Changlong Guo
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View article: Hunyuan3D Studio: End-to-End AI Pipeline for Game-Ready 3D Asset Generation
Hunyuan3D Studio: End-to-End AI Pipeline for Game-Ready 3D Asset Generation Open
The creation of high-quality 3D assets, a cornerstone of modern game development, has long been characterized by labor-intensive and specialized workflows. This paper presents Hunyuan3D Studio, an end-to-end AI-powered content creation pla…
View article: Auto-Connect: Connectivity-Preserving RigFormer with Direct Preference Optimization
Auto-Connect: Connectivity-Preserving RigFormer with Direct Preference Optimization Open
We introduce Auto-Connect, a novel approach for automatic rigging that explicitly preserves skeletal connectivity through a connectivity-preserving tokenization scheme. Unlike previous methods that predict bone positions represented as two…
View article: AB0146 A SINGLE-CELL AND SPATIALLY RESOLVED ATLAS OF LUPUS NEPHRITIS
AB0146 A SINGLE-CELL AND SPATIALLY RESOLVED ATLAS OF LUPUS NEPHRITIS Open
Background Systemic lupus erythematosus is a typical autoimmune disease with multiple clinical complications. Lupus nephritis (LN) affects half of the patients and is the leading cause of both death and morbidity[1]. Although previous stud…
View article: A184 REPURPOSING DRUGS FOR SPLEEN TYROSINE KINASE (SYK) PEDIATRIC PATIENTS USING HIGH-THROUGHPUT SCREENING
A184 REPURPOSING DRUGS FOR SPLEEN TYROSINE KINASE (SYK) PEDIATRIC PATIENTS USING HIGH-THROUGHPUT SCREENING Open
Background Spleen Tyrosine Kinase (SYK) is a cytosolic, non-receptor tyrosine kinase with an imperative role in immune and non-immune processes. Recently, we identified six gain-of-function SYK variants in patients that presented multi-org…
View article: Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome
Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome Open
SAPHO syndrome is a rare chronic inflammatory disease which is characterized by the comprehensive manifestations of bone, joint, and skin. However, little is known about the pathogenesis of SAPHO syndrome. A genome-wide association study (…
View article: A167 UNDERSTANDING THE IMPACT OF DOWNSTREAM OF KINASE 4 (DOK4) DAMAGING GENETIC VARIANTS IN THE PATHOGENESIS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE (IBD).
A167 UNDERSTANDING THE IMPACT OF DOWNSTREAM OF KINASE 4 (DOK4) DAMAGING GENETIC VARIANTS IN THE PATHOGENESIS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE (IBD). Open
Background IBD is a chronic inflammatory disorder of the gastrointestinal (GI) tract whose precise pathological mechanisms remain elusive. It is thought that in pediatric IBD, pathogenic exposure does not appear sufficient to cause disease…
View article: Red Blood Cells in The First Trimester and The Risk of Gestational Diabetes: A Prospective Cohort Study
Red Blood Cells in The First Trimester and The Risk of Gestational Diabetes: A Prospective Cohort Study Open
Background: This research aimed to assess the potential association of gestational diabetes (GDM) with early trimester hematological parameters including hemoglobin (Hb), red blood cell (RBC), white blood cell (WBC), and platelet count (PL…
View article: Profiling the pattern of human TRB/IGH‐CDR3 repertoire in liver transplantation patients via high‐throughput sequencing analysis
Profiling the pattern of human TRB/IGH‐CDR3 repertoire in liver transplantation patients via high‐throughput sequencing analysis Open
Immune processes in liver transplantation remain poorly understood. Acute allograft rejection in liver transplantation is a kind of T cell–mediated inflammatory disease accompanied by inflammatory cell infiltration. However, the effect of …
A33 THE ROLE OF A HOMOZYGOUS PROTEIN CODING VARIANT OF EPS8 IN THE PATHOGENESIS OF PEDIATRIC IBD Open
Background The rate of onset for Inflammatory Bowel Disease (IBD) is rising worldwide—most significantly in the pediatric population. The pathogenesis of the disease involves a complicated interaction between the environment and genetics. …
A252 FUNCTIONAL ANALYSIS OF GENETIC AETIOLOGIES IN A DOWNSTREAM OF TYROSINE KINASE (DOK) PROTEIN IN THE PATHOGENESIS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE (IBD) Open
Background IBD is a form of chronic inflammatory disorder of the gastrointestinal tract that arises due to genetic, environmental, immunological and microbial factors. The precise pathological mechanisms remain elusive. It is thought that …
A39 NOVEL GAIN OF FUNCTION NON-RECEPTOR TYROSINE KINASE MUTATIONS ARE LINKED TO THE PATHOGENESIS OF VEOIBD Open
Background Very early-onset inflammatory bowel disease (VEOIBD) is an emerging global disease, that results in inflammation of the digestive tract. Severe forms of VEOIBD can be caused by mutations in a single gene (monogenic variants) and…
View article: Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery
Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Open
Background Delirium is common in elderly patients after surgery and is associated with poor outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on the incidence of delirium in elderly patients undergoing …
View article: Copy Number Variation of Multiple Genes in SAPHO Syndrome
Copy Number Variation of Multiple Genes in SAPHO Syndrome Open
Objective. SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a type of rare chronic aseptic inflammation of unknown etiology. To date, no research to our knowledge has reported copy number variation (CNV) of genes tha…
View article: A276 INVESTIGATING THE ROLE OF TTC7A THROUGH ITS INTERACTION WITH UBR5 TO MAINTAIN CELL SURVIVAL
A276 INVESTIGATING THE ROLE OF TTC7A THROUGH ITS INTERACTION WITH UBR5 TO MAINTAIN CELL SURVIVAL Open
BACKGROUND: Patients with mutations in Tetratricopeptide Repeat Domain 7A (TTC7A) results in a severe and untreatable form of inflammatory bowel disease with the majority dying before 2 years of age. Pathological features of these patients…
View article: A89 FUNCTIONAL ANALYSIS OF NEUTROPHIL CYTOSOLIC FACTOR 4 (NCF4) IN THE PATHOGENESIS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE
A89 FUNCTIONAL ANALYSIS OF NEUTROPHIL CYTOSOLIC FACTOR 4 (NCF4) IN THE PATHOGENESIS OF PEDIATRIC INFLAMMATORY BOWEL DISEASE Open
BACKGROUND: Inflammatory bowel disease (IBD) can arise because of various genetic, environmental, immunological and microbial factors, however, the precise pathological mechanisms leading to IBD remains elusive. Recent advances in genomics…
View article: A81 FUNCTIONAL ANALYSIS IMPLICATING SAMD9 MUTATION FOR INTESTINAL INFLAMMATION IN PATIENTS WITH MIRAGE SYNDROME AND INFLAMMATORY BOWEL DISEASE
A81 FUNCTIONAL ANALYSIS IMPLICATING SAMD9 MUTATION FOR INTESTINAL INFLAMMATION IN PATIENTS WITH MIRAGE SYNDROME AND INFLAMMATORY BOWEL DISEASE Open
BACKGROUND: MIRAGE syndrome is caused by heterozygous mutation in the SAMD9 gene. The syndrome is characteristic of enteropathy, and is often fatal within the first 2 years of life. However, the pathogenesis of enteropathy in the syndrome …
View article: A91 NOVEL TRIM22 INTERACTIONS REVEAL POTENTIAL CAUSATIVE MECHANISMS IN VERY EARLY ONSET INFLAMMATORY BOWEL DISEASE (VEOIBD)
A91 NOVEL TRIM22 INTERACTIONS REVEAL POTENTIAL CAUSATIVE MECHANISMS IN VERY EARLY ONSET INFLAMMATORY BOWEL DISEASE (VEOIBD) Open
BACKGROUND: The severe multi-systemic phenotype of VEOIBD is often difficult to treat with conventional therapies. Causative monogenic mutations have been identified, but the majority of VEOIBD patients present without any known defect. Ou…
View article: Exome sequencing reveals novel IRXI mutation in congenital heart disease
Exome sequencing reveals novel IRXI mutation in congenital heart disease Open
Genetic variation in specific transcription factors during heart formation may lead to congenital heart disease (CHD) or even miscarriage. The aim of the present study was to identify CHD‑associated genes using next generation sequencing (…