Changyou Gao
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View article: Preparation and bioactivities of selenium nanoparticles based on a polysaccharide from Dendrobium huoshanense
Preparation and bioactivities of selenium nanoparticles based on a polysaccharide from Dendrobium huoshanense Open
The present work reported the preparation and characterization of a polysaccharide (DPHs-1) from Dendrobium huoshanense and its influence on bioactivities of selenium nanoparticles (DPH-SeNPs). DPH-SeNPs were synthesized using DPHs-1 as st…
View article: MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction
MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction Open
Regeneration therapeutic strategy by microRNAs for boosting cardiomyocyte proliferation in treating myocardial infarction (MI) has the challenges of efficient delivery, and toxicity and risk of sudden death. Herein, oxidative stress-relief…
View article: A self-sacrificing anti-inflammatory coating promotes simultaneous cardiovascular repair and reendothelialization of implanted devices
A self-sacrificing anti-inflammatory coating promotes simultaneous cardiovascular repair and reendothelialization of implanted devices Open
During interventional surgeries of implantable cardiovascular devices in addressing cardiovascular diseases (CVD), the inevitable tissue damage will trigger host inflammation and vascular lumen injury, leading to delayed re-endothelization…
View article: Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis
Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA is tightly linked to the intricate immunological milieu, i…
View article: Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment
Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment Open
Myocardial infarction (MI) is a leading cause of death globally. Stem cell therapy is considered a potential strategy for MI treatment. Transplantation of classic stem cells including embryonic, induced pluripotent and cardiac stem cells e…
View article: Thermosensitive Hydrogel with Programmable, Self‐Regulated HIF‐1α Stabilizer Release for Myocardial Infarction Treatment
Thermosensitive Hydrogel with Programmable, Self‐Regulated HIF‐1α Stabilizer Release for Myocardial Infarction Treatment Open
HIF‐1α (hypoxia induced factor‐1α), a vital protective signal against hypoxia, has a short lifetime after myocardial infarction (MI). Increasing HIF‐1α stability by inhibiting its hydroxylation with prolyl hydroxylases inhibitors such as D…
View article: Advances of surface modification to alleviate oxidative stress-induced valve degeneration
Advances of surface modification to alleviate oxidative stress-induced valve degeneration Open
Valvular heart disease (VHD) is a significant public health threat, with heart valve replacement surgery being the standard treatment for severe cases. Despite of advancements in artificial heart valves, their longevity remains limited due…
View article: ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis
ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis Open
Primary sclerosing cholangitis (PSC) is a challenging cholestatic liver disease marked by progressive bile duct inflammation and fibrosis that has no FDA-approved therapy. Although obeticholic acid (OCA) has been sanctioned for PSC, its cl…
View article: Milk-derived haem scavenging microsponges protect heart against ferroptosis-induced reperfusion injury
Milk-derived haem scavenging microsponges protect heart against ferroptosis-induced reperfusion injury Open
Myocardial ischemia/reperfusion injury with a high incidence of intramyocardial haemorrhage (IMH) contributes to enlarged infarct size by inducing additional cell death and predisposes to risk of heart failure. However, the risk factor in …
View article: Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis
Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis Open
Skin pathological fibrosis conditions, such as hypertrophic scars (HS) and keloids, where the scar tissue is raised and extends beyond the original wound boundary, are aesthetically unappealing and sometimes painful or itchy, significantly…
View article: Correction: Near-infrared light triggered photothermal therapy and enhanced photodynamic therapy with a tumor-targeting hydrogen peroxide shuttle
Correction: Near-infrared light triggered photothermal therapy and enhanced photodynamic therapy with a tumor-targeting hydrogen peroxide shuttle Open
Correction for ‘Near-infrared light triggered photothermal therapy and enhanced photodynamic therapy with a tumor-targeting hydrogen peroxide shuttle’ by Bing Wang et al. , J. Mater. Chem. B , 2018, 6 , 3145–3155, https://doi.org/10.1039/C…
View article: Correction: Encapsulation of a photosensitizer into cell membrane capsules for photodynamic therapy
Correction: Encapsulation of a photosensitizer into cell membrane capsules for photodynamic therapy Open
Correction for ‘Encapsulation of a photosensitizer into cell membrane capsules for photodynamic therapy’ by Lijie Han et al. , RSC Adv. , 2016, 6 , 37212–37220, https://doi.org/10.1039/C6RA07480D.
View article: A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds
A tough, antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds Open
Wound management is an important issue that places enormous pressure on the physical and mental health of patients, especially in cases of infection, where the increased inflammatory response could lead to severe hypertrophic scars (HSs). …
View article: Delivery of dental pulp stem cells by an injectable ROS-responsive hydrogel promotes temporomandibular joint cartilage repair via enhancing anti-apoptosis and regulating microenvironment
Delivery of dental pulp stem cells by an injectable ROS-responsive hydrogel promotes temporomandibular joint cartilage repair via enhancing anti-apoptosis and regulating microenvironment Open
Temporomandibular joint (TMJ) cartilage repair poses a considerable clinical challenge, and tissue engineering has emerged as a promising solution. In this study, we developed an injectable reactive oxygen species (ROS)-responsive multifun…
View article: Correction: Near-infrared light triggered photothermal and photodynamic therapy with an oxygen-shuttle endoperoxide of anthracene against tumor hypoxia
Correction: Near-infrared light triggered photothermal and photodynamic therapy with an oxygen-shuttle endoperoxide of anthracene against tumor hypoxia Open
Correction for ‘Near-infrared light triggered photothermal and photodynamic therapy with an oxygen-shuttle endoperoxide of anthracene against tumor hypoxia’ by Zheng Yuan et al. , Polym. Chem. , 2018, 9 , 2124–2133, DOI: https://doi.org/10…
View article: PLGA micro/nanoparticle vaccination elicits non-tumor antigen specific resident memory CD8<sup>+</sup> T cell protection from hepatocellular carcinoma
PLGA micro/nanoparticle vaccination elicits non-tumor antigen specific resident memory CD8<sup>+</sup> T cell protection from hepatocellular carcinoma Open
Non-tumor antigen specific CD8+ memory T cells (TRMs) can be activated by vaccination and work synergistically with tumor-specific T cells for anti-tumor immunity.
View article: Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks
Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks Open
Conductive cardiac patches can help to restore electric signal conduction of the diseased myocardium after myocardial infarction (MI). However, none of the conductive cardiac patches reported in literature has entered clinical trials. Benc…
View article: A Sequential Dual Functional Supramolecular Hydrogel with Promoted Drug Release to Scavenge ROS and Stabilize HIF‐1α for Myocardial Infarction Treatment
A Sequential Dual Functional Supramolecular Hydrogel with Promoted Drug Release to Scavenge ROS and Stabilize HIF‐1α for Myocardial Infarction Treatment Open
Myocardial infarction (MI) has a characteristic inflammatory microenvironment due to the overproduction of reactive oxygen species (ROS) and causes the extraordinary deposition of collagen and thereby fibrosis. An on‐demand adaptive drug r…
View article: A biodegradable, flexible photonic patch for in vivo phototherapy
A biodegradable, flexible photonic patch for in vivo phototherapy Open
Diagnostic and therapeutic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photon…
View article: Prosthetic heart valves for transcatheter aortic valve replacement
Prosthetic heart valves for transcatheter aortic valve replacement Open
Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aor…
View article: Submicron‐Sized In Situ Osmotic Pressure Sensors for In Vitro Applications in Biology
Submicron‐Sized In Situ Osmotic Pressure Sensors for In Vitro Applications in Biology Open
Physical forces are important cues in determining the development and the normal function of biological tissues. While forces generated by molecular motors have been widely studied, forces resulting from osmotic gradients have been less co…
View article: Submicron-sized <i>in-situ</i> osmotic pressure sensors for <i>in-vitro</i> applications in biology
Submicron-sized <i>in-situ</i> osmotic pressure sensors for <i>in-vitro</i> applications in biology Open
Physical forces are important cues in determining the development and the normal function of biological tissues. While forces generated by molecular motors have been widely studied, forces resulting from osmotic gradients have been less co…
View article: Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair
Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair Open
Background: In this study, a new composite biological mesh named SFP was prepared by combining silk fibroin with polypropylene mesh. The mechanism and clinical application value of the SFP composite mesh were explored. Methods: The fibrous…
View article: Physiologically Responsive Polyurethanes for Tissue Repair and Regeneration
Physiologically Responsive Polyurethanes for Tissue Repair and Regeneration Open
Polyurethanes have been broadly used as biomaterials in tissue repair and regeneration due to their preeminent biocompatibility and mechanical properties. However, traditional polyurethanes are not able to efficiently cope with the complex…
View article: Recent study advances in the Department of Polymer Science and Engineering at Zhejiang University
Recent study advances in the Department of Polymer Science and Engineering at Zhejiang University Open
The polymer science at Zhejiang University (ZJU) is well known for its foremost origin of study and education of polymers in China. According to the latest US News rankings, it is ranked third in the subject of Polymer Sciences. The Depart…