Chandran Nagaraj
YOU?
Author Swipe
View article: BK channels are indispensable for endothelial function in small pulmonary arteries
BK channels are indispensable for endothelial function in small pulmonary arteries Open
Background Pulmonary hypertension (PH) is a progressive vascular disease that severely compromises quality of life and survival. The pulmonary endothelium plays a pivotal role in vascular homeostasis through complex signalling networks inv…
View article: Pathobiologie und Genetik der pulmonalen Hypertonie
Pathobiologie und Genetik der pulmonalen Hypertonie Open
Zusammenfassung Die pulmonalarterielle Hypertonie (PAH) ist eine komplexe vaskuläre Erkrankung, die durch eine ausgeprägte pathobiologische und genetische Heterogenität gekennzeichnet ist. Im Rahmen der 7. Weltkonferenz für pulmonale Hyper…
View article: Lipid Ratios for Diagnosis and Prognosis of Pulmonary Hypertension
Lipid Ratios for Diagnosis and Prognosis of Pulmonary Hypertension Open
Rationale: Pulmonary hypertension (PH) poses a significant health threat. Current biomarkers for PH lack specificity and have poor prognostic capabilities. Objectives: To develop better biomarkers for PH that are useful for p…
View article: BK Channels Are Indispensable for Endothelial Function in Small Pulmonary Arteries
BK Channels Are Indispensable for Endothelial Function in Small Pulmonary Arteries Open
Background Pulmonary hypertension (PH) is a progressive vascular disease that severely compromises quality of life and survival. The pulmonary endothelium plays a pivotal role in vascular homeostasis through complex signalling networks inv…
View article: Functionalization of Polycaprolactone 3D Scaffolds with Hyaluronic Acid Glycine-Peptide Conjugates and Endothelial Cell Adhesion
Functionalization of Polycaprolactone 3D Scaffolds with Hyaluronic Acid Glycine-Peptide Conjugates and Endothelial Cell Adhesion Open
This study enhances the bioactivity of polycaprolactone (PCL) scaffolds for tissue engineering by functionalizing them with oxidized hyaluronic acid glycine-peptide conjugates to improve endothelial cell adhesion and growth. Hyaluronic aci…
View article: Pulmonary vascular remodeling in Fra-2 transgenic mice is driven by type 2 inflammation and accompanied by pulmonary vascular hyperresponsiveness
Pulmonary vascular remodeling in Fra-2 transgenic mice is driven by type 2 inflammation and accompanied by pulmonary vascular hyperresponsiveness Open
In patients suffering from systemic sclerosis (SSc), pulmonary arterial hypertension (PAH) is a life-threatening complication linked to immune dysregulation. Preclinical analyses in Fos-related antigen-2 (Fra-2) transgenic (TG) mice, a mod…
View article: Protocol for the fabrication of self-standing (nano)cellulose-based 3D scaffolds for tissue engineering
Protocol for the fabrication of self-standing (nano)cellulose-based 3D scaffolds for tissue engineering Open
Three-dimensional (3D) and porous scaffolds made from nanocellulosic materials hold significant potential in tissue engineering (TE). Here, we present a protocol for fabricating self-standing (nano)cellulose-based 3D scaffolds designed for…
View article: Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response Open
Polyester biomaterials play a crucial in vascular surgery, but suffer from unspecific protein adsorption, thrombogenicity, and inadequate endothelial cell response, which limit their success. To address these issues, we investigated the fu…
View article: The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension
The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension Open
Background and purpose Pulmonary arterial hypertension (PAH) is a progressive disease in which chronic membrane potential (E m ) depolarisation of the pulmonary arterial smooth muscle cells (PASMCs) causes calcium overload, a key pathologi…
View article: Functional Coatings of Antithrombogenic Polysaccharides on Polyester Biomaterials to Improve Hemocompatibility, Protein-Repellence and Endothelial Cell Response
Functional Coatings of Antithrombogenic Polysaccharides on Polyester Biomaterials to Improve Hemocompatibility, Protein-Repellence and Endothelial Cell Response Open
View article: 3D-Printed Collagen–Nanocellulose Hybrid Bioscaffolds with Tailored Properties for Tissue Engineering Applications
3D-Printed Collagen–Nanocellulose Hybrid Bioscaffolds with Tailored Properties for Tissue Engineering Applications Open
Hybrid collagen (Coll) bioscaffolds have emerged as a promising solution for tissue engineering (TE) and regenerative medicine. These innovative bioscaffolds combine the beneficial properties of Coll, an important structural protein of the…
View article: Lipidomics for diagnosis and prognosis of pulmonary hypertension
Lipidomics for diagnosis and prognosis of pulmonary hypertension Open
Background Pulmonary hypertension (PH) poses a significant health threat with high morbidity and mortality, necessitating improved diagnostic tools for enhanced management. Current biomarkers for PH lack functionality and comprehensive dia…
View article: Lipidomics for diagnosis and prognosis of pulmonary hypertension
Lipidomics for diagnosis and prognosis of pulmonary hypertension Open
Pulmonary hypertension (PH) is associated with high morbidity and mortality with an urgent need for diagnostic and prognostic biomarkers. A training cohort of PH patients, disease controls without PH, and healthy controls was investigated …
View article: Lipidomics for diagnosis and prognosis of pulmonary hypertension
Lipidomics for diagnosis and prognosis of pulmonary hypertension Open
Pulmonary hypertension (PH) is associated with high morbidity and mortality with an urgent need for diagnostic and prognostic biomarkers. A training cohort of PH patients, disease controls without PH, and healthy controls was investigated …
View article: 3D‐Printed Anisotropic Nanofiber Composites with Gradual Mechanical Properties
3D‐Printed Anisotropic Nanofiber Composites with Gradual Mechanical Properties Open
3D printing of bio‐based nanomaterials into complex structures with design flexibility, structural anisotropy, and long‐term stability is a key issue for biomedical applications. Herein, 3D‐printed and ionically crosslinked structures with…
View article: Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis
Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis Open
Fine control over chloride homeostasis in the lung is required to maintain membrane excitability, transepithelial transport as well as intra- and extracellular ion and water homeostasis. Over the last decades, a growing number of chloride …
View article: Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation
Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation Open
The transition from the fetal to the neonatal circulation includes dilatation of the pulmonary arteries (PA) and closure of the Ductus Arteriosus Botalli (DAB). The resting membrane potential and various potassium channel activities in smo…
View article: One-Step Fabrication of Hollow Spherical Cellulose Beads: Application in pH-Responsive Therapeutic Delivery
One-Step Fabrication of Hollow Spherical Cellulose Beads: Application in pH-Responsive Therapeutic Delivery Open
The path to greater sustainability and the development of polymeric drug delivery systems requires innovative approaches. The adaptation and use of biobased materials for applications such as targeted therapeutic delivery is, therefore, in…
View article: Chloride Channels in the Lung: Challenges and Perspectives for Viral Infections, Pulmonary Arterial Hypertension, and Cystic Fibrosis
Chloride Channels in the Lung: Challenges and Perspectives for Viral Infections, Pulmonary Arterial Hypertension, and Cystic Fibrosis Open
View article: Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation Open
Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell′s membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in vo…
View article: RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury
RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury Open
The regulator of G protein signaling (RGS) represents a widespread system of controllers of cellular responses. The activities of the R4 subfamily of RGSs have been elucidated in allergic pulmonary diseases. However, the R4 signaling in ot…
View article: Role of Glucagon-Like Peptide -1 Receptor in Pulmonary Circulation
Role of Glucagon-Like Peptide -1 Receptor in Pulmonary Circulation Open
Rationale: Glucagon-like peptide-1 (GLP-1) is a gut-derived incretins secreted in response to nutrient ingestion.It potentiates glucose-dependent insulin secretion and enhance beta-cell mass through regulation of beta-cell proliferation, n…
View article: Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension
Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension Open
Introduction A reduction in pulmonary artery relaxation is a key event in the pathogenesis of pulmonary arterial hypertension (PAH). Cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in airway epithelial cells plays a …
View article: Anticoagulant Activity of Cellulose Nanocrystals from Isora Plant Fibers Assembled on Cellulose and SiO2 Substrates via a Layer-by-Layer Approach
Anticoagulant Activity of Cellulose Nanocrystals from Isora Plant Fibers Assembled on Cellulose and SiO2 Substrates via a Layer-by-Layer Approach Open
In this study, we report the isolation of cellulose nanocrystals (CNCs) from Isora plant fibers by sulfuric acid hydrolysis and their assembly on hydrophilic cellulose and silicon-di-oxide (SiO2) surfaces via a layer-by-layer (LBL) deposit…
View article: Prostaglandin D2 strengthens human endothelial barrier by activation of E-type receptor 4
Prostaglandin D2 strengthens human endothelial barrier by activation of E-type receptor 4 Open
Life-threatening inflammatory conditions such as acute respiratory distress syndrome or sepsis often go hand in hand with severe vascular leakage. During inflammation, endothelial cell integrity and intact barrier function are crucial to l…
View article: ERS International Congress, Madrid, 2019: highlights from the Pulmonary Vascular Diseases Assembly
ERS International Congress, Madrid, 2019: highlights from the Pulmonary Vascular Diseases Assembly Open
The 2019 European Respiratory Society (ERS) International Congress, held in Madrid, Spain, had exciting sessions regarding the field of pulmonary vascular disease. The symposia related to the new ERS/European Society of Cardiology (ESC) Gu…
View article: Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries
Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries Open
Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus…
View article: TMEM16A Potentiation: Possible Drawbacks
TMEM16A Potentiation: Possible Drawbacks Open
View article: Synergistic Effects of Nintedanib and Sildenafil on the Pulmonary Vasculature
Synergistic Effects of Nintedanib and Sildenafil on the Pulmonary Vasculature Open
View article: No indication of insulin resistance in idiopathic pulmonary arterial hypertension with preserved physical activity
No indication of insulin resistance in idiopathic pulmonary arterial hypertension with preserved physical activity Open
There is growing interest in metabolic profiling in pulmonary arterial hypertension (PAH) due to current findings suggesting significant metabolic changes causing pulmonary arterial remodelling and linking PAH to insulin resistance [1]. Su…