Shengyu Wang
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View article: The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression Open
This study identifies CLIC1 as a novel metabolic regulator that drives glycolytic reprogramming through direct interaction with PKM2 in gastric cancer. Targeting the CLIC1-PKM2 axis may provide a promising therapeutic strategy for metaboli…
View article: Nano-Silica-Modified Hydrophobic PDMS Encapsulation on CNT Thermoelectric Fibers for Waterproof Thermoelectric Textiles
Nano-Silica-Modified Hydrophobic PDMS Encapsulation on CNT Thermoelectric Fibers for Waterproof Thermoelectric Textiles Open
Flexible and wearable thermoelectric devices can convert body waste heat into electricity, showing a new direction to solve the long-lasting issue of energy supply on portable devices. However, thermoelectric fibers are prone to short circ…
View article: CLIC1 regulates cellular oxidative stress and gastric cancer progress by enhancing ACOX1 ubiquitination
CLIC1 regulates cellular oxidative stress and gastric cancer progress by enhancing ACOX1 ubiquitination Open
Oxidative stress is a two-edged sword for tumors. However, how oxidative stress influences tumor progression remains unclear. We determined that chloride intracellular channel 1 (CLIC1) accelerates gastric cancer progression by enhancing a…
View article: CrackNet-Weather: An Effective Pavement Crack Detection Method Under Adverse Weather Conditions
CrackNet-Weather: An Effective Pavement Crack Detection Method Under Adverse Weather Conditions Open
Accurate pavement crack detection under adverse weather conditions is essential for road safety and effective pavement maintenance. However, factors such as reduced visibility, background noise, and irregular crack morphology make this tas…
View article: Task Offloading Strategy of Multi-Objective Optimization Algorithm Based on Particle Swarm Optimization in Edge Computing
Task Offloading Strategy of Multi-Objective Optimization Algorithm Based on Particle Swarm Optimization in Edge Computing Open
With the rapid development of edge computing and deep learning, the efficient deployment of deep neural networks (DNNs) on resource-constrained terminal devices faces multiple challenges (background), such as execution delay, high energy c…
View article: Synthesis and Biological Evaluation of Small Molecule Inhibitors of Immune Cytopenias
Synthesis and Biological Evaluation of Small Molecule Inhibitors of Immune Cytopenias Open
Immune cytopenias are a group of autoimmune disorders where patients develop autoantibodies against certain types of blood cells such as red blood cells (RBCs) or thrombocytes. We investigated small molecules as potential inhibitors of pha…
View article: Artificial intelligence for reducing missed detection of adenomas and polyps in colonoscopy: A systematic review and meta-analysis
Artificial intelligence for reducing missed detection of adenomas and polyps in colonoscopy: A systematic review and meta-analysis Open
BACKGROUND Colorectal cancer has a high incidence and mortality rate, and the effectiveness of routine colonoscopy largely depends on the endoscopist’s expertise. In recent years, computer-aided detection (CADe) systems have been increasin…
View article: Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer
Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer Open
Background Frizzled class receptor 2 (FZD2), is a critical protein in the Wnt signaling pathway, which plays significant roles in various cancers. However, its role in cancer progression, prognosis, and diagnosis remains largely unexplored…
View article: Clinical characteristics and risk factors of hospital mortality in elderly patients with community-acquired pneumonia
Clinical characteristics and risk factors of hospital mortality in elderly patients with community-acquired pneumonia Open
Background Community-acquired pneumonia (CAP) leads to high morbidity and mortality among the elderly, with 3 million deaths annually worldwide. Multiple comorbidities significantly increase the risk. This study aims to identify independen…
View article: Restoration of X-ray backscatter images under low exposure time based on deep learning
Restoration of X-ray backscatter images under low exposure time based on deep learning Open
Lobster-eye lenses are suitable for staring hard X-ray backscattering imaging, but achieving clear imaging typically requires a long exposure time. This study establishes a noise model for imaging under low-exposure conditions, investigate…
View article: Food for thought: Rosy-faced lovebirds (Agapornis roseicollis) are capable of associative symbol learning and inference-based quantity discrimination
Food for thought: Rosy-faced lovebirds (Agapornis roseicollis) are capable of associative symbol learning and inference-based quantity discrimination Open
Cognitive capacity for quantity discrimination is highly adaptive in various ecological contexts and subject to convergent evolution across diverse animal species, yet the underlying mechanism involved is not fully understood. Discriminati…
View article: Applications of Nanotechnology for Spatial Omics: Biological Structures and Functions at Nanoscale Resolution
Applications of Nanotechnology for Spatial Omics: Biological Structures and Functions at Nanoscale Resolution Open
Spatial omics methods are extensions of traditional histological methods that can illuminate important biomedical mechanisms of physiology and disease by examining the distribution of biomolecules, including nucleic acids, proteins, lipids…
View article: Assimilation of Satellite-Derived Reservoir Storage Data to Improve Global Hydrodynamic Modeling
Assimilation of Satellite-Derived Reservoir Storage Data to Improve Global Hydrodynamic Modeling Open
In this study, we explore the potential of assimilating satellite-derived reservoir storage data into the global-scale hydrodynamic model CaMa-Flood, focusing on the Yangtze River basin. We evaluated three data assimilation (DA) methods: d…
View article: Assessment of synthetic MRI to distinguish Warthin’s tumor from pleomorphic adenoma in the parotid gland: comparison of two methods of positioning the region of interest for synthetic relaxometry measurement
Assessment of synthetic MRI to distinguish Warthin’s tumor from pleomorphic adenoma in the parotid gland: comparison of two methods of positioning the region of interest for synthetic relaxometry measurement Open
Purpose To assess the diagnostic potential of the synthetic MRI (SyMRI) for differentiating Warthin’s tumors (WT) from pleomorphic adenomas (PA). Materials and methods Forty-nine individuals with parotid gland tumors (PA, n = 23; WT, n = 2…
View article: Variation of All-Cause Mortality with Fat-Free Mass Index (FFMI) and Fat Mass Index (FMI) in Individuals with Asthma: Results from the NHANES Database Retrospective Cohort Study
Variation of All-Cause Mortality with Fat-Free Mass Index (FFMI) and Fat Mass Index (FMI) in Individuals with Asthma: Results from the NHANES Database Retrospective Cohort Study Open
The study shows that both high FMI and low FFMI are associated with increased mortality in patients with asthma. These findings underscore the critical role of FMI and FFMI in the health management of asthma patients. Therefore, it is reco…
View article: Identification and validation of potential prognostic biomarkers in glioblastoma via the mesenchymal stem cell infiltration level
Identification and validation of potential prognostic biomarkers in glioblastoma via the mesenchymal stem cell infiltration level Open
Aims Mesenchymal stem cells (MSCs) are key components in promoting glioblastoma (GBM) progression. This study aimed to explore new therapeutic targets and related pathogenic mechanisms based on different MSCs infiltration levels in GBM pat…
View article: Can a Policy Mix Achieve a Collaborative Effect? Exploring the Nested Implementation Process of Urban Carbon Emission Reduction Policies
Can a Policy Mix Achieve a Collaborative Effect? Exploring the Nested Implementation Process of Urban Carbon Emission Reduction Policies Open
China’s government has adopted several carbon emission reduction policies to strive to achieve the dual carbon goal of “carbon peaking and carbon neutrality”. In practice, various multi-objective policy instruments are implemented in a sta…
View article: Research on deep learning restoration algorithm of X-ray backscatter imaging based on virtual training dataset
Research on deep learning restoration algorithm of X-ray backscatter imaging based on virtual training dataset Open
The X-ray lobster eye lens, an innovative technique for focusing high-energy radiation, enables wide-field X-ray imaging. However, its inherent cross point spread function introduces noise and degradation into the resultant images. Convent…
View article: Percutaneous transhepatic choledochoscopy in the management of hepatolithiasis: a narrative review
Percutaneous transhepatic choledochoscopy in the management of hepatolithiasis: a narrative review Open
Although PTCS is frequently used as an adjunctive therapeutic approach, its distinct utility in treating intrahepatic bile duct stones remains difficult to replace. Thus, a deeper understanding of PTCS-related complications, coupled with o…
View article: Variation of all-cause mortality with Fat-free Mass Index（FFMI）and Fat Mass Index（FMI）in individuals with Asthma: results from the NHANES database prospective cohort study
Variation of all-cause mortality with Fat-free Mass Index（FFMI）and Fat Mass Index（FMI）in individuals with Asthma: results from the NHANES database prospective cohort study Open
Background The relationship between FFMI, FMI, and mortality in patients with asthma remains unknown. This study aimed to examine the associations between FFMI and FMI and all-cause mortality in a cohort of American adults diagnosed with a…
View article: Development of a deep learning survival model to predict the individual risks of peritoneal metastasis of colorectal cancer
Development of a deep learning survival model to predict the individual risks of peritoneal metastasis of colorectal cancer Open
Background : Peritoneal metastasis (PM) has been considered to be the terminal stage of colorectal cancer (CRC) due to poor prognosis. We purposed to construct an AI model of clinicopathological parameters to predict the survival prognosis…
View article: Discussion on the relationship between gut microbiota and glioma through Mendelian randomization test based on the brain gut axis
Discussion on the relationship between gut microbiota and glioma through Mendelian randomization test based on the brain gut axis Open
Background In the realm of Gut-Brain axis research, existing evidence points to a complex bidirectional regulatory mechanism between gut microbiota and the brain. However, the question of whether a causal relationship exists between gut mi…
View article: CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1
CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1 Open
Downregulation of CRYAB boosted FTH1 degradation and increased cellular Fe and ROS levels, and finally improved the ferroptosis and lessened the osteogenic differentiation of BMSCs.
View article: Role of STIM1 in stretch-induced signaling in human airway smooth muscle
Role of STIM1 in stretch-induced signaling in human airway smooth muscle Open
Mechanical forces on the airway can contribute to altered contractility and remodeling in airway diseases, but the mechanisms are not clearly understood. Using human airway smooth muscle cells exposed to cyclic forces with static stretch t…
View article: Outcomes of Mitral Valve Repair for Posterior Leaflet Prolapse, Anterior Leaflet Prolapse, and Bileaflet Prolapse
Outcomes of Mitral Valve Repair for Posterior Leaflet Prolapse, Anterior Leaflet Prolapse, and Bileaflet Prolapse Open
Background: Mitral valve repair (MVr) is an effective treatment for degenerative mitral regurgitation (DMR).And the outcomes and repair rates for posterior leaflet prolapse (PLP), anterior leaflet prolapse (ALP), and bileaflet prolapse (BL…
View article: Diabetes Prediction Using Random Forest in Healthcare
Diabetes Prediction Using Random Forest in Healthcare Open
Accurate diabetes prediction has emerged as a crucial problem in the field of healthcare. It is important to detect individuals at risk of having diabetes, which can allow for prompt intervention and tailored treatment strategies. Nowadays…
View article: The effect of surgery started at different time point during the day on the clinical outcomes of mitral valve surgery
The effect of surgery started at different time point during the day on the clinical outcomes of mitral valve surgery Open
Background The clinical prognosis of mitral valve surgery at morning, afternoon, and evening is not yet clear. The aim of the study is to investigate the impact of different time periods of surgery in the morning, afternoon and evening on …