Explanipedia

Comprehensive ceRNA Network Analysis Reveals Regulatory Mechanisms of mRNA, miRNA, circRNA, and lncRNA in Methcathinone-Induced Neurotoxicity Open

Ronghua Zhou, Yingwen Xu, Chun Xu, Zhe Chen, Jieping Lv , et al. · 2025

Methcathinone, a synthetic cathinone derivative similar to amphetamine, has raised public health concerns due to its addictive properties and health risks associated with neurotoxicity. Low-dose, medium-dose, and high-dose methcathinone-in…

From bench to bed: deep insights the tacrolimus-induced diabetes and gut microbiota dysbiosis Open

Yuting Han, Zhuan Bian, Jinmin Zhao, Haiying Xiao, Hongyu Wang , et al. · 2025

Ethics in Patient Preferences for Artificial Intelligence–Drafted Responses to Electronic Messages Open

Joanna S Cavalier, Benjamin A. Goldstein, Vardit Ravitsky, Jean‐Christophe Bélisle‐Pipon, Armando Bedoya , et al. · 2025

Importance The rise of patient messages sent to clinicians via a patient portal has directly led to physician burnout and dissatisfaction, prompting uptake of artificial intelligence (AI) to alleviate this burden. It is important to unders…

Comparison of Deep Learning and Traditional Machine Learning Models for Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers Open

Kesheng Wang, Donald Adjeroh, Wei Fang, Suzy Mascaro Walter, Danqing Xiao , et al. · 2025

Mild cognitive impairment (MCI) is a clinical condition characterized by a decline in cognitive ability and progression of cognitive impairment. It is often considered a transitional stage between normal aging and Alzheimer’s disease (AD).…

Key issues in recruitment for minority aging research in humanitarian settings Open

Rosa P. Pirela‐Mavarez, Chun Xu, Joseph D. Terwilliger, Noe Garza, Romina Adriana Clamont Reyes , et al. · 2024

Background The increasing number of natural disasters and wars will result in complex emergencies affecting how individuals age. Additionally, the continued complex crises in certain areas of the globe exacerbates risks for chronic health …

Feature Selection and Machine Learning Approaches in Prediction of Current E-Cigarette Use Among U.S. Adults in 2022 Open

Wei Fang, Ying Liu, Chun Xu, Xingguang Luο, Kesheng Wang · 2024

Feature selection is essentially the process of picking informative and relevant features from a larger collection of features. Few studies have focused on predictors for current e-cigarette use among U.S. adults using feature selection an…

Plasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study Open

Laurie A. Theeke, Ying Liu, Silas Wang, Xingguang Luο, R. Osvaldo Navia , et al. · 2024

The co-occurrence of Alzheimer’s disease (AD) and cardiovascular diseases (CVDs) in older adults highlights the necessity for the exploration of potential shared risk factors. A total of 566 adults were selected from the Alzheimer’s Diseas…

The mechanism of MRSA drug tolerance and the comparison between vancomycin and daptomycin in the treatment of MRSA infections Open

Chun Xu, Yuming Li, Yan Pan, Yanzi Li, Yanning Zhang · 2024

Methicillin-resistant Staphylococcus aureus (MRSA) is a superbug that is resistant to multiple antibiotics commonly used in medication and has caused severe infections in humans for hundreds of years. This review examines the MRSA drug res…

Clinical and genetic characteristics of Chinese pediatric and adult patients with hereditary spherocytosis Open

Chongjun Wu, Yi-Xin Yan, Ting Xiong, Wen Jiang, Jing Xu , et al. · 2024

Objective This study aimed to investigate the clinical features, pathogenic gene variants, and potential genotype–phenotype correlations in Chinese patients with hereditary spherocytosis (HS). Methods Retrospective analysis of clinical dat…

The Association of Post–Lung Transplant Pulmonary Embolism With the Development of Chronic Lung Allograft Dysfunction Open

Justin Magin, Chun Xu, Sarah B. Peskoe, Michael Dorry, Courtney W. Frankel , et al. · 2024

Background. Pulmonary embolism (PE) is a rare yet serious postoperative complication for lung transplant recipients (LTRs). The association between timing and severity of PE and the development of chronic allograft lung dysfunction (CLAD) …

APOE Gene Associated with Dementia-Related Traits, Depression, and Anxiety in the Hispanic Population Open

Chun Xu, Victoria Padilla, Stéphanie Lozano, Daniela Gamez, Bin Su , et al. · 2023

Alzheimer’s disease (AD), a main cause of dementia, is commonly seen in aging populations with a strong genetic component. AD is one of the most common neurodegenerative disorders; it is a genetically and clinically heterogeneous disease. …

Sleep Apnea and Substance Use Disorders Associated with Co-Occurrence of Anxiety Disorder and Depression among U.S. Adults: Findings from the NSDUH 2008–2014 Open

Chun Xu, Priscila Acevedo, Liang Wang, Nianyang Wang, Kaysie Ozuna , et al. · 2023

Few studies have focused on sleep apnea and substance use disorders with co-occurrence of anxiety disorder and depression. This study included a total of 270,227 adults, 9268 with co-occurrence of anxiety disorder and depression in the pas…

Altered DNA methylation of CYP2E1 gene in schizophrenia patients with tardive dyskinesia Open

Ping Zhang, Yanli Li, Kesheng Wang, Junchao Huang, Bin Su , et al. · 2022

Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer’s Disease and Cardiovascular Diseases Open

Chun Xu, D. Muñoz García, Yongke Lu, Kaysie Ozuna, Donald Adjeroh , et al. · 2021

Angiotensin-converting enzyme-1 (ACE1) and apolipoproteins (APOs) may play important roles in the development of Alzheimer’s disease (AD) and cardiovascular diseases (CVDs). This study aimed to examine the associations of AD, CVD, and endo…

APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population Open

Stéphanie Lozano, Victoria Padilla, Manuel Lee Avila, Mario Gil, Gladys E. Maestre , et al. · 2021

Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercho…

Comparison of Cox Regression and Parametric Models for Survival Analysis of Genetic Variants in Hnf1b Gene Related to Age at Onset of Cancer Open

Kesheng Wang, Xuefeng Liu, Yue Pan, Daniel Owusu, Chun Xu · 2021

Semi-parametric Cox regression and parametric methods have been used to analyze survival data of cancer; however, no study has focused on the comparison of survival models in genetic association analysis of age at onset (AAO) of cancer. Th…

Racial Differences in the Effect of APOE-ε4 Genotypes on Trail Making Test Part B in Alzheimer’s disease Open

Chun Xu, Priscila Acevedo, Yongke Lu, Bin Su, Victoria Padilla , et al. · 2021

The trail making test part B (TMT-B) evaluates "executive" functions, memory, and sensorimotor functions. No previous studies were found to examine the longitudinal effect of apolipoprotein E epsilon 4 (APOE-ε4) genotypes on the TMT-B scor…

Abnormal Anhedonia as a Potential Endophenotype in Obsessive–Compulsive Disorder Open

Chun Xu, J Chen, Zilin Cui, Heyou Han, G. Wan , et al. · 2020

Chuanyong Xu,1,* Jierong Chen,2,* Zitian Cui,1 Rongzhen Wen,1 Hongying Han,3 Lili Jin,1 Guobin Wan,2 Zhen Wei,2 Ziwen Peng1 1Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, P…

Gender differences in the associations of early onset poly tobacco and drug use prior to age 18 with the prevalence of adult bronchitis in the United States Open

Muyiwa Ategbole, Bin Su, Nianyang Wang, Elaine Loudermilk, Xin Xie , et al. · 2020

Obesity, early onset poly tobacco use prior to age 18, and tobacco use in the past year were positively associated with bronchitis; furthermore, the associations of early onset polysubstance use with bronchitis differed by gender, which in…

Enlightenments of asymptomatic cases of SARS-CoV-2 infection Open

Jingbo Wang, Lei-Shi Wang, Luping Li, Jiao Xu, Chun Xu , et al. · 2020

This article reports two asymptomatic cases of SARS-CoV-2 infection. Both cases came from Hubei Province. One was a 63-year-old male and the other was a 29-year-old female. Both were diagnosed with SARS-CoV-2 infection during the screening…

Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer’s Disease Open

Shaoqing Gong, Bin Su, Hugo Tovar, Chunxiang Mao, Valeria González , et al. · 2018

RYR3 variants are associated with hypertension, diabetes, and AD. Replication of these results of this gene in these 3 complex traits may help to better understand the genetic basis of calcium-signaling gene, RYR3 in association with risk …

Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults Open

Kesheng Wang, Ying Liu, Youssoufou Ouédraogo, Nianyang Wang, Xin Xie , et al. · 2018

Bayesian Cox Proportional Hazards Model in Survival Analysis of HACE1 Gene with Age at Onset of Alzheimer's Disease Open

Kesheng Wang, Ying Liu, Gong Shaoqing, Chun Xu, Xin Xie , et al. · 2017

Alzheimer's disease (AD), the most common form of dementia, is a chronic neurodegenerative disease. The HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) gene is expressed in human brain and may play a role in…

Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol Open

Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luο, Kesheng Wang · 2017

Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease Open

Ke-Sheng Wang, Ying Liu, Chun Xu, Xuefeng Liu, Xingguang Luο · 2017

Genetic association analysis of polymorphisms in PSD3 gene with obesity, type 2 diabetes, and HDL cholesterol Open

Shaoqing Gong, Chun Xu, Liang Wang, Ying Liu, Daniel Owusu , et al. · 2017

The Impact of Drug and Gene Interaction on the Antipsychotic Medication for Schizophrenia Open

Michelle Cho, Adriana Contreras, Ashley Garza, Samantha Olvera, David Castillo‐Azofeifa , et al. · 2017

Objective: Schizophrenia, a neuropsychiatric disorder, is known to be neurodevelopmentally progressive. Due to the extensive interindividual variability found in the responses of patients, management of schizophrenia has proven to be chall…

Principal Component Regression Analysis of Nutrition Factors and Physical Activities with Diabetes Open

Ke Sheng Wang, Ying Liu, Xin Xie, Shaoqing Gong, Chun Xu , et al. · 2017

The associations of nutrition factors and physical activities with adult diabetes are inconsistent; while most of these factors are inter correlated. The aims of this study are to overcome the disturbance of the multicollinearity of the ri…

Systematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis Open

Jing Hu, Jinyuan Xu, Lin Pang, Hongying Zhao, Feng Li , et al. · 2016

Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed "major psychosis". Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important rol…

Novel Somatic Copy Number Alteration Identified for Cervical Cancer in the Mexican American Population Open

Alireza Torabi, Javier Ordoñez, Bin Su, Laura Palmer, Chunxiang Mao , et al. · 2016

Cervical cancer affects millions of Americans, but the rate for cervical cancer in the Mexican American is approximately twice that for non-Mexican Americans. The etiologies of cervical cancer are still not fully understood. A number of so…

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