of this study was to identify the effect of fms-like tyrosine kinase (sFLT-1) …
View article: Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice
Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice Open
View article: In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†
In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats† Open
Sex steroids regulate insulin sensitivity and glucose metabolism. We had characterized a lean type 2 diabetes (T2D) rat model using gestational low-protein (LP) diet programming. Our objective was to identify if endocrine dysfunction leadi…
View article: Complement inhibitor Crry expression in mouse placenta is essential for maintaining normal blood pressure and fetal growth
Complement inhibitor Crry expression in mouse placenta is essential for maintaining normal blood pressure and fetal growth Open
Many circumstantial evidences from human and animal studies suggest that complement cascade dysregulation may play an important role in pregnancy associated complications including preeclampsia. Deletion of rodent specific complement inhib…
View article: Fetal macrosomia in a Hispanic/Latinx predominant cohort and altered expressions of genes related to placental lipid transport and metabolism
Fetal macrosomia in a Hispanic/Latinx predominant cohort and altered expressions of genes related to placental lipid transport and metabolism Open
View article: Common variants of fetal and maternal complement genes in preeclampsia: pregnancy specific complotype
Common variants of fetal and maternal complement genes in preeclampsia: pregnancy specific complotype Open
Preeclampsia (PE) is a pregnancy specific hypertensive disorder. If untreated PE leads to life threatening condition, eclampsia. Systemic complement activation levels are increased during pregnancy compared to non-pregnant women of childbe…
View article: 873: Is hypertension during pregnancy a risk factor for SGA at all gestational ages?
873: Is hypertension during pregnancy a risk factor for SGA at all gestational ages? Open
View article: Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model
Nanoparticle Contrast-enhanced T1-Mapping Enables Estimation of Placental Fractional Blood Volume in a Pregnant Mouse Model Open
View article: Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats
Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats Open
We have characterized a lean type 2 diabetic rat model by gestational low protein programming. We aimed to identify if the regulation of hepatic glucose production (HGP) via gluconeogenesis and glycogenolysis is affected and if there are a…