Hong Chen
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View article: A safety assessment method for substation system dynamics adapted to high penetration of distributed renewable energy sources with backward flow delivery
A safety assessment method for substation system dynamics adapted to high penetration of distributed renewable energy sources with backward flow delivery Open
The integration of high-penetration distributed renewable energy sources into new power systems introduces significant challenges, particularly frequent reverse power flows that threaten substation security. To address this issue, this pap…
View article: Newborn screening for fatty acid oxidation disorders: epidemiological and genetic findings in Southeastern China
Newborn screening for fatty acid oxidation disorders: epidemiological and genetic findings in Southeastern China Open
Fatty acid oxidation disorders (FAODs) are a group of rare diseases caused by deficiencies in the function of enzymes or proteins involved in the mitochondrial oxidation of fatty acids. This study aimed to analyze the incidence, disease sp…
View article: #2215 Development and validation of nomograms for predicting the activity index of lupus nephritis
#2215 Development and validation of nomograms for predicting the activity index of lupus nephritis Open
Background and Aims Lupus nephritis (LN) is a common and severe complication of systemic lupus erythematosus (SLE). The initial treatment strategy for LN is guided by pathological features, with the activity index (AI) being a key predicto…
View article: #2328 Exploring the role of KDM6A as a regulator of proximal tubular epithelial cell dysmetabolism in diabetic kidney disease
#2328 Exploring the role of KDM6A as a regulator of proximal tubular epithelial cell dysmetabolism in diabetic kidney disease Open
Background and Aims Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and progresses faster in males. In DKD, proximal tubular epithelial cells (PTECs) increase the breakdown of glucose (via glycolysis) and gluta…
View article: Effects of nutritional support during neoadjuvant therapy on perioperative outcome in esophageal cancer: a real-world cohort study
Effects of nutritional support during neoadjuvant therapy on perioperative outcome in esophageal cancer: a real-world cohort study Open
Nasogastric tube feeding plays a pivotal role in effective nutritional support during neoadjuvant therapy. Effective nutritional intervention not only improves preoperative nutritional status and enhances neoadjuvant therapy completion but…
View article: Application of Biomarkers in Spinal Muscular Atrophy
Application of Biomarkers in Spinal Muscular Atrophy Open
Spinal muscular atrophy (SMA) is a fatal motor neuron disease characterized by five clinical subtypes, each presenting with different rates of disease progression and varying responses to recently approved therapies. The identification of …
View article: A comprehensive analysis of BMI prediction using machine learning and biochemical markers: Insights from NHANES data
A comprehensive analysis of BMI prediction using machine learning and biochemical markers: Insights from NHANES data Open
This study investigates the relationship between obesity and common biochemical markers, focusing on renal function indicators, using machine learning models to diagnose body mass index (BMI) and identify clinically relevant markers associ…
View article: Development and validation of nomograms for predicting activity index and tubulointerstitial lesions in lupus nephritis: a multicentre study
Development and validation of nomograms for predicting activity index and tubulointerstitial lesions in lupus nephritis: a multicentre study Open
Objective Lupus nephritis (LN) is a prevalent renal manifestation in patients with SLE, with kidney biopsy remaining the gold standard for evaluating disease activity. However, the invasive nature of biopsy and associated risks highlight t…
View article: Phase II basket trial of Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: pancreatic neuroendocrine neoplasm (PNEN) cohort
Phase II basket trial of Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) SWOG S1609: pancreatic neuroendocrine neoplasm (PNEN) cohort Open
Purpose SWOG S1609 D ual A nti-CTLA-4 and anti-PD-1 blockade in R are T umors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neopla…
View article: Network of anxiety and depression symptoms in older Chinese adults living alone: a cross-sectional study
Network of anxiety and depression symptoms in older Chinese adults living alone: a cross-sectional study Open
Background With the rapid aging of China’s population, the proportion of older adults living alone has increased significantly, bringing their mental health concerns into sharp focus. This study aims to explore the network structure of anx…
View article: Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study
Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study Open
Peripheral nerve injury (PNI) remains a significant clinical challenge, often leading to long-term functional impairment. Despite advances in therapies, current repair strategies offer unsatisfactory clinical outcomes. Exosomes derived fro…
View article: Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia
Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia Open
Small extracellular vesicles (sEVs), including exosomes as a subtype, with a diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting a diverse array of bioactive molecules, including prote…
View article: Research trends and hotspots in the surgical treatment of peripheral nerve injuries of the upper limb from 2000 to 2024: a bibliometric visualization study
Research trends and hotspots in the surgical treatment of peripheral nerve injuries of the upper limb from 2000 to 2024: a bibliometric visualization study Open
Purpose Surgical treatment plays a crucial role in the management of peripheral nerve injuries of the upper limb, but little bibliometric analysis has been conducted on it. This study was aimed to examine the global trends and hotspots in …
View article: Electroacupuncture Preconditioning Ameliorates the Ischemic Microenvironment to Improve Long‐Term Potentiation in Chronic Cerebral Hypoperfusion Rats With MGE Neural Progenitor Transplantation
Electroacupuncture Preconditioning Ameliorates the Ischemic Microenvironment to Improve Long‐Term Potentiation in Chronic Cerebral Hypoperfusion Rats With MGE Neural Progenitor Transplantation Open
Background: Vascular cognitive impairment (VCI) is the second most common type of cognitive impairment in the world after Alzheimer’s disease (AD). At present, there is no specific drug for VCI. This study aims to confirm the role of elect…
View article: Next-Generation Neurotechnologies Inspired by Motor Primitive Model for Restoring Human Natural Movement
Next-Generation Neurotechnologies Inspired by Motor Primitive Model for Restoring Human Natural Movement Open
Advances in neuroengineering and artificial intelligence are transforming the landscape of motor rehabilitation, aiming to restore human movement as natural as possible. In recent decades, more advanced interventions are increasingly achie…
View article: SAM Decoding: Speculative Decoding via Suffix Automaton
SAM Decoding: Speculative Decoding via Suffix Automaton Open
Speculative decoding (SD) has been demonstrated as an effective technique for lossless LLM inference acceleration. Retrieval-based SD methods, one kind of model-free method, have yielded promising speedup, but they often rely on incomplete…
View article: Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives Open
“Peripheral nerve injury” refers to damage or trauma affecting nerves outside the brain and spinal cord. Peripheral nerve injury results in movements or sensation impairments, and represents a serious public health problem. Although severe…
View article: Advances in stem cell therapy for diabetic foot
Advances in stem cell therapy for diabetic foot Open
Diabetic Foot Ulcers (DFU) represent a grave complication often encountered in the advanced stages of diabetes mellitus. They frequently lead to recurrent hospitalizations and, in severe cases, can result in life-threatening conditions suc…
View article: Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia
Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia Open
Importance Comparisons are limited for immediate-intensive and delayed-intensive statin for secondary stroke prevention and neuroprotection in patients with acute mild ischemic stroke or transient ischemic attack (TIA) from atherosclerosis…
View article: Directed differentiation of human embryonic stem cells into parathyroid cells and establishment of parathyroid organoids
Directed differentiation of human embryonic stem cells into parathyroid cells and establishment of parathyroid organoids Open
Differentiation of human embryonic stem cells (hESCs) into human embryonic stem cells‐derived parathyroid‐like cells (hESC‐PT) has clinical significance in providing new therapies for congenital and acquired parathyroid insufficiency condi…
View article: Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in spinal muscular atrophy and amyotrophic lateral sclerosis
Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in spinal muscular atrophy and amyotrophic lateral sclerosis Open
Tropomyosin receptor kinase B (TrkB) and its primary ligand brain-derived neurotrophic factor (BDNF) are expressed in the neuromuscular system, where they affect neuronal survival, differentiation, and functions. Changes in BDNF levels and…