Changfei Li
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View article: Integrating single-cell omics and materials science for uveal melanoma: from mechanistic insights to precision therapeutics
Integrating single-cell omics and materials science for uveal melanoma: from mechanistic insights to precision therapeutics Open
Uveal melanoma (UM), the most common primary intraocular malignancy in adults, presents significant clinical challenges due to its high metastatic potential, pronounced hepatic tropism, and poor prognosis upon systemic dissemination. Despi…
View article: Rupestonic Acid Derivative YZH-106 Promotes Lysosomal Degradation of HBV L- and M-HBsAg via Direct Interaction with PreS2 Domain
Rupestonic Acid Derivative YZH-106 Promotes Lysosomal Degradation of HBV L- and M-HBsAg via Direct Interaction with PreS2 Domain Open
Hepatitis B surface antigen (HBsAg) is not only the biomarker of hepatitis B virus (HBV) infection and expression activity in hepatocytes, but it also contributes to viral specific T cell exhaustion and HBV persistent infection. Therefore,…
View article: Rupestonic Acid Derivative YZH-106 Promotes Lysosomal Degradation of HBV L- and M-HBsAg via Direct Interaction with PreS2 Domain
Rupestonic Acid Derivative YZH-106 Promotes Lysosomal Degradation of HBV L- and M-HBsAg via Direct Interaction with PreS2 Domain Open
Hepatitis B surface antigen (HBsAg) is not only the biomarker of hepatitis B virus (HBV) infection and expression activity in hepatocytes, but also contributes to viral specific T cell exhaustion and HBV persistent infection. Therefore, an…
View article: Sequential Evolution of Residual Liquefaction in a Silty Seabed: Effect of Wave-Loading History
Sequential Evolution of Residual Liquefaction in a Silty Seabed: Effect of Wave-Loading History Open
Multiple liquefaction events may occur if a seabed is subjected to repeated but intermittent wave loadings. This study aimed to investigate the influence of the wave-loading history on the evolution of residual liquefaction in a silty seab…
View article: GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma
GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma Open
The placenta and tumors can exhibit a shared expression profile of proto-oncogenes. The basis of placenta-derived heat shock protein gp96, which induces prophylactic and therapeutic T cell responses against cancer including hepatocellular …
View article: Robot service failure and recovery: Literature review and future directions
Robot service failure and recovery: Literature review and future directions Open
Robot service failure and subsequent user behavioral responses have emerged as a prominent scientific issue, warranting attention from multiple disciplines. A review of existing literature is crucial to synthesizing and comprehensively eva…
View article: Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma
Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma Open
Alpha-fetoprotein (AFP) is the most widely used biomarker for the diagnosis of hepatocellular carcinoma (HCC). However, a substantial proportion of HCC patients have either normal or marginally increased AFP levels in serum, and the underl…
View article: Technological Innovation, Product Quality and Upgrading of Manufacturing Value Chain: Empirical Evidence from China
Technological Innovation, Product Quality and Upgrading of Manufacturing Value Chain: Empirical Evidence from China Open
The aim of this research is to investigate the relationship between enterprise technological innovation, export product quality, and the upgrading of the manufacturing value chain. The study is based on panel data from Chinese manufacturin…
View article: To Achieve a Bullseye: Factors Related to Corneal Refractive Therapy Orthokeratology Lens Toricity
To Achieve a Bullseye: Factors Related to Corneal Refractive Therapy Orthokeratology Lens Toricity Open
This retrospective study investigated the toricity of dual-axis corneal refractive therapy (CRT) orthokeratology lenses and corneal parameters, including flat keratometry (FK), flat eccentricity (e), steep e, corneal astigmatism, and the d…
View article: Cellular gp96 upregulates AFP expression by blockade of NR5A2 SUMOylation and ubiquitination in HCC
Cellular gp96 upregulates AFP expression by blockade of NR5A2 SUMOylation and ubiquitination in HCC Open
AFP is the most widely used biomarker for the diagnosis of hepatocellular carcinoma. However, a substantial proportion of HCC patients have either normal or marginally increased AFP levels in serum, and the underlying mechanisms are not fu…
View article: Cellular gp96 upregulates AFP expression by blockade of NR5A2 SUMOylation and ubiquitination in HCC
Cellular gp96 upregulates AFP expression by blockade of NR5A2 SUMOylation and ubiquitination in HCC Open
AFP is the most widely used biomarker for the diagnosis of hepatocellular carcinoma. However, a substantial proportion of HCC patients have either normal or marginally increased AFP levels in serum, and the underlying mechanisms are not fu…
View article: MHC Class I Assembly Function and Intracellular Transport Routes for Hepatitis B Virus Antigen Cross-presentation by Heat Shock Protein gp96
MHC Class I Assembly Function and Intracellular Transport Routes for Hepatitis B Virus Antigen Cross-presentation by Heat Shock Protein gp96 Open
Background: During hepatitis B virus (HBV) infection, virus-infected hepatocytes directly cross-present viral antigens and regulate T cell response within the liver microenvironment. However, little is known regarding the regulatory pathwa…
View article: Breaking-Wave Induced Transient Pore Pressure in a Sandy Seabed: Flume Modeling and Observations
Breaking-Wave Induced Transient Pore Pressure in a Sandy Seabed: Flume Modeling and Observations Open
Previous studies on wave-induced pore pressure in a porous seabed mainly focused on non-breaking regular waves, e.g., Airy linear waves or Stokes non-linear waves. In this study, breaking-wave induced pore pressure response in a sandy seab…
View article: Withdrawal: The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway
Withdrawal: The lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (PH) and FYVE domains (LAPF), representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via the lysosomal-mitochondrial pathway Open
This article has been withdrawn by the authors.The Journal states there is inappropriate image manipulation of a repeating pattern in the background of the LAPF and actin immunoblots in Fig. 3B.There are also multiple inappropriate image m…
View article: Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage
Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage Open
Liver failure leads to the massive necrosis of hepatocytes, releasing large amounts of intracellular components including damage-associated molecular patterns (DAMPs). We found that extracellular gp96 levels in serum were elevated in patie…
View article: PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response
PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response Open
Programmed death ligand 1 (PD-L1) has been recently shown to be a major obstacle to antiviral immunity by binding to its receptor programmed death 1 (PD-1) on specific IFN-γ producing T cells in chronic hepatitis B. Currently, IFN-α is wid…
View article: MicroRNA-532 inhibits cell growth and metastasis in retinoblastoma by targeting MDM4
MicroRNA-532 inhibits cell growth and metastasis in retinoblastoma by targeting MDM4 Open
Background Now, numerous microRNAs (miRNAs) are found to exert effect in retinoblastoma (RB). This research mainly focused on the function of miR-532 in RB, which has not been investigated. Methods RT-qPCR and Western blot analysis were us…
View article: Association between Serum Cytokeratin-18 Neoepitope M30 (CK-18 M30) Levels and Chronic Hepatitis B: A Meta-Analysis
Association between Serum Cytokeratin-18 Neoepitope M30 (CK-18 M30) Levels and Chronic Hepatitis B: A Meta-Analysis Open
Background: Cytokeratin-18 Neoepitope M30 (CK-18 M30) has been reported to be associated with chronic HBV infection and severity of liver injury; however, the results of these studies are inconsistent. Objectives: We sought to investigate …
View article: Additional file 3: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
Additional file 3: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer Open
Table S3. Shared miRNAs binding sites prediction in human HER2 and HER4 3â UTR. (XLSX 12 kb)
View article: Additional file 4: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
Additional file 4: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer Open
Table S4. miRNAs binding sites prediction in human HER2 and HER3 3â UTR. (XLSX 26 kb)
View article: Additional file 1: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
Additional file 1: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer Open
Table S1. Gene fold changes in T47D cells transfected with HER2â 3â UTR or control vector. (XLSX 891 kb)
View article: Additional file 2: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
Additional file 2: of Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer Open
Table S2. Gene-set enrichment analysis in T47D cells transfected with HER2â 3â UTR or control vector. (XLSX 37 kb)
View article: Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5
Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5 Open
Dissection and understanding of the molecular pathways driving triple-negative breast cancer (TNBC) are urgently needed to develop efficient tailored therapies. Aside from cell invasion and metastasis, the urokinase-type plasminogen activa…