Chang Hyeok An
YOU?
Author Swipe
View article: FRI633 Financial Benefits Of Renal Dose-adjusted Dipeptidyl Peptidase-4 Inhibitors For Patients With Type 2 Diabetes And Chronic Kidney Disease: A Multicenter Study Utilizing Common Data Model
FRI633 Financial Benefits Of Renal Dose-adjusted Dipeptidyl Peptidase-4 Inhibitors For Patients With Type 2 Diabetes And Chronic Kidney Disease: A Multicenter Study Utilizing Common Data Model Open
Disclosure: H. Choe: None. Y. Ko: None. S. Moon: None. C.H. Ahn: None. K. Ha: None. H. Lee: None. J. Bae: None. H. Joo: None. H. Lee: None. J. Sohn: None. D. Kim: None. S. Kim: None. K. Kim: None. Y. Cho: None. Objective: To estimate the e…
View article: Supplementary Fig. S5 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S5 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S5. Validation of redundant APC mutations. A, For one case (CRC2), two redundant APC mutations are validated by Sanger sequencing. One nonsense mutation (C>T; left) and one frameshift indel (AG>A; right) are shown for se…
View article: Supplementary Fig. S4 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S4 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S4. Immunohistochemical identification of decreased PCDH9 expression in liver metastasis of a colon cancer. A colon cancer with ITH of PCDH9 deletion identified by both aCGH and qPCR shows positive PCDH9 immunostaining i…
View article: Supplementary Fig. S2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S2. Fraction of biopsy-specific mutations. Per biopsy, the percentage (%) of mutations that are not observed in any other regions in a given sample are shown. Black and purple bars represent primary and metastatic tumors…
View article: Supplementary Fig. S4 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S4 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S4. Immunohistochemical identification of decreased PCDH9 expression in liver metastasis of a colon cancer. A colon cancer with ITH of PCDH9 deletion identified by both aCGH and qPCR shows positive PCDH9 immunostaining i…
View article: Supplementary Fig. S1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S1. Schematic protocol of tissue collection in five colon cancers with liver metastasis. In each colon cancer patient, 2 to 5 tumor fragments each apart at least from 0.5 cm were collected from colon. In parallel, 2 to 6…
View article: Supplementary Fig. S5 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S5 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S5. Validation of redundant APC mutations. A, For one case (CRC2), two redundant APC mutations are validated by Sanger sequencing. One nonsense mutation (C>T; left) and one frameshift indel (AG>A; right) are shown for se…
View article: Supplementary Fig. S1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S1. Schematic protocol of tissue collection in five colon cancers with liver metastasis. In each colon cancer patient, 2 to 5 tumor fragments each apart at least from 0.5 cm were collected from colon. In parallel, 2 to 6…
View article: Supplementary Fig. S3 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S3 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S3. Allele frequencies of spatial mutation catalogs. A, The mutant allele frequencies are shown for the mutations in the five spatial categories. B, Mutant allele frequencies (y-axis) are shown for the total number of mu…
View article: Data from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas
Data from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas Open
Purpose: Gastric adenoma (GA) is a premalignant lesion that precedes intestinal-type gastric carcinoma (GC). However, genetic progression mechanisms from GA to GC have not been clarified.Experimental Design: We performed whol…
View article: Supplementary Fig. S6 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S6 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S6. Phylogenies inferred from the high-confident mutations. (A) The phylogenetic trees inferred from the high-confident mutations or those called in the regions with high sequencing coverage (>50X) are shown for five CRC…
View article: Supplementary Figures from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas
Supplementary Figures from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas Open
Supplementary Fig. S1. Histology of synchronous GAs and GCs. Microscopic features of STC GA01-15 and STC GC01-15 are shown. Black boxes indicate GA or GC lesion. Supplementary Fig. S2. Immunohistochemical staining of MLH1 in STC15. Supplem…
View article: Data from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas
Data from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas Open
Purpose: Gastric adenoma (GA) is a premalignant lesion that precedes intestinal-type gastric carcinoma (GC). However, genetic progression mechanisms from GA to GC have not been clarified.Experimental Design: We performed whol…
View article: Supplementary Table 2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Table 2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Table 2. The mutations observed at least once for the regional biopsies across five CRC genomes. Genomic coordinates are according to hg19. The sequencechanges (Ref and Alt as reference and mutant sequences, respectively) are…
View article: Supplementary Table 1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Table 1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Table 1. Clinicopathological and sequencing information of the cases and regional biopsies
View article: Supplementary_Tables from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas
Supplementary_Tables from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas Open
Supplementary Table S1. The description of whole-exome sequencing data Supplementary Table S2. Somatic point mutations and indels identified across 15 synchronous gastric adenoma and gastric carcinom genomes Supplementary Table S3. Copy nu…
View article: Data from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Data from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Purpose: The intratumoral heterogeneity (ITH) and the evolution of genomic architectures associated with the development of distant metastases are not well understood in colorectal cancers.Experimental Design: We performed mu…
View article: Supplementary Fig. S6 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S6 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S6. Phylogenies inferred from the high-confident mutations. (A) The phylogenetic trees inferred from the high-confident mutations or those called in the regions with high sequencing coverage (>50X) are shown for five CRC…
View article: Supplementary Table 1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Table 1 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Table 1. Clinicopathological and sequencing information of the cases and regional biopsies
View article: Supplementary Table 2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Table 2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Table 2. The mutations observed at least once for the regional biopsies across five CRC genomes. Genomic coordinates are according to hg19. The sequencechanges (Ref and Alt as reference and mutant sequences, respectively) are…
View article: Supplementary Figures from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas
Supplementary Figures from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas Open
Supplementary Fig. S1. Histology of synchronous GAs and GCs. Microscopic features of STC GA01-15 and STC GC01-15 are shown. Black boxes indicate GA or GC lesion. Supplementary Fig. S2. Immunohistochemical staining of MLH1 in STC15. Supplem…
View article: Supplementary Fig. S2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S2 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S2. Fraction of biopsy-specific mutations. Per biopsy, the percentage (%) of mutations that are not observed in any other regions in a given sample are shown. Black and purple bars represent primary and metastatic tumors…
View article: Supplementary_Tables from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas
Supplementary_Tables from Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas Open
Supplementary Table S1. The description of whole-exome sequencing data Supplementary Table S2. Somatic point mutations and indels identified across 15 synchronous gastric adenoma and gastric carcinom genomes Supplementary Table S3. Copy nu…
View article: Data from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Data from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Purpose: The intratumoral heterogeneity (ITH) and the evolution of genomic architectures associated with the development of distant metastases are not well understood in colorectal cancers.Experimental Design: We performed mu…
View article: Supplementary Fig. S3 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity
Supplementary Fig. S3 from Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity Open
Supplementary Fig. S3. Allele frequencies of spatial mutation catalogs. A, The mutant allele frequencies are shown for the mutations in the five spatial categories. B, Mutant allele frequencies (y-axis) are shown for the total number of mu…
View article: ODP028 Association Between Serum Steroid Profile and Metabolic Risks in Adults with Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
ODP028 Association Between Serum Steroid Profile and Metabolic Risks in Adults with Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Open
Objective In adult patients with congenital adrenal hyperplasia (CAH), long-term health outcomes, including metabolic and cardiovascular health, are a priority for the management of CAH. The enzyme 21-hydroxylase deficiency, which accounts…
View article: The role of retinoid-related orphan receptor-α in cigarette smoke-induced autophagic response
The role of retinoid-related orphan receptor-α in cigarette smoke-induced autophagic response Open
Background Retinoid-related orphan receptor-α (RORα) and autophagy dysregulation are involved in the pathophysiology of chronic obstructive pulmonary disease (COPD), but little is known regarding their association. We investigated the role…
View article: Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction
Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction Open
During the preparation of this manuscript, two panels of Figure 9B were inadvertently duplicated, resulting in an incorrect image
View article: Expression of CD133 is associated with poor prognosis in stage II colorectal carcinoma
Expression of CD133 is associated with poor prognosis in stage II colorectal carcinoma Open
CD133 is currently believed to be one of the best colorectal cancer stem cell markers. This study aimed to evaluate prognostic significance of CD133 expression in colorectal cancer patients. A total of 303 patients with stage I to III colo…
View article: Development of Extraction and Analytical Methods of Phenolic Compounds Degraded from Barley Straw in River
Development of Extraction and Analytical Methods of Phenolic Compounds Degraded from Barley Straw in River Open
Both extraction of phenolic acids eluted from barley straw in rivers/lakes and analytical method for the extracted phenolic acids using ultra high performance liquid chromatography (UHPLC)-mass spectroscopy (MS) were developed. Then, the a…