Explanipedia

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging Open

Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean , et al. · 2025

Loss of regeneration is a key feature of aging organs, often linked to stem cell exhaustion. Skeletal muscle stem cells (MuSCs) undergo age‐related numerical and functional decline, contributing to reduced regenerative potential. Using low…

Publisher Correction: Senolytic effects of a modified Gingerenone A Open

Ruin Moaddel, Chad Sanehira, Gregory S. Keyes, Chang‐Yi Cui, Reza Ahmadkhaniha , et al. · 2025

Senolytic effects of a modified Gingerenone A Open

Ruin Moaddel, Chad Sanehira, Gregory S. Keyes, Chang‐Yi Cui, Reza Ahmadkhania , et al. · 2025

Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of peop…

Protein Kinase A Regulates the Cell Cycle to Affect the Induction Rate in the Parthenogenetic Reproduction of the Silkworm, Bombyx mori Open

Fang Xu, Wei Yu, Chao Ma, Chengjie Hu, Chang‐Yi Cui , et al. · 2025

Protein kinase A (PKA), commonly referred to as cAMP-dependent protein kinase, exists as a heterotetramer composed of two catalytic (C) and regulatory subunits (R). This versatile kinase exhibits regulatory functions in various biological …

Reducing <span>HuD</span> Levels Alleviates Alzheimer's Disease Pathology in <span>5xFAD</span> Mice Open

Eunbyul Ji, Apala Pal, Quia Claybourne, Marc Michel, Rachel Munk , et al. · 2025

Alzheimer's disease (AD) is the most common neurodegenerative pathology in older persons. The accumulation of amyloid β (Aβ) plaques is a major contributor to AD development. The RNA‐binding protein HuD/ELAVL4 has been implicated in the fo…

Decreased Cdk2 Activity Hindered Embryonic Development and Parthenogenesis Induction in Silkworm, Bombyx mori L. Open

Chengjie Hu, Yonghou Jiang, Chao Ma, Fang Xu, Chang‐Yi Cui , et al. · 2025

Cyclin-dependent protein kinase 2 (Cdk2), an important member of the serine/threonine-specific protein kinase family, plays a critical regulatory role in biological processes. Previous studies have demonstrated that Cdk2 is involved in the…

MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, Bombyx mori Open

Chao Ma, Fang Xu, Chengjie Hu, Chang‐Yi Cui, Xin Du , et al. · 2025

In most species, oocytes are arrested at the prophase or metaphase of meiosis I and require sperm-derived or external stimuli to resume meiosis. Maturation-promoting factor (MPF) is an oocyte maturation factor composing the catalytic subun…

PPARs Activity Affects the Hatchability Through Lipid Metabolism Regulation in Silkworm, Bombyx mori L. Open

Xia Xu, Chang‐Yi Cui, Xin Du, Jine Chen, Xiuling He , et al. · 2025

Lipid metabolism serves as the primary energy source for organisms. Silkworm eggs for spring use are divided into two types: autumn-produced eggs for next spring rearing (AS) and spring-produced eggs for next spring rearing (SS). Productio…

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging Open

James R. Occean, Na Yang, Yan Sun, Marshall S. Dawkins, Rachel Munk , et al. · 2024

DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been imp…

Characterization of age-associated gene expression changes in mouse sweat glands Open

Alexandra G. Zonnefeld, Chang‐Yi Cui, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan , et al. · 2024

Evaporation of sweat on the skin surface is the major mechanism for dissipating heat in humans. The secretory capacity of sweat glands (SWGs) declines during aging, leading to heat intolerance in the elderly, but the mechanisms responsible…

The YAP–TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress Open

Carlos Anerillas, Krystyna Mazan-Mamczarz, Allison B. Herman, Rachel Munk, Kwan-Wood Gabriel Lam , et al. · 2023

Survey of organ‐derived small extracellular vesicles and particles (sEVPs) to identify selective protein markers in mouse serum Open

Kotb Abdelmohsen, Allison B. Herman, Angelica E. Carr, Charnae' Henry-Smith, Martina Rossi , et al. · 2023

Extracellular vesicles and particles (EVPs) are secreted by organs across the body into different circulatory systems, including the bloodstream, and reflect pathophysiologic conditions of the organ. However, the heterogeneity of EVPs in t…

A hyper-quiescent chromatin state formed during aging is reversed by regeneration Open

Na Yang, James R. Occean, Daniël P. Melters, Changyou Shi, Lin Wang , et al. · 2023

Macrophage Involvement in Aging-Associated Skeletal Muscle Regeneration Open

Chang‐Yi Cui, Luigi Ferrucci, Myriam Gorospe · 2023

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective tissues, blood vessels and nerve endings. Its main function is to provide motility to the body, but it is also deeply involved in systemic metabolism …

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging Open

James R. Occean, Na Yang, Yan Sun, Marshall S. Dawkins, Rachel Munk , et al. · 2023

DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been imp…

A hyper-quiescent chromatin state formed during aging is reversed by regeneration Open

Na Yang, James R. Occean, Daniël P. Melters, Changyou Shi, Lin Wang , et al. · 2023

Summary Epigenetic alterations are a key hallmark of aging but have been limitedly explored in tissues. Here, using naturally aged murine liver as a model and extending to other quiescent tissues, we find that aging is driven by temporal c…

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress Open

Carlos Anerillas, Krystyna Mazan-Mamczarz, Allison B. Herman, Rachel Munk, Kwan-Wood Gabriel Lam , et al. · 2023

Sublethal cell damage can trigger a complex adaptive program known as senescence, characterized by growth arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP). As senescent cells accumulating in aging org…

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress Open

Carlos Anerillas, Krystyna Mazan-Mamczarz, Allison B. Herman, Rachel Munk, Kwan-Wood Gabriel Lam , et al. · 2022

Sublethal cell damage can trigger a complex adaptive program known as senescence, characterized by growth arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP). As senescent cells accumulating in aging org…

Author Correction: A BDNF-TrkB autocrine loop enhances senescent cell viability Open

Carlos Anerillas, Allison B. Herman, Rachel Munk, Amanda Garrido, Kwan-Wood Gabriel Lam , et al. · 2022

SINGLE-CELL ANALYSIS OF SKELETAL MUSCLE MACROPHAGES REVEALS AGE-ASSOCIATED FUNCTIONAL SUBPOPULATIONS Open

Chang‐Yi Cui, Linda K Krasniewski, Papiya Chakraborty, Krystyna Mazan-Mamczarz, Luigi Ferrucci , et al. · 2022

Tissue-resident macrophages represent a group of highly responsive innate immune cells that acquire diverse functions by polarizing towards distinct subpopulations. The subpopulations of macrophages that reside in skeletal muscle (SKM) and…

A BDNF-TrkB autocrine loop enhances senescent cell viability Open

Carlos Anerillas, Allison B. Herman, Rachel Munk, Amanda Garrido, Kwan-Wood Gabriel Lam , et al. · 2022

Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells secrete pro-inflammatory and tissue-remodeling factors. Given that the SASP exacerbate…

Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations Open

Linda K Krasniewski, Papiya Chakraborty, Chang‐Yi Cui, Krystyna Mazan-Mamczarz, Christopher Dunn , et al. · 2022

Tissue-resident macrophages represent a group of highly responsive innate immune cells that acquire diverse functions by polarizing toward distinct subpopulations. The subpopulations of macrophages that reside in skeletal muscle (SKM) and …

Author response: Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations Open

Linda K Krasniewski, Papiya Chakraborty, Chang‐Yi Cui, Krystyna Mazan-Mamczarz, Christopher Dunn , et al. · 2022

Proteomes of primary skin fibroblasts from healthy individuals reveal altered cell responses across the life span Open

Dimitrios Tsitsipatis, Jennifer L. Martindale, Ceereena Ubaida‐Mohien, Alexey E. Lyashkov, Hagai Yanai , et al. · 2022

Changes in the proteome of different human tissues with advancing age are poorly characterized. Here, we studied the proteins present in primary skin fibroblasts collected from 82 healthy individuals across a wide age spectrum (22–89 years…

Early SRC activation skews cell fate from apoptosis to senescence Open

Carlos Anerillas, Allison B. Herman, Martina Rossi, Rachel Munk, Elin Lehrmann , et al. · 2022

Cells responding to DNA damage implement complex adaptive programs that often culminate in one of two distinct outcomes: apoptosis or senescence. To systematically identify factors driving each response, we analyzed human IMR-90 fibroblast…

A BDNF-TrkB autocrine loop enhances senescent cell viability Open

Carlos Anerillas, Allison B. Herman, Rachel Munk, Matthew J. Payea, Martina Rossi , et al. · 2022

Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells secrete pro-inflammatory and tissue-remodeling factors. Given that the SASP exacerbate…

Improved Macrophage Enrichment from Mouse Skeletal Muscle Open

Linda K Krasniewski, Dimitrios Tsitsipatis, Elizabeth Izydore, Changyou Shi, Yulan Piao , et al. · 2022

Macrophages are a heterogeneous class of innate immune cells that offer a primary line of defense to the body by phagocytizing pathogens, digesting them, and presenting the antigens to T and B cells to initiate adaptive immunity. Through s…

GRSF1 deficiency in skeletal muscle reduces endurance in aged mice Open

Riley K. Driscoll, Linda K Krasniewski, Samuel G. Cockey, Jen‐Hao Yang, Yulan Piao , et al. · 2021

GRSF1 is a mitochondrial RNA-binding protein important for maintaining mitochondrial function. We found that GRSF1 is highly expressed in cultured skeletal myoblasts differentiating into myotubes. To understand the physiological function o…

SRC activation skews cell fate from apoptosis to senescence Open

Carlos Anerillas, Allison B. Herman, Martina Rossi, Rachel Munk, Elin Lehrmann , et al. · 2021

Cells responding to DNA damage implement complex adaptive programs that often culminate in two distinct outcomes: apoptosis or senescence. To systematically identify factors driving each response, we analyzed human IMR-90 fibroblasts expos…

Macrophages in skeletal muscle aging Open

Chang‐Yi Cui, Luigi Ferrucci · 2020

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