Changgui Zhao
YOU?
Author Swipe
View article: Organocatalytic Enantio-, Atrop-, and Diastereoselective Macrocyclization of Quinone Methides
Organocatalytic Enantio-, Atrop-, and Diastereoselective Macrocyclization of Quinone Methides Open
View article: Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes
Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes Open
View article: Conformationally Defined Planar-Chiral [n]Paracyclophanes Stabilized by Chiral Ansa Chains
Conformationally Defined Planar-Chiral [n]Paracyclophanes Stabilized by Chiral Ansa Chains Open
Although chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrat…
View article: N-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution
N-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution Open
Planar-chiral cyclophanes have gained considerable concerns for drug discovery due to their unique conformational strain and 3D structure. However, the enantioselective synthesis of planar-chiral cyclophanes is a long-standing challenge fo…
View article: CCDC 2263320: Experimental Crystal Structure Determination
CCDC 2263320: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2262970: Experimental Crystal Structure Determination
CCDC 2262970: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings
A Lewis Acid-Promoted Michael Addition and Ring-Expansion Cascade for the Construction of Nitrogen-Containing Medium-Sized Rings Open
A Lewis acid-promoted annulation of azadienes and cyclobutamines was developed. This reaction proceeded through Michael addition and ring-expansion cascade, affording the corresponding nitrogen-containing medium-sized rings with a broad sc…
View article: A Review on Generation and Reactivity of the N-Heterocyclic Carbene-Bound Alkynyl Acyl Azolium Intermediates
A Review on Generation and Reactivity of the N-Heterocyclic Carbene-Bound Alkynyl Acyl Azolium Intermediates Open
N-heterocyclic carbene (NHC) has been widely used as an organocatalyst for both umpolung and non-umpolung chemistry. Previous works mainly focus on species including Breslow intermediate, azolium enolate intermediate, homoenolate intermedi…
View article: Recent Advances for the Construction of Seven-Membered Ring Catalyzed by N-Heterocyclic Carbenes
Recent Advances for the Construction of Seven-Membered Ring Catalyzed by N-Heterocyclic Carbenes Open
The seven-membered rings represent an important structural motif and have found wide presence in natural products, biologically active molecules and drugs.In contrast to the five-and six-membered rings, the construction of sevenmembered ri…
View article: Asymmetric reactions of N-heterocyclic carbene (NHC)-based chiral acyl azoliums and azolium enolates
Asymmetric reactions of N-heterocyclic carbene (NHC)-based chiral acyl azoliums and azolium enolates Open
N-Heterocyclic carbene (NHC) organocatalysis has been recognized as a powerful synthetic strategy for the construction of a wide variety of medicinally and biologically important molecules. Although NHCs are known as the umpolung of aldehy…
View article: A marine microbiome antifungal targets urgent-threat drug-resistant fungi
A marine microbiome antifungal targets urgent-threat drug-resistant fungi Open
Prospecting for antifungal molecules Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et a…
View article: A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings
A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings Open
View article: Intermolecular Regio‐ and Stereoselective Hetero‐[5+2] Cycloaddition of Oxidopyrylium Ylides and Cyclic Imines
Intermolecular Regio‐ and Stereoselective Hetero‐[5+2] Cycloaddition of Oxidopyrylium Ylides and Cyclic Imines Open
We have developed the first intermolecular hetero‐[5+2] cycloaddition reaction between oxidopyrylium ylides and cyclic imines with excellent control of regio‐ and stereoselectivity. Surprisingly, divergent stereochemistry was observed depe…
View article: Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes
Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes Open
View article: Correction: N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams
Correction: N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams Open
Correction for ‘N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams’ by Fangyi Li, et al., Org. Chem. Front., 2016, 3, 335–338.
View article: N-Heterocyclic Carbene Catalyzed and<i>N</i>-Fluorobenzenesulfonimide Mediated Oxidative Synthesis of Perester and Amide
N-Heterocyclic Carbene Catalyzed and<i>N</i>-Fluorobenzenesulfonimide Mediated Oxidative Synthesis of Perester and Amide Open
The first study of oxidative synthesis of simple tert-butyl peresters and amides enabled by N-heterocyclic carbene-catalysis using N-fluorobenzenesulfonimide (NFSI) as oxidant is described.The reaction proceeds with green, high yield, boar…