Changhui Yan
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View article: Identifying Key Hub Genes that Attribute Varying Host Responses: A Longitudinal RNA-seq Analysis of SARS-CoV-2 Delta and Omicron Infections
Identifying Key Hub Genes that Attribute Varying Host Responses: A Longitudinal RNA-seq Analysis of SARS-CoV-2 Delta and Omicron Infections Open
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has severely impacted global health, with different Variants of Concern (VOCs) resulting in varied clinical outcomes. Among these, the Delta and Omicron variants have drawn signifi…
View article: Determination of the fracture closure pressure in fractural-cavity carbonate reservoirs using a failure criterion based on asperity behavior
Determination of the fracture closure pressure in fractural-cavity carbonate reservoirs using a failure criterion based on asperity behavior Open
As fluid flow paths in fractural-cavity carbonate reservoirs, fractures have a significant impact on the production performance of carbonate reservoirs. In particular, well production depends on the apertures of the fractures, which vary w…
View article: VirusT5: Harnessing Large Language Models to Predicting SARS-CoV-2 Evolution
VirusT5: Harnessing Large Language Models to Predicting SARS-CoV-2 Evolution Open
During a virus's evolution,various regions of the genome are subjected to distinct levels of functional constraints.Combined with factors like codon bias and DNA repair efficiency,these constraints contribute to unique mutation patterns wi…
View article: Optimization of the Preparation Process of Glucuronomannan Oligosaccharides and Their Effects on the Gut Microbiota in MPTP-Induced PD Model Mice
Optimization of the Preparation Process of Glucuronomannan Oligosaccharides and Their Effects on the Gut Microbiota in MPTP-Induced PD Model Mice Open
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder, and accumulating evidence suggests a link between dysbiosis of the gut microbiota and the onset and progression of PD. In our previous investigations, we discovered that i…
View article: High-Throughput Phenotyping of Seed Quality Traits Using Imaging and Deep Learning in Dry Pea
High-Throughput Phenotyping of Seed Quality Traits Using Imaging and Deep Learning in Dry Pea Open
Seed traits, such as seed color and seed size, directly impact seed quality, affecting the marketability and value of dry peas [1]. Assessing seed quality is integral to a plant breeding programs to ensure optimal seed standards. This rese…
View article: Detection of Violent Scenes in Cartoon Movies Using a Deep Learning Approach
Detection of Violent Scenes in Cartoon Movies Using a Deep Learning Approach Open
Cartoon movies are a primary source of entertainment for children. However, concerns arise when these movies inadvertently expose children to violent scenes. This paper addresses the challenge of detecting subtle instances of violence with…
View article: The selection of reference genome and the search for the origin of SARS-CoV-2
The selection of reference genome and the search for the origin of SARS-CoV-2 Open
s The pandemic caused by SARS-CoV-2 has a great impact on the whole world. In a theory of the origin of SARS-CoV-2, pangolins were considered a potential intermediate host. To assemble the coronavirus found in pangolins, SARS-CoV-2 were us…
View article: An Enrichment Method For Mapping Ambiguous Reads To Reference Genome For NGS Analysis
An Enrichment Method For Mapping Ambiguous Reads To Reference Genome For NGS Analysis Open
Mapping short reads to a reference genome is an essential step in many next- generation sequencing (NGS) analysis. In plants with large genomes, a large fraction of the reads can align to multiple locations of the genome with equally good …
View article: Comparative Genome Analysis of 2 <i>Mycobacterium Tuberculosis</i> Strains from Pakistan: Insights Globally Into Drug Resistance, Virulence, and Niche Adaptation
Comparative Genome Analysis of 2 <i>Mycobacterium Tuberculosis</i> Strains from Pakistan: Insights Globally Into Drug Resistance, Virulence, and Niche Adaptation Open
Multidrug-resistant Mycobacterium tuberculosis is a global threat particularly in developing countries like Pakistan. In this study, we identified 2 M tuberculosis strains, mnpk and swlpk, by 16S RNA genes, sequenced their draft genome, an…
View article: Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing
Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing Open
Initiation of eukaryotic chromosome replication follows a spatiotemporal program. The current model suggests that replication origins compete for a limited pool of initiation factors. However, it remains to be answered how these limiting f…
View article: Genome-wide homology analysis reveals new insights into the origin of the wheat B genome
Genome-wide homology analysis reveals new insights into the origin of the wheat B genome Open
Wheat is a typical allopolyploid with three homoeologous subgenomes (A, B, and D). The ancestors of the subgenomes A and D had been identified, but not for the subgenome B. The goatgrass Aegilops speltoides (genome SS) has been controversi…
View article: A Graph Approach to Mining Biological Patterns in the Binding Interfaces
A Graph Approach to Mining Biological Patterns in the Binding Interfaces Open
Protein-RNA interactions play important roles in the biological systems. Searching for regular patterns in the Protein-RNA binding interfaces is important for understanding how protein and RNA recognize each other and bind to form a comple…
View article: RNA-Seq Revealed Differences in Transcriptomes between 3ADON and 15ADON Populations of Fusarium graminearum In Vitro and In Planta
RNA-Seq Revealed Differences in Transcriptomes between 3ADON and 15ADON Populations of Fusarium graminearum In Vitro and In Planta Open
Fusarium graminearum is the major causal agent of Fusarium head blight (FHB) in barley and wheat in North America. The fungus not only causes yield loss of the crops but also produces harmful trichothecene mycotoxins [Deoxynivalenol (DON) …
View article: Effect of different retailing and home preservation methods on quality of strawberry after forced-air cooling and low temperature transportation.
Effect of different retailing and home preservation methods on quality of strawberry after forced-air cooling and low temperature transportation. Open
Strawberry packaged plastic clamshell containers within carton were used forced-air cooling from 26°C to 3°C, transported at 0°C for 1 day(d), Then the strawberry was either retailed at 4°C with humidification (RH:90%~95%) for 2 days, reta…