Changyun Liu
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View article: The role of VCAM1 in post-stroke cognitive impairment: Molecular mechanisms and therapeutic potential
The role of VCAM1 in post-stroke cognitive impairment: Molecular mechanisms and therapeutic potential Open
Ischemic stroke constitutes a critical medical condition that can lead to post-stroke cognitive impairment (PSCI), yet the underlying molecular mechanisms remain incompletely understood. This study investigated the role of vascular cell ad…
View article: Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke
Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke Open
Introduction Ischemic stroke is a leading cause of mortality and disability worldwide, with limited therapeutic options and high rates of recurrence. Mitochondrial dysfunction plays a critical role in neuronal injury during ischemia-reperf…
View article: High‐permeability cellulose nanocrystals mediate systemic zinc redistribution through <scp>nsLTP2</scp>‐dependent immune potentiation in plants
High‐permeability cellulose nanocrystals mediate systemic zinc redistribution through <span>nsLTP2</span>‐dependent immune potentiation in plants Open
Summary Zinc (Zn 2+ ) is an essential micronutrient that regulates plant growth, immunity and antiviral defence mechanisms. However, its limited bioavailability often necessitates excessive application, resulting in inefficiencies in produ…
View article: <scp>NbTLP1</scp> stabilizes <scp>NbPR1</scp> to enhance resistance against <i>Phytophthora capsici</i> via salicylic acid signalling pathway in <i>Nicotiana benthamiana</i>
<span>NbTLP1</span> stabilizes <span>NbPR1</span> to enhance resistance against <i>Phytophthora capsici</i> via salicylic acid signalling pathway in <i>Nicotiana benthamiana</i> Open
In summary, our study establishes that NbTLP1 plays a crucial role in mediating the SA signalling pathway, thereby contributing to the suppression of P. capsici infection through its interaction with NbPR1 to form a heterodimer. These find…
View article: Identification and management of a novel Danshen leaf anthracnose caused by Colletotrichum karstii in Salvia miltiorrhiza Bunge in China
Identification and management of a novel Danshen leaf anthracnose caused by Colletotrichum karstii in Salvia miltiorrhiza Bunge in China Open
Danshen ( Salvia miltiorrhiza Bunge), a member of the genus Salvia within the Lamiaceae family, holds significant economic and medicinal value. Regrettably, the emergence of a novel leaf anthracnose in 2020 has significantly impacted its c…
View article: A bi-kinase module sensitizes and potentiates plant immune signaling
A bi-kinase module sensitizes and potentiates plant immune signaling Open
Systemic signaling is an essential hallmark of multicellular life. Pathogen encounter occurs locally but triggers organ-scale and organismic immune responses. In plants, elicitor perception provokes systemically expanding Ca 2+ and H 2 O 2…
View article: The high-permeability cellulose nanocrystals carrier facilitates zinc utilization and enhances nsLTP2-mediated plant immunity
The high-permeability cellulose nanocrystals carrier facilitates zinc utilization and enhances nsLTP2-mediated plant immunity Open
Zinc (Zn2+) is an essential micronutrient that regulates plant growth, immunity, and antiviral defense mechanisms. However, its limited bioavailability often necessitates excessive application, resulting in inefficiencies in pro…
View article: Combining Streptomyces griseoaurantiacus strain SSH1 with Carbendazim for enhanced management of tomato gray mold by mimicking B. cinerea–induced transcriptional reprogramming
Combining Streptomyces griseoaurantiacus strain SSH1 with Carbendazim for enhanced management of tomato gray mold by mimicking B. cinerea–induced transcriptional reprogramming Open
View article: Inhibition of <i>Monilinia fructicola</i> sporulation and pathogenicity through eucalyptol‐mediated targeting of <i>MfCat2</i> by <i>Streptomyces lincolnensis</i> strain <scp>JCP1</scp> ‐7
Inhibition of <i>Monilinia fructicola</i> sporulation and pathogenicity through eucalyptol‐mediated targeting of <i>MfCat2</i> by <i>Streptomyces lincolnensis</i> strain <span>JCP1</span> ‐7 Open
Peach brown rot, attributed to Monilinia fructicola , presents a significant threat to postharvest peach cultivation, causing losses of up to 80%. With an increasing number of countries, spearheaded by the European Union, imposing bans on …
View article: Integrated transcriptome and metabolome reveal that SlSYTA modulates ROS responses driving resistance defense in <i>Solanum lycopersicum</i>
Integrated transcriptome and metabolome reveal that SlSYTA modulates ROS responses driving resistance defense in <i>Solanum lycopersicum</i> Open
Synaptotagmin A (SYTA), renowned for its indispensable role in mammalian vesicle trafficking, has recently captured attention in plant biology owing to its potential regulatory functions. This study meticulously delves into the involvement…
View article: Unraveling <i>NbCML30</i>-Mediated Defense Against <i>Sclerotinia Sclerotiorum</i> and <i>Phytophthora Capsici</i> in <i>Nicotiana Benthamiana</i>: A Transcriptomic Perspective
Unraveling <i>NbCML30</i>-Mediated Defense Against <i>Sclerotinia Sclerotiorum</i> and <i>Phytophthora Capsici</i> in <i>Nicotiana Benthamiana</i>: A Transcriptomic Perspective Open
View article: Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects Open
View article: Double whammy: the genetic variants in CECR2 and high Hcy on the development of neural tube defects
Double whammy: the genetic variants in CECR2 and high Hcy on the development of neural tube defects Open
Introduction: Neural tube defects (NTDs) are serious congenital malformations. The etiology of NTDs involves both genetic and environmental factors. Loss of CECR2 in mice has been shown to result in NTDs. Our previous study indicated that …
View article: Harnessing Streptomyces Biocontrol for Managing Chinese Cabbage Clubroot Disease
Harnessing Streptomyces Biocontrol for Managing Chinese Cabbage Clubroot Disease Open
View article: Biosynthesized silver nanoparticles inhibit Pseudomonas syringae pv. tabaci by directly destroying bacteria and inducing plant resistance in Nicotiana benthamiana
Biosynthesized silver nanoparticles inhibit Pseudomonas syringae pv. tabaci by directly destroying bacteria and inducing plant resistance in Nicotiana benthamiana Open
View article: Tobacco mosaic virus hijacks its coat protein‐interacting protein <scp>IP‐L</scp> to inhibit <scp>NbCML30</scp>, a calmodulin‐like protein, to enhance its infection
Tobacco mosaic virus hijacks its coat protein‐interacting protein <span>IP‐L</span> to inhibit <span>NbCML30</span>, a calmodulin‐like protein, to enhance its infection Open
SUMMARY Calcium is an important plant immune signal that is essential for activating host resistance, but how RNA viruses manipulate calcium signals to promote their infections remains largely unknown. Here, we demonstrated that tobacco mo…
View article: <i>Nicotiana benthamiana</i> asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway
<i>Nicotiana benthamiana</i> asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway Open
Asparagine synthetase is a key enzyme that catalyses the conversion of amide groups from glutamine or ammonium to aspartate, which leads to the generation of asparagine. However, the role of asparagine synthetase in plant immunity remains …
View article: Investigation on Alternobaric Vertigo of Gradational Simulated Saturation Diving with the Deepest Saturation of 480m to -493m
Investigation on Alternobaric Vertigo of Gradational Simulated Saturation Diving with the Deepest Saturation of 480m to -493m Open
Objective To provide medical support for deep helium-oxygen saturation diving. Methods According to the data, the diagnostic criteria of Alternobaric vertigo were established. Gradational simulated saturation diving at 65 m, 250 m and 480m…
View article: Study on the Relationship Between Divers&apos; Behavior Types and Sleep Structure
Study on the Relationship Between Divers' Behavior Types and Sleep Structure Open
Objective: To observe the relationship between divers' behavior types and sleep, and to provide basis for divers' medical support. Methods: 86 divers were randomly selected to conduct behavior type questionnaire, and 10 divers of various t…
View article: Multi-sensor scheduling method based on Cuckoo and Particle Swarm optimization algorithm
Multi-sensor scheduling method based on Cuckoo and Particle Swarm optimization algorithm Open
In order to solve the problem that particle swarm optimization (PSO) tends to fall into the local optimal solution and the convergence speed is slow when solving multi-sensor resource scheduling model, a cuckoo particle swarm optimization …
View article: Genome-wide analysis of NDR1/HIN1-like genes in pepper (Capsicum annuum L.) and functional characterization of CaNHL4 under biotic and abiotic stresses
Genome-wide analysis of NDR1/HIN1-like genes in pepper (Capsicum annuum L.) and functional characterization of CaNHL4 under biotic and abiotic stresses Open
Plant NDR1/HIN1-like ( NHL ) genes play an important role in triggering plant defenses in response to biotic stresses. In this study, we performed a genome-wide identification of the NHL genes in pepper ( Capsicum annuum L.) and characteri…
View article: Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects
Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects Open
Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC. H…
View article: Cellulose Nanocrystal Surface Cationization: A New Fungicide with High Activity against Phycomycetes capsici
Cellulose Nanocrystal Surface Cationization: A New Fungicide with High Activity against Phycomycetes capsici Open
At present, the management of Phytophthora capsici (P. capsici) mainly relies on chemical pesticides. However, along with the resistance generated by P. capsici to these chemical pesticides, the toxicity and non-degradability of this chemi…
View article: Folate deficiency facilitates coordination of KDM6A with p53 in response to DNA damage
Folate deficiency facilitates coordination of KDM6A with p53 in response to DNA damage Open
Folate contributes to the accumulation of DNA strand breaks (DSBs) in the genome. Kdm6a plays a critical role in early embryogenesis but it is unknown whether Kdm6a is involved in the DNA damage response under folate deficiency. Here, we e…
View article: A NEW ADAPTIVE TRACKING ALGORITHM FOR NEAR-SPACE HYPERSONIC TARGET
A NEW ADAPTIVE TRACKING ALGORITHM FOR NEAR-SPACE HYPERSONIC TARGET Open
View article: Changes in sleep architecture and quality in minimal hepatic encephalopathy patients and relationship to psychological dysfunction.
Changes in sleep architecture and quality in minimal hepatic encephalopathy patients and relationship to psychological dysfunction. Open
MHE patients suffer from multiple subjective dyssomnias and changes in sleep architecture that are strongly correlated with psychological dysfunction.