Changlin Tian
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View article: Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization
Structural insights into the progressive recovery of α7 nicotinic acetylcholine receptor from nicotine-induced desensitization Open
Nicotine is the predominant alkaloid in tobacco leaves and affects the human nervous system by interacting with nicotinic acetylcholine receptors (nAChRs). Chronic nicotine exposure leads to nAChR desensitization, while nicotine withdrawal…
View article: Spin-polarized chiral ZnIn2S4 for targeted solar-driven CO2 reduction to acetic acid
Spin-polarized chiral ZnIn2S4 for targeted solar-driven CO2 reduction to acetic acid Open
Acetic acid, an important industrial chemical, is a key target product for CO2 reduction due to its dual role in carbon utilization and chemical feedstock supply. Although photocatalytic CO2 reduction (PCCR) can generate acetic acid alongs…
View article: A Molecular Mechanism for the Reduction of the Cu Site in Lytic Polysaccharide Monooxygenases by Phenol Reductants
A Molecular Mechanism for the Reduction of the Cu Site in Lytic Polysaccharide Monooxygenases by Phenol Reductants Open
Lytic polysaccharide monooxygenases (LPMOs) play a pivotal role in the degradation of recalcitrant polysaccharides. As abundant reductants in nature, phenolic compounds may serve as sustainable reducing agents for LPMO reactions. However, …
View article: Assisting and accelerating NMR assignment with restrained structure prediction
Assisting and accelerating NMR assignment with restrained structure prediction Open
Accurate dynamic protein structures are essential for drug design. NMR experiments can detect protein structures and potential dynamics, but the spectrum assignment and structure determination requires expertise and is time-consuming, whil…
View article: Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors
Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors Open
The α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation. As a potential drug target, α7 nAChR has different binding sites for differ…
View article: Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action
Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action Open
Our skin safeguards the body homeostasis for health and also provides psychological consolation in social life. Natural essential oils are widely used for skin maintenance, while the molecular target and mechanism of action remain largely …
View article: Blockchain Consensus Scheme Based on the Proof of Distributed Deep Learning Work
Blockchain Consensus Scheme Based on the Proof of Distributed Deep Learning Work Open
With the development of artificial intelligence and blockchain technology, the training of deep learning models needs large computing resources. Meanwhile, the Proof of Work (PoW) consensus mechanism in blockchain systems often leads to th…
View article: Analysis of the electron transfer pathway in small laccase by EPR and UV–vis spectroscopy coupled with redox titration
Analysis of the electron transfer pathway in small laccase by EPR and UV–vis spectroscopy coupled with redox titration Open
Bacterial small laccases (SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline pH. Electron transfer between substrate, copper c…
View article: Cryo-EM structure of HQNO-bound alternative complex III from the anoxygenic phototrophic bacterium <i>Chloroflexus aurantiacus</i>
Cryo-EM structure of HQNO-bound alternative complex III from the anoxygenic phototrophic bacterium <i>Chloroflexus aurantiacus</i> Open
Alternative complex III (ACIII) couples quinol oxidation and electron acceptor reduction with potential transmembrane proton translocation. It is compositionally and structurally different from the cytochrome bc1/b6f complexes but function…
View article: Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168
Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168 Open
s The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3 ligase, plays a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of the adjacent Lys13 and Lys15 sites at the H2A N-ter…
View article: In vivo labeling and quantitative imaging of neuronal populations using MRI
In vivo labeling and quantitative imaging of neuronal populations using MRI Open
The study of neural circuits, which underlies perception, cognition, emotion, and behavior, is essential for understanding the mammalian brain, a complex organ consisting of billions of neurons. To study the structure and function of the b…
View article: Fluoride permeation mechanism of the Fluc channel in liposomes revealed by solid-state NMR
Fluoride permeation mechanism of the Fluc channel in liposomes revealed by solid-state NMR Open
Solid-state nuclear magnetic resonance (ssNMR) methods can probe the motions of membrane proteins in liposomes at the atomic level and propel the understanding of biomolecular processes for which static structures cannot provide a satisfac…
View article: Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists Open
Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist neurokinin B (NKB) preferentially activates NK3R, while substance P (SP) binds preferentially to NK…
View article: Overview and progress of X-nuclei magnetic resonance imaging in biomedical studies
Overview and progress of X-nuclei magnetic resonance imaging in biomedical studies Open
Proton nuclear (1H) is the observed nucleus on which most magnetic resonance imaging (MRI) applications depend. Most traditional 1H MRI can provide structural and functional information about organisms, while various non-proton nuclei (X-n…
View article: Structure of the human respiratory complex II
Structure of the human respiratory complex II Open
Human complex II is a key protein complex that links two essential energy-producing processes: the tricarboxylic acid cycle and oxidative phosphorylation. Deficiencies due to mutagenesis have been shown to cause mitochondrial disease and s…
View article: New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats
New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats Open
The HME preparation significantly increased the oral bioavailability and anti-cholestatic effect of pure IMB16-4, but caused liver injury at high dose, which require a dose balance between the curative effect and safety in the future resea…
View article: Direct Visible-Light-Excited Flavoproteins for Redox-Neutral Asymmetric Radical Hydroarylation
Direct Visible-Light-Excited Flavoproteins for Redox-Neutral Asymmetric Radical Hydroarylation Open
the atomic coordinates of the optimized computational models
View article: Identification and characterization of a novel hydroxylamine oxidase, DnfA, that catalyzes the oxidation of hydroxylamine to N2
Identification and characterization of a novel hydroxylamine oxidase, DnfA, that catalyzes the oxidation of hydroxylamine to N2 Open
Nitrogen (N2) gas in the atmosphere is partially replenished by microbial denitrification of ammonia. Recent study has shown that Alcaligenes ammonioxydans oxidizes ammonia to dinitrogen via a process featuring the intermediate hydroxylami…
View article: Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues
Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues Open
The endogenous cyclic tetradecapeptide SST14 was reported to stimulate all five somatostatin receptors (SSTR1–5) for hormone release, neurotransmission, cell growth arrest and cancer suppression. Two SST14-derived short cyclic SST analogue…
View article: Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug Open
Significance Voltage-gated potassium channels (Kv) open with membrane depolarization and allow the flow of K + ions. Ion flow is tightly governed by time-dependent entry into nonconducting inactivated states. Here, we focus on Kv1.3, a cha…