Chandramathi Samudi Raju
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View article: Low atypical lymphocyte score as a predictor of non-severe dengue
Low atypical lymphocyte score as a predictor of non-severe dengue Open
The study was registered under National Medical Research Registration of Malaysia, (NMRR-18-3347-45473, 1 Sept 2019).
View article: Advancements in molecular techniques impacting the diagnostic landscape for dengue in the near future
Advancements in molecular techniques impacting the diagnostic landscape for dengue in the near future Open
Denue viral epidemics have escalated worldwide, with over 100 million infections occurring annually. The spread of the mosquito vector is supported by the increase in urbanization and climate change with models predicting potential impact …
View article: Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia
Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia Open
The aetiology of schizophrenia is multifactorial, and the identification of its risk factors are scarce and highly variable. A cross-sectional study was conducted to investigate the risk factors associated with schizophrenia among Malaysia…
View article: Enterocytozoon hepatopenaei Infection in Shrimp: Diagnosis, Interventions, and Food Safety Guidelines
Enterocytozoon hepatopenaei Infection in Shrimp: Diagnosis, Interventions, and Food Safety Guidelines Open
The emergence of disease in shrimp has governed much concern in food safety and security among consumers with the recent reports on hepatopancreatic microsporidiosis (HPM) caused by Enterocytozoon hepatopenaei (EHP). The microsporidians pr…
View article: Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles
Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles Open
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the Pacific with antibacterial and/or antifungal activities and analyses their distribution, molecular mass, solubility, and modes of action. All data in t…
View article: Serological cross-reactivity among common flaviviruses
Serological cross-reactivity among common flaviviruses Open
The Flavivirus genus is made up of viruses that are either mosquito-borne or tick-borne and other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to global health and infect up to 400 million of people ann…
View article: Higher amoebic and metronidazole resistant forms of Blastocystis sp. seen in schizophrenic patients
Higher amoebic and metronidazole resistant forms of Blastocystis sp. seen in schizophrenic patients Open
Background Blastocystis sp. is one of the most common colonisers of the intestinal tract that demonstrate strong interaction with accompanying gut bacteria. Previously, the protozoan isolated from individuals with irritable bowel syndrome …
View article: Homologous recombination repair gene mutations in Malaysian prostate cancer patients
Homologous recombination repair gene mutations in Malaysian prostate cancer patients Open
Genetic alterations in the homologous recombination repair (HRR) genes are associated with an increased risk of prostate cancer development, and patients harboring these mutations can benefit from targeted therapy. The main aim of this stu…
View article: Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications
Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications Open
Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharm…
View article: Differential Analysis and Putative Roles of Genes, Cytokines and Apoptotic Proteins in Blood Samples of Patients with Respiratory Viral Infections: A Single Center Study
Differential Analysis and Putative Roles of Genes, Cytokines and Apoptotic Proteins in Blood Samples of Patients with Respiratory Viral Infections: A Single Center Study Open
Insights into the molecular pathogenesis of respiratory viral infections were investigated using serum and peripheral blood from patients with clinical syndromes. Signatures of expression of cytokines, genes and apoptotic proteins that dis…
View article: Evaluation of the antimicrobial and anticancer properties of the fruits of Synsepalum dulcificum (Sapotaceae)
Evaluation of the antimicrobial and anticancer properties of the fruits of Synsepalum dulcificum (Sapotaceae) Open
Purpose: To evaluate the antimicrobial and anticancer activities of the fruit of Synsepalum dulcificum (Sapotaceae) against six bacterial strains and on two different colorectal cancer cell lines, respectively.Methods: The dried fruit of t…
View article: Clinical Investigation and Molecular Diagnosis of Microsporidian Enterocytozoon hepatopenaei (EHP) in Shrimps from Selangor, Malaysia
Clinical Investigation and Molecular Diagnosis of Microsporidian Enterocytozoon hepatopenaei (EHP) in Shrimps from Selangor, Malaysia Open
In recent years, shrimp aquaculture production in Southeast Asia countries was highly infected by, microsporidian parasite, EHP. Recently, shrimps from farms located in Selangor were encountering growth retardation and it highly concerned …
View article: Correlation of host inflammatory cytokines and immune-related metabolites, but not viral NS1 protein, with disease severity of dengue virus infection
Correlation of host inflammatory cytokines and immune-related metabolites, but not viral NS1 protein, with disease severity of dengue virus infection Open
Severe dengue can be lethal caused by manifestations such as severe bleeding, fluid accumulation and organ impairment. This study aimed to investigate the role of dengue non-structural 1 (NS1) protein and host factors contributing to sever…
View article: Identifying protein biomarkers in predicting disease severity of dengue virus infection using immune-related protein microarray
Identifying protein biomarkers in predicting disease severity of dengue virus infection using immune-related protein microarray Open
Dengue virus is one of the most widespread flaviviruses that re-emerged throughout recent decades. The progression from mild dengue to severe dengue (SD) with the complications such as vascular leakage and hemorrhage increases the fatality…
View article: Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh
Antibacterial effects of 18 medicinal plants used by the Khyang tribe in Bangladesh Open
Our study provides evidence that the medicinal plants in Bangladesh have high potential to improve the current treatment strategies for bacterial infection.
View article: Peer Review #1 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.2)"
Peer Review #1 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.2)" Open
Background.Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria.In this study, the mechanisms of action and the therapeutic …
View article: Peer Review #2 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.2)"
Peer Review #2 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.2)" Open
Background.Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria.In this study, the mechanisms of action and the therapeutic …
View article: Peer Review #1 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.3)"
Peer Review #1 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.3)" Open
Background.Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria.In this study, the mechanisms of action and the therapeutic …
View article: Peer Review #2 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.1)"
Peer Review #2 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.1)" Open
Background.Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria.In this study, the mechanisms of action and the therapeutic …
View article: Mechanisms of action and <i>in vivo</i> antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against <i>Streptococcus pneumoniae</i>
Mechanisms of action and <i>in vivo</i> antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against <i>Streptococcus pneumoniae</i> Open
Background Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria. In this study, the mechanisms of action and the therapeutic…
View article: Peer Review #1 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.1)"
Peer Review #1 of "Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae (v0.1)" Open
Background.Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria.In this study, the mechanisms of action and the therapeutic …
View article: Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors
Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors Open
Influenza viruses belong to the family Orthomyxoviridae of enveloped viruses and are an important cause of respiratory infections worldwide. The influenza virus is able to infect a wide variety species as diverse as poultry, marine, pigs, …