Changjong Moon
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View article: Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle
Copper deficiency disrupts OXPHOS and mitochondrial dynamics through MTCH2-dependent copper trafficking in skeletal muscle Open
Copper is an essential trace element required for mitochondrial respiration and cellular metabolism, yet its role in skeletal muscle remains incompletely understood. Here, we show that skeletal muscle-specific deletion of the high-affinity…
View article: Molecular detection and characterization of Anaplasma phagocytophilum and Neoehrlichia mikurensis in wild rodents and their ectoparasites in South Korea
Molecular detection and characterization of Anaplasma phagocytophilum and Neoehrlichia mikurensis in wild rodents and their ectoparasites in South Korea Open
View article: Corrigendum: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods
Corrigendum: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods Open
View article: Retraction: Corrigendum: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods
Retraction: Corrigendum: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods Open
View article: The prevalence and genetic diversity of Bartonella species in wild rodents from South Korea
The prevalence and genetic diversity of Bartonella species in wild rodents from South Korea Open
Bartonella species, which are globally distributed gram-negative facultative intracellular bacteria, can infect a diverse range of hosts. Rodents are crucial for the maintenance and dissemination of Bartonella spp., several of which are pa…
View article: Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer’s Disease Mouse Model
Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer’s Disease Mouse Model Open
Background: Neuroplasticity and synaptic homeostasis are essential in regulating neuronal activity and behavioral functions within the hippocampus. Alzheimer’s disease (AD) is characterized by progressive cognitive decline, pathological ac…
View article: Corrigendum: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods
Corrigendum: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods Open
View article: Carotenoid-Producing <i>Qipengyuania algicola</i> sp. nov. and <i>Qipengyuania rhodophyticola</i> sp. nov., Isolated from Marine Algae, and Emended Description of the Genus <i>Qipengyuania</i> Xu <i>et al</i>. 2020
Carotenoid-Producing <i>Qipengyuania algicola</i> sp. nov. and <i>Qipengyuania rhodophyticola</i> sp. nov., Isolated from Marine Algae, and Emended Description of the Genus <i>Qipengyuania</i> Xu <i>et al</i>. 2020 Open
Two Gram-stain-negative, facultatively aerobic, non-motile, catalase- and oxidase-positive, rod-shaped bacteria, designated strains DGS2-2T (orange-pigmented) and DGS5-3T (yellow-pigmented), were isolated from marine …
View article: Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model
Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model Open
Copper oxide nanoparticles (CuONPs) are increasingly used across various industrial applications, raising concerns about their potential toxicity and necessitating comprehensive safety evaluations. In this study, we first evaluated the res…
View article: Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods
Staphylococcus parequorum sp. nov. and Staphylococcus halotolerans sp. nov., isolated from traditional Korean soybean foods Open
Strains Mo2-6T, S9, KG4-3T, and 50Mo3-2, identified as coagulase-negative, Gram-stain-positive, halotolerant, non-motile coccoid bacteria, were isolated from traditional Korean soybean foods. Strains Mo2-6T and S9 were both catalase- and o…
View article: Elevated osteopontin reflects systemic inflammation in experimental autoimmune encephalomyelitis
Elevated osteopontin reflects systemic inflammation in experimental autoimmune encephalomyelitis Open
We examined the expression and localization of osteopontin (OPN) in various organs in mice with experimental autoimmune encephalomyelitis (EAE). To evaluate the level of OPN in blood and various tissues, enzyme-linked immunosorbent assay a…
View article: Inverse agonist of ERRγ controls influenza A virus and SARS-CoV-2 infections by targeting SREBP-1c-mediated fatty acid biosynthesis
Inverse agonist of ERRγ controls influenza A virus and SARS-CoV-2 infections by targeting SREBP-1c-mediated fatty acid biosynthesis Open
The periodic emergence of pandemic RNA viral infections, such as COVID-19 and pandemic flus, and the declining efficacy of virus-targeting drugs underscore the need for innovative therapies. Here, we identify the nuclear receptor estrogen-…
View article: A potential interference of chemoreception in inflamed vomeronasal organ with experimental autoimmune encephalomyelitis
A potential interference of chemoreception in inflamed vomeronasal organ with experimental autoimmune encephalomyelitis Open
Inflammation of the vomeronasal organ (VNO) was evaluated in the context of experimental autoimmune encephalomyelitis (EAE). The VNO was sampled in mice with myelin oligodendrocyte glycoprotein-induced EAE, and processed for paraffin embed…
View article: Hippocampal Neuroplasticity and Adult Neurogenesis: Mechanisms and Implications
Hippocampal Neuroplasticity and Adult Neurogenesis: Mechanisms and Implications Open
View article: 5-aminolevulinic acid treatment improves sow hematology and the growth rate in piglet
5-aminolevulinic acid treatment improves sow hematology and the growth rate in piglet Open
View article: Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination
Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination Open
Melanoma is a serious type of skin cancer that originates from melanocytes. Rodent melanoma models have provided valuable insights into melanoma pathology; however, they often lack applicability to humans owing to genetic, anatomical, phys…
View article: <i>In Silico</i> Analysis Reveals Overlapping Molecular Mechanisms Between COVID-19 and Attention-Deficit/Hyperactivity Disorder
<i>In Silico</i> Analysis Reveals Overlapping Molecular Mechanisms Between COVID-19 and Attention-Deficit/Hyperactivity Disorder Open
View article: Comparative analysis of ERK and CREB activity in normal and cryptorchid testes of bulls
Comparative analysis of ERK and CREB activity in normal and cryptorchid testes of bulls Open
Our findings demonstrate that cryptorchidism alters testicular morphology and disrupts key signaling pathways, particularly those involved in cell growth and function. Such alterations may contribute to infertility and highlight the import…
View article: Transcriptional Profiling Uncovers Microglial Hif-1α Signaling as a Therapeutic Target of Radiation-Induced Brain Injury
Transcriptional Profiling Uncovers Microglial Hif-1α Signaling as a Therapeutic Target of Radiation-Induced Brain Injury Open
View article: TRPV1-Expressing Neurons in the Dorsal Raphe Nucleus are Activated by Self or Others’ Pain
TRPV1-Expressing Neurons in the Dorsal Raphe Nucleus are Activated by Self or Others’ Pain Open
View article: Anti-Amnesic Effect of Agastache rugosa on Scopolamine-Induced Memory Impairment in Mice
Anti-Amnesic Effect of Agastache rugosa on Scopolamine-Induced Memory Impairment in Mice Open
Agastache rugosa, a traditional Asian herbal medicine, is primarily used for digestive problems; yet, its cognitive benefits remain unexplored. This study evaluated the anti-amnesic effects of A. rugosa extract (ARE) on scopolamine (SCO)-i…
View article: Recent Insights into Hippocampal Dysfunction and Neuroplasticity in Sleep Disorders: An Update from Preclinical Studies
Recent Insights into Hippocampal Dysfunction and Neuroplasticity in Sleep Disorders: An Update from Preclinical Studies Open
Sleep disorders are prevalent neurological conditions linked to neurocognitive impairments. Understanding the neuroplasticity changes in the hippocampus, which plays a central role in regulating neurocognitive function, is crucial in the c…
View article: Pycnogenol-Assisted Alleviation of Titanium Dioxide Nanoparticle-Induced Lung Inflammation via Thioredoxin-Interacting Protein Downregulation
Pycnogenol-Assisted Alleviation of Titanium Dioxide Nanoparticle-Induced Lung Inflammation via Thioredoxin-Interacting Protein Downregulation Open
Titanium dioxide nanoparticles (TiO2NPs) are used in products that are applied to the human body, such as cosmetics and food, but their biocompatibility remains controversial. Pycnogenol (PYC), a natural extract of pine bark, exerts anti-i…
View article: Establishment of porcine embryonic stem cells in simplified serum free media and feeder free expansion
Establishment of porcine embryonic stem cells in simplified serum free media and feeder free expansion Open
View article: Integrated Genome-Wide Analysis of DNA Methylation and Gene Expression in the Hippocampi of 5xFAD Alzheimer’s Disease Mouse Model
Integrated Genome-Wide Analysis of DNA Methylation and Gene Expression in the Hippocampi of 5xFAD Alzheimer’s Disease Mouse Model Open
Background: DNA methylation forms 5-methylcytosine and its regulation in the hippocampus is critical for learning and memory. Indeed, dysregulation of DNA methylation is associated with neurological diseases. Alzheimer’s disease (AD) is th…
View article: Pycnogenol-Assisted Alleviation of Titanium Dioxide Nanoparticle-Induced Lung Inflammation via Thioredoxin-Interacting Protein Downregulation
Pycnogenol-Assisted Alleviation of Titanium Dioxide Nanoparticle-Induced Lung Inflammation via Thioredoxin-Interacting Protein Downregulation Open
Titanium dioxide nanoparticles (TiO2NPs) are used in products that are applied to the human body, such as cosmetics and food, but their biocompatibility remains controversial. Pycnogenol (PYC), a natural extract of pine bark, exerts anti-i…
View article: Antiepileptic and Neuroprotective Effects of Rheum tanguticum Root Extract on Trimethyltin-Induced Epilepsy and Neurodegeneration: In Vivo and in Silico Analyses
Antiepileptic and Neuroprotective Effects of Rheum tanguticum Root Extract on Trimethyltin-Induced Epilepsy and Neurodegeneration: In Vivo and in Silico Analyses Open
Background: Rheum tanguticum root, cataloged as “Daehwang” in the Korean Pharmacopeia, is rich in various anthraquinones known for their anti-inflammatory and antioxidant properties. Formulations containing Daehwang are traditionally emplo…
View article: Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9
Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9 Open
CD46, a transmembrane protein known for protecting cells from complement‑mediated damage, is frequently dysregulated in various types of cancer. Its overexpression in bladder cancers safeguards the cancer cells against both complement and …
View article: Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease
Possible association of G6PC2 and MUC6 induced by low‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease Open
Although there are several types of radiation exposure, it is debated whether low‑dose‑rate (LDR) irradiation (IR) affects the body. Since the small intestine is a radiation‑sensitive organ, the present study aimed to evaluate how it chang…
View article: Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling
Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling Open
Parkinson’s disease (PD) often results in hippocampal dysfunction, which leads to cognitive and emotional challenges and synaptic irregularities. This study attempted to assess behavioral anomalies and identify differentially expressed gen…